Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KMT2D
  • Mouse genes Kmt2d
  • Rat genes
  • Zfish genes kmt2d
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kmt2d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Kmt2d	IDA		Mouse	MGI:MGI:6377809|PMID:26691508
Molecular Function	GO:0042800	histone H3K4 methyltransferase activity	Kmt2d	IMP		Mouse	MGI:MGI:4849597|PMID:20808952
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P61964	Human	PMID:15960975
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P03372	Human	PMID:16603732
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P61964	Human	PMID:17178841
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P61964	Human	PMID:17500065
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P61964	Human	PMID:22266653
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P61964	Human	PMID:22665483
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P10275	Human	PMID:22722839
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P61964	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:Q9UBL3-3	Human	PMID:26886794
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P61964	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	KMT2D	IPI	UniProtKB:P10275	Human	PMID:33640491
Molecular Function	GO:0005515	protein binding	Kmt2d	IPI	PR:Q9JL19	Mouse	PMID:17021013
Molecular Function	GO:0000976	transcription cis-regulatory region binding	KMT2D	IDA		Human	PMID:16603732
Cellular Component	GO:0044666	MLL3/4 complex	KMT2D	IPI		Human	PMID:23508102
Cellular Component	GO:0044666	MLL3/4 complex	KMT2D	IDA		Human	PMID:17500065
Biological Process	GO:0001568	blood vessel development	kmt2d	IMP	ZFIN:ZDB-GENO-220512-7	Zfish	PMID:31479440
Biological Process	GO:0007420	brain development	kmt2d	IMP	ZFIN:ZDB-MRPHLNO-150930-3,ZFIN:ZDB-MRPHLNO-150930-5	Zfish	PMID:25972376
Biological Process	GO:0003428	chondrocyte intercalation involved in growth plate cartilage morphogenesis	kmt2d	IMP	ZFIN:ZDB-MRPHLNO-151208-3	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	kmt2d	IMP	ZFIN:ZDB-MRPHLNO-151208-3	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	kmt2d	IMP	ZFIN:ZDB-MRPHLNO-151208-4	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	kmt2d	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2,ZFIN:ZDB-MRPHLNO-151208-3	Zfish	PMID:26280580
Biological Process	GO:0060027	convergent extension involved in gastrulation	kmt2d	IMP	ZFIN:ZDB-MRPHLNO-151208-3	Zfish	PMID:30018450
Biological Process	GO:1904888	cranial skeletal system development	kmt2d	IMP	ZFIN:ZDB-GENO-220512-7	Zfish	PMID:31479440
Biological Process	GO:0061371	determination of heart left/right asymmetry	kmt2d	IMP	ZFIN:ZDB-CRISPR-210719-2	Zfish	PMID:32738303
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	kmt2d	IMP	ZFIN:ZDB-GENO-181107-1	Zfish	PMID:30018450
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	kmt2d	IMP	ZFIN:ZDB-MRPHLNO-151208-3	Zfish	PMID:30018450
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	kmt2d	IMP	ZFIN:ZDB-MRPHLNO-150930-3,ZFIN:ZDB-MRPHLNO-150930-5	Zfish	PMID:25972376
Biological Process	GO:0007507	heart development	kmt2d	IMP	ZFIN:ZDB-GENO-220512-7	Zfish	PMID:31479440
Biological Process	GO:0007507	heart development	kmt2d	IMP	ZFIN:ZDB-MRPHLNO-150930-3,ZFIN:ZDB-MRPHLNO-150930-5	Zfish	PMID:25972376
Biological Process	GO:0031507	heterochromatin formation	Kmt2d	IMP		Mouse	MGI:MGI:4849597|PMID:20808952
Biological Process	GO:0001701	in utero embryonic development	Kmt2d	IMP	MGI:MGI:3623309	Mouse	PMID:16540515
Biological Process	GO:0001555	oocyte growth	Kmt2d	IMP		Mouse	MGI:MGI:4849597|PMID:20808952
Biological Process	GO:0048477	oogenesis	Kmt2d	IMP		Mouse	MGI:MGI:4849597|PMID:20808952
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	kmt2d	IMP	ZFIN:ZDB-GENO-220512-7	Zfish	PMID:31479440
Biological Process	GO:0008284	positive regulation of cell population proliferation	KMT2D	IMP		Human	PMID:16603732
Biological Process	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	KMT2D	IMP		Human	PMID:16603732
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KMT2D	IMP		Human	PMID:16603732
Biological Process	GO:0010468	regulation of gene expression	Kmt2d	IMP		Mouse	PMID:17021013
Biological Process	GO:0043627	response to estrogen	KMT2D	IDA		Human	PMID:16603732

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern