Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLHL22
  • Mouse genes Klhl22
  • Rat genes Klhl22
  • Zfish genes klhl22
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klhl22

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	KLHL22	IPI	UniProtKB:P62258	Human	PMID:29769719
Molecular Function	GO:0005515	protein binding	KLHL22	IPI	UniProtKB:P53350	Human	PMID:23455478
Molecular Function	GO:0005515	protein binding	KLHL22	IPI	UniProtKB:Q8IVD9	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	KLHL22	IPI	UniProtKB:Q8IVD9	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	KLHL22	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	KLHL22	IDA		Human	PMID:36394357
Cellular Component	GO:0005813	centrosome	KLHL22	IDA		Human	PMID:23455478
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	KLHL22	IDA		Human	PMID:19995937
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	KLHL22	IDA		Human	PMID:23455478
Cellular Component	GO:0005737	cytoplasm	KLHL22	IDA		Human	PMID:23455478
Cellular Component	GO:0005829	cytosol	KLHL22	IDA		Human	PMID:29769719
Cellular Component	GO:0045171	intercellular bridge	KLHL22	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	KLHL22	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	KLHL22	IDA		Human	PMID:29769719
Cellular Component	GO:0015630	microtubule cytoskeleton	KLHL22	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	KLHL22	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	KLHL22	IDA		Human	PMID:23455478
Cellular Component	GO:0005634	nucleus	KLHL22	IDA		Human	PMID:29769719
Cellular Component	GO:0005827	polar microtubule	KLHL22	IDA		Human	PMID:23455478
Biological Process	GO:0051301	cell division	KLHL22	IMP		Human	PMID:19995937
Biological Process	GO:0071230	cellular response to amino acid stimulus	Klhl22	IMP		Mouse	MGI:MGI:6162296|PMID:29769719
Biological Process	GO:0071233	cellular response to leucine	KLHL22	IMP		Human	PMID:29769719
Biological Process	GO:0000070	mitotic sister chromatid segregation	KLHL22	IMP		Human	PMID:23455478
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling	KLHL22	IMP		Human	PMID:23455478
Biological Process	GO:0010507	negative regulation of autophagy	KLHL22	IMP		Human	PMID:29769719
Biological Process	GO:0032480	negative regulation of type I interferon production	KLHL22	IDA		Human	PMID:36394357
Biological Process	GO:0030307	positive regulation of cell growth	KLHL22	IMP		Human	PMID:29769719
Biological Process	GO:1904263	positive regulation of TORC1 signaling	KLHL22	IMP		Human	PMID:29769719
Biological Process	GO:1904263	positive regulation of TORC1 signaling	Klhl22	IMP		Mouse	MGI:MGI:6162296|PMID:29769719
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	KLHL22	IMP		Human	PMID:29769719
Biological Process	GO:0006513	protein monoubiquitination	KLHL22	IDA		Human	PMID:23455478
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	KLHL22	IDA		Human	PMID:36394357

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern