Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KMT2A
  • Mouse genes Kmt2a
  • Rat genes Kmt2a
  • Zfish genes kmt2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kmt2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Kmt2a	IDA		Mouse	PMID:15640349
Molecular Function	GO:0003677	DNA binding	Kmt2a	IDA		Mouse	PMID:24824656
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Kmt2a	IPI	RGD:621250	Rat	RGD:1598407
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	KMT2A	IMP		Human	PMID:15960975
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	KMT2A	IDA		Human	PMID:19187761
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	KMT2A	IDA		Human	PMID:19556245
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	KMT2A	EXP		Human	PMID:22012064
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	KMT2A	IDA		Human	PMID:24235145
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Kmt2a	IMP		Mouse	MGI:MGI:5607228|PMID:21113167
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Kmt2a	IDA		Mouse	MGI:MGI:2446369|PMID:12453418
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Kmt2a	IMP	MGI:MGI:3839794	Mouse	PMID:25834037
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Kmt2a	IMP		Mouse	PMID:16618927
Molecular Function	GO:0042802	identical protein binding	KMT2A	IPI	UniProtKB:Q03164	Human	PMID:10656681
Molecular Function	GO:0042802	identical protein binding	KMT2A	IPI	UniProtKB:Q03164	Human	PMID:11313484
Molecular Function	GO:0070577	lysine-acetylated histone binding	KMT2A	IDA		Human	PMID:19187761
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q9UNP9	Human	PMID:11313484
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O00255	Human	PMID:14992727
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O00255	Human	PMID:15199122
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q15291	Human	PMID:15199122
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:15960975
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q15291	Human	PMID:15960975
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q9H7Z6	Human	PMID:15960975
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:18840606
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q15291	Human	PMID:19187761
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q9UBL3	Human	PMID:19187761
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:19556245
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q15291	Human	PMID:19556245
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P68431	Human	PMID:20541251
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q9UNP9	Human	PMID:20541251
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q6P1J9	Human	PMID:20541477
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q6PD62	Human	PMID:20541477
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q8N7H5	Human	PMID:20541477
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:20818375
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q13309-1	Human	PMID:20818375
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P45481	Human	PMID:20969867
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O08785	Human	PMID:21113167
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q9WTL8	Human	PMID:21113167
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:21220120
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q15291	Human	PMID:21220120
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O00255-2	Human	PMID:22327296
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:22665483
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P10275	Human	PMID:22722839
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O00255	Human	PMID:22936661
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:23870121
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q15291	Human	PMID:23870121
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O75475	Human	PMID:25082813
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O00255	Human	PMID:25305204
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O75475	Human	PMID:25305204
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q96EB6	Human	PMID:25751424
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q15291	Human	PMID:26886794
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:Q9UBL3-3	Human	PMID:26886794
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P61964	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:O75475	Human	PMID:29997176
Molecular Function	GO:0005515	protein binding	KMT2A	IPI	UniProtKB:P10275	Human	PMID:33640491
Molecular Function	GO:0005515	protein binding	Kmt2a	IPI	UniProtKB:O08785|UniProtKB:Q9WTL8	Mouse	MGI:MGI:5607228|PMID:21113167
Molecular Function	GO:0005515	protein binding	Kmt2a	IPI	PR:O88559	Mouse	PMID:16618927
Molecular Function	GO:0042803	protein homodimerization activity	KMT2A	IDA		Human	PMID:11313484
Molecular Function	GO:0106363	protein-cysteine methyltransferase activity	KMT2A	IDA		Human	PMID:24235145
Molecular Function	GO:0045322	unmethylated CpG binding	KMT2A	IDA		Human	PMID:16990798
Molecular Function	GO:0045322	unmethylated CpG binding	KMT2A	IDA		Human	PMID:20010842
Molecular Function	GO:0045322	unmethylated CpG binding	KMT2A	IDA		Human	PMID:29276034
Molecular Function	GO:0008270	zinc ion binding	KMT2A	IDA		Human	PMID:16990798
Molecular Function	GO:0008270	zinc ion binding	KMT2A	IDA		Human	PMID:19187761
Molecular Function	GO:0008270	zinc ion binding	KMT2A	IDA		Human	PMID:29276034
Cellular Component	GO:0005829	cytosol	KMT2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0035097	histone methyltransferase complex	KMT2A	IDA		Human	PMID:19556245
Cellular Component	GO:0071339	MLL1 complex	KMT2A	IPI		Human	PMID:23508102
Cellular Component	GO:0071339	MLL1 complex	KMT2A	IDA		Human	PMID:15960975
Cellular Component	GO:0005654	nucleoplasm	KMT2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	KMT2A	IDA		Human	PMID:11313484
Cellular Component	GO:0005634	nucleus	KMT2A	IDA		Human	PMID:15640349
Cellular Component	GO:0005634	nucleus	KMT2A	IDA		Human	PMID:25593309
Cellular Component	GO:0005634	nucleus	KMT2A	IDA		Human	PMID:22046413
Cellular Component	GO:0005634	nucleus	Kmt2a	IDA		Mouse	PMID:16618927
Cellular Component	GO:0005634	nucleus	Kmt2a	IDA		Mouse	PMID:11555636
Biological Process	GO:0009952	anterior/posterior pattern specification	Kmt2a	IGI	MGI:MGI:1932339	Mouse	PMID:15741318
Biological Process	GO:0009952	anterior/posterior pattern specification	Kmt2a	IMP		Mouse	PMID:16618927
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Kmt2a	IMP		Rat	PMID:31570196|RGD:155888490
Biological Process	GO:0032922	circadian regulation of gene expression	Kmt2a	IMP		Mouse	MGI:MGI:5607228|PMID:21113167
Biological Process	GO:0050890	cognition	Kmt2a	IMP	MGI:MGI:3839794	Mouse	PMID:25834037
Biological Process	GO:0060216	definitive hemopoiesis	Kmt2a	IMP		Mouse	MGI:MGI:5619484|PMID:15556871
Biological Process	GO:0006306	DNA methylation	Kmt2a	IMP		Mouse	PMID:16618927
Biological Process	GO:0035162	embryonic hemopoiesis	Kmt2a	IMP	MGI:MGI:2177818	Mouse	PMID:9639506
Biological Process	GO:0035640	exploration behavior	Kmt2a	IMP	MGI:MGI:3839794	Mouse	PMID:25834037
Biological Process	GO:0048144	fibroblast proliferation	Kmt2a	IMP		Mouse	PMID:15640349
Biological Process	GO:0021782	glial cell development	kmt2a	IMP	ZFIN:ZDB-MRPHLNO-150624-3	Zfish	PMID:25284327
Biological Process	GO:0030097	hemopoiesis	kmt2a	IMP	ZFIN:ZDB-MRPHLNO-111005-2	Zfish	PMID:21784840
Biological Process	GO:0080182	histone H3-K4 trimethylation	KMT2A	IDA		Human	PMID:20861184
Biological Process	GO:0080182	histone H3-K4 trimethylation	Kmt2a	IMP		Rat	PMID:34694864|RGD:155888565
Biological Process	GO:0016570	histone modification	KMT2A	IMP		Human	PMID:15960975
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Kmt2a	IGI	MGI:MGI:95559	Mouse	PMID:22674806
Biological Process	GO:0051899	membrane depolarization	Kmt2a	IEP		Rat	PMID:20211609|RGD:9588219
Biological Process	GO:1905642	negative regulation of DNA methylation	KMT2A	IMP		Human	PMID:20010842
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Kmt2a	IMP		Mouse	PMID:15640349
Biological Process	GO:0022008	neurogenesis	kmt2a	IMP	ZFIN:ZDB-MRPHLNO-150624-3	Zfish	PMID:25284327
Biological Process	GO:0048823	nucleate erythrocyte development	kmt2a	IMP	ZFIN:ZDB-MRPHLNO-111005-2	Zfish	PMID:21784840
Biological Process	GO:0048823	nucleate erythrocyte development	kmt2a	IMP	ZFIN:ZDB-MRPHLNO-111005-3	Zfish	PMID:21784840
Biological Process	GO:0048823	nucleate erythrocyte development	kmt2a	IMP	ZFIN:ZDB-MRPHLNO-111005-4	Zfish	PMID:21784840
Biological Process	GO:0048339	paraxial mesoderm development	kmt2a	IGI	ZFIN:ZDB-MRPHLNO-111005-2,ZFIN:ZDB-MRPHLNO-111005-5	Zfish	PMID:21784840
Biological Process	GO:0018026	peptidyl-lysine monomethylation	Kmt2a	IMP	MGI:MGI:3839794	Mouse	PMID:25834037
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KMT2A	IMP		Human	PMID:15960975
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Kmt2a	IDA		Mouse	MGI:MGI:5607228|PMID:21113167
Biological Process	GO:0010628	positive regulation of gene expression	Kmt2a	IMP		Rat	PMID:31570196|RGD:155888490
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KMT2A	IMP		Human	PMID:20010842
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KMT2A	IDA		Human	PMID:20861184
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Kmt2a	IMP		Mouse	MGI:MGI:2446369|PMID:12453418
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Kmt2a	IGI	MGI:MGI:1316736	Mouse	PMID:15640349
Biological Process	GO:0032411	positive regulation of transporter activity	KMT2A	IMP		Human	PMID:20861184
Biological Process	GO:0009791	post-embryonic development	Kmt2a	IGI	MGI:MGI:95559	Mouse	PMID:22674806
Biological Process	GO:0065003	protein-containing complex assembly	KMT2A	IDA		Human	PMID:15199122
Biological Process	GO:0010468	regulation of gene expression	Kmt2a	IMP	MGI:MGI:3839794	Mouse	PMID:25834037
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	Kmt2a	IMP	MGI:MGI:3839794	Mouse	PMID:25834037
Biological Process	GO:0009416	response to light stimulus	Kmt2a	IMP	MGI:MGI:3839794	Mouse	PMID:25834037
Biological Process	GO:0035864	response to potassium ion	Kmt2a	IEP		Rat	PMID:20211609|RGD:9588219
Biological Process	GO:0048536	spleen development	Kmt2a	IGI	MGI:MGI:95559	Mouse	PMID:22674806
Biological Process	GO:0045064	T-helper 2 cell differentiation	KMT2A	IDA		Human	PMID:20484083
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	KMT2A	IDA		Human	PMID:19556245
Biological Process	GO:0008542	visual learning	Kmt2a	IMP	MGI:MGI:3839794	Mouse	PMID:25834037

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern