Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLK1,KLK2,KLK3
  • Mouse genes Klk1b9
  • Rat genes Klk1,Klk10,Klk1b3,Klk1c10,Klk1c12,Klk1c2,Klk1c3,Klk1c6,Klk1c8,Klk1c9,Klk7
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klk1b9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	KLK3	IDA		Human	PMID:18714013
Molecular Function	GO:0004175	endopeptidase activity	Klk1	IDA		Rat	PMID:16231010|RGD:1641801
Molecular Function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	KLK3	IMP		Human	PMID:8665956
Molecular Function	GO:0008233	peptidase activity	Klk1b9	IDA		Mouse	PMID:1918045
Molecular Function	GO:0005515	protein binding	KLK3	IPI	UniProtKB:P05154	Human	PMID:1725227
Molecular Function	GO:0005515	protein binding	KLK3	IPI	UniProtKB:P05154	Human	PMID:8665956
Molecular Function	GO:0005515	protein binding	KLK3	IPI	UniProtKB:P05154,UniProtKB:Q02383	Human	PMID:8665956
Molecular Function	GO:0005515	protein binding	KLK3	IPI	UniProtKB:Q02383	Human	PMID:8665956
Molecular Function	GO:0004252	serine-type endopeptidase activity	KLK3	IMP		Human	PMID:15563730
Molecular Function	GO:0004252	serine-type endopeptidase activity	KLK2	IDA		Human	PMID:9042371
Molecular Function	GO:0008236	serine-type peptidase activity	Klk1c2	IDA		Rat	PMID:2550051|RGD:634502
Cellular Component	GO:0001669	acrosomal vesicle	Klk1	IDA		Rat	PMID:12558526|RGD:1641807
Cellular Component	GO:0045177	apical part of cell	Klk1	IDA		Rat	PMID:12558526|RGD:1641807
Cellular Component	GO:0070062	extracellular exosome	KLK1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	KLK3	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	KLK2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	KLK3	IDA		Human	PMID:8665956
Cellular Component	GO:0005634	nucleus	KLK1	IDA		Human	PMID:19232384
Cellular Component	GO:0005634	nucleus	KLK3	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Klk1	IDA		Rat	PMID:10773196|RGD:1641811
Cellular Component	GO:0032991	protein-containing complex	KLK3	IDA		Human	PMID:8665956
Biological Process	GO:0002675	positive regulation of acute inflammatory response	Klk1	IMP		Rat	PMID:17015177|RGD:1641800
Biological Process	GO:0002803	positive regulation of antibacterial peptide production	KLK3	IDA		Human	PMID:18714013
Biological Process	GO:0043065	positive regulation of apoptotic process	Klk1	IMP		Rat	PMID:17015177|RGD:1641800
Biological Process	GO:0008284	positive regulation of cell population proliferation	Klk1	IMP		Rat	PMID:17473535|RGD:1641796
Biological Process	GO:0045907	positive regulation of vasoconstriction	Klk1c9	IDA		Rat	PMID:1900513|RGD:1302426
Biological Process	GO:0006508	proteolysis	KLK3	IMP		Human	PMID:15563730
Biological Process	GO:0007584	response to nutrient	Klk1	IEP		Rat	PMID:12489811|RGD:1641808
Biological Process	GO:0031638	zymogen activation	Klk1b9	IDA		Mouse	PMID:1918045

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern