Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLK8
  • Mouse genes Klk8
  • Rat genes Klk8
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klk8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008233	peptidase activity	Klk8	IDA		Mouse	PMID:28267150
Molecular Function	GO:0008233	peptidase activity	Klk8	IMP	MGI:MGI:2678312	Mouse	PMID:28267150
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:P35237	Human	PMID:17761692
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:Q5DT21	Human	PMID:19194479
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:Q8IUH5	Human	PMID:24705354
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:P50454	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLK8	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0004252	serine-type endopeptidase activity	KLK8	IDA		Human	PMID:16337200
Molecular Function	GO:0004252	serine-type endopeptidase activity	Klk8	IDA		Mouse	MGI:MGI:3770569|PMID:12944500
Molecular Function	GO:0004252	serine-type endopeptidase activity	Klk8	IDA		Mouse	MGI:MGI:3770577|PMID:9556608
Cellular Component	GO:0005737	cytoplasm	KLK8	IDA		Human	PMID:17761692
Cellular Component	GO:0005737	cytoplasm	Klk8	IDA		Mouse	MGI:MGI:4835404|PMID:17761692
Cellular Component	GO:0005615	extracellular space	Klk8	IDA		Mouse	MGI:MGI:3770577|PMID:9556608
Cellular Component	GO:0097180	serine protease inhibitor complex	KLK8	IDA		Human	PMID:17761692
Biological Process	GO:0008219	cell death	Klk8	IMP		Mouse	MGI:MGI:3766680|PMID:17629414
Biological Process	GO:0043616	keratinocyte proliferation	Klk8	IMP		Mouse	MGI:MGI:3708194|PMID:17182622
Biological Process	GO:0007613	memory	Klk8	IMP		Mouse	MGI:MGI:3770567|PMID:16308352
Biological Process	GO:0048681	negative regulation of axon regeneration	Klk8	IMP		Mouse	MGI:MGI:3766680|PMID:17629414
Biological Process	GO:0031642	negative regulation of myelination	Klk8	IMP		Mouse	MGI:MGI:3766680|PMID:17629414
Biological Process	GO:0048812	neuron projection morphogenesis	Klk8	IDA		Mouse	MGI:MGI:3770572|PMID:11880192
Biological Process	GO:0050807	regulation of synapse organization	Klk8	IMP		Mouse	MGI:MGI:1933027|PMID:11273653
Biological Process	GO:0009611	response to wounding	Klk8	IDA		Mouse	MGI:MGI:3770594|PMID:11274744
Biological Process	GO:0009611	response to wounding	Klk8	IDA		Mouse	MGI:MGI:3770574|PMID:10421059
Biological Process	GO:0009611	response to wounding	Klk8	IDA		Mouse	MGI:MGI:3770575|PMID:10196465
Biological Process	GO:0050808	synapse organization	Klk8	IMP	MGI:MGI:2678312	Mouse	PMID:16537644

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern