Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KMT5A
  • Mouse genes Kmt5a
  • Rat genes Kmt5a,RGD1561318
  • Zfish genes kmt5aa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kmt5a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042799	histone H4K20 methyltransferase activity	KMT5A	IDA		Human	PMID:27338793
Molecular Function	GO:0042054	histone methyltransferase activity	KMT5A	IDA		Human	PMID:17707234
Molecular Function	GO:0005515	protein binding	KMT5A	IPI	UniProtKB:P62805	Human	PMID:15933069
Molecular Function	GO:0005515	protein binding	KMT5A	IPI	UniProtKB:P04637	Human	PMID:17707234
Molecular Function	GO:0005515	protein binding	KMT5A	IPI	UniProtKB:Q9Y468	Human	PMID:18408754
Molecular Function	GO:0005515	protein binding	KMT5A	IPI	UniProtKB:P62805	Human	PMID:21983900
Molecular Function	GO:0005515	protein binding	KMT5A	IPI	UniProtKB:Q15672	Human	PMID:21983900
Molecular Function	GO:0005515	protein binding	KMT5A	IPI	UniProtKB:P07910	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KMT5A	IPI	UniProtKB:P62805	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	KMT5A	IPI	UniProtKB:P07910	Human	PMID:30021884
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity	KMT5A	IDA		Human	PMID:17707234
Molecular Function	GO:0003714	transcription corepressor activity	KMT5A	IDA		Human	PMID:18408754
Cellular Component	GO:0000785	chromatin	KMT5A	IDA		Human	PMID:27338793
Cellular Component	GO:0005829	cytosol	KMT5A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KMT5A	IDA		Human	GO_REF:0000052
Biological Process	GO:0009953	dorsal/ventral pattern formation	kmt5aa	IGI	ZFIN:ZDB-MRPHLNO-041217-12,ZFIN:ZDB-MRPHLNO-041217-13,ZFIN:ZDB-MRPHLNO-110401-1	Zfish	PMID:21282610
Biological Process	GO:0009953	dorsal/ventral pattern formation	kmt5aa	IMP	ZFIN:ZDB-MRPHLNO-110401-1	Zfish	PMID:21282610
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	KMT5A	IDA		Human	PMID:18474616
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	KMT5A	IDA		Human	PMID:27338793
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	KMT5A	IMP		Human	PMID:17707234
Biological Process	GO:0018026	peptidyl-lysine monomethylation	KMT5A	IDA		Human	PMID:17707234
Biological Process	GO:0010628	positive regulation of gene expression	kmt5aa	IGI	ZFIN:ZDB-MRPHLNO-041217-12,ZFIN:ZDB-MRPHLNO-041217-13,ZFIN:ZDB-MRPHLNO-110401-1	Zfish	PMID:21282610
Biological Process	GO:0010628	positive regulation of gene expression	kmt5aa	IMP	ZFIN:ZDB-MRPHLNO-110401-1	Zfish	PMID:21282610
Biological Process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	KMT5A	IMP		Human	PMID:17707234

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern