Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLHL15
  • Mouse genes Klhl15
  • Rat genes Klhl15
  • Zfish genes klhl15
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klhl15

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	KLHL15	IPI	UniProtKB:Q99708	Human	PMID:27561354
Molecular Function	GO:0005515	protein binding	KLHL15	IPI	UniProtKB:O15075	Human	PMID:33199366
Molecular Function	GO:0005515	protein binding	KLHL15	IPI	UniProtKB:O88809	Human	PMID:33199366
Molecular Function	GO:0005515	protein binding	KLHL15	IPI	UniProtKB:Q8N568	Human	PMID:33199366
Molecular Function	GO:0005515	protein binding	KLHL15	IPI	UniProtKB:P0DW81	Human	PMID:35219381
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHL15	IDA		Human	PMID:27561354
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHL15	IDA		Human	PMID:35219381
Cellular Component	GO:0005634	nucleus	KLHL15	IDA		Human	PMID:27561354
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	KLHL15	IDA		Human	PMID:27561354
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	KLHL15	IDA		Human	PMID:35219381
Biological Process	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	KLHL15	IDA		Human	PMID:27561354
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	KLHL15	IDA		Human	PMID:27561354

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern