Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KNG1
  • Mouse genes Kng2
  • Rat genes Kng1,Kng2,Kng2l1
  • Zfish genes kng1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kng2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	KNG1	IDA		Human	PMID:3488317
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	Kng2	IDA		Rat	PMID:3356189|RGD:1600550
Molecular Function	GO:0005179	hormone activity	KNG1	IDA		Human	PMID:1314587
Molecular Function	GO:0005179	hormone activity	KNG1	IDA		Human	PMID:1329734
Molecular Function	GO:0002020	protease binding	Kng2	IPI	RGD:2447	Rat	PMID:3356189|RGD:1600550
Molecular Function	GO:0002020	protease binding	Kng2	IPI	RGD:2448	Rat	PMID:3356189|RGD:1600550
Molecular Function	GO:0002020	protease binding	Kng2	IPI	RGD:621509	Rat	PMID:3356189|RGD:1600550
Molecular Function	GO:0005515	protein binding	KNG1	IPI	UniProtKB:Q10714	Human	PMID:23082758
Molecular Function	GO:0005515	protein binding	KNG1	IPI	UniProtKB:Q07021	Human	PMID:8710908
Molecular Function	GO:0005102	signaling receptor binding	KNG1	IPI	UniProtKB:P04264	Human	PMID:11290596
Molecular Function	GO:0005102	signaling receptor binding	KNG1	IPI	UniProtKB:Q03405	Human	PMID:11290596
Cellular Component	GO:0072562	blood microparticle	KNG1	HDA		Human	PMID:22516433
Cellular Component	GO:0062023	collagen-containing extracellular matrix	KNG1	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	KNG1	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	KNG1	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Kng2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0070062	extracellular exosome	KNG1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	KNG1	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	KNG1	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	KNG1	IDA		Human	PMID:3488317
Cellular Component	GO:0005615	extracellular space	Kng2	IDA		Rat	PMID:15664626|RGD:1600455
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Kng2	IDA		Rat	PMID:1639765|RGD:1600542
Cellular Component	GO:0043204	perikaryon	Kng2	IDA		Rat	PMID:1611479|RGD:1600543
Biological Process	GO:1904888	cranial skeletal system development	kng1	IMP	ZFIN:ZDB-MRPHLNO-160801-2	Zfish	PMID:25043181
Biological Process	GO:1904888	cranial skeletal system development	kng1	IMP	ZFIN:ZDB-MRPHLNO-160801-1	Zfish	PMID:25043181
Biological Process	GO:0002542	Factor XII activation	Kng2	IDA		Rat	PMID:6685967|RGD:11062094
Biological Process	GO:0006954	inflammatory response	Kng2	IEP		Rat	PMID:1996642|RGD:11059895
Biological Process	GO:0030195	negative regulation of blood coagulation	KNG1	IDA		Human	PMID:11970955
Biological Process	GO:0007162	negative regulation of cell adhesion	KNG1	IDA		Human	PMID:11970955
Biological Process	GO:0050672	negative regulation of lymphocyte proliferation	Kng2	IDA		Rat	PMID:16140359|RGD:1600541
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Kng2	IDA		Rat	PMID:16140359|RGD:1600541
Biological Process	GO:0045861	negative regulation of proteolysis	KNG1	IDA		Human	PMID:3488317
Biological Process	GO:0045861	negative regulation of proteolysis	Kng2	IDA		Rat	PMID:3356189|RGD:1600550
Biological Process	GO:0042130	negative regulation of T cell proliferation	Kng2	IDA		Rat	PMID:16140359|RGD:1600541
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	KNG1	IDA		Human	PMID:16014619
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	Kng2	IDA		Rat	PMID:16378635|RGD:1600546
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Kng2	IDA		Rat	PMID:15664626|RGD:1600455
Biological Process	GO:0043410	positive regulation of MAPK cascade	Kng2	IDA		Rat	PMID:15664626|RGD:1600455
Biological Process	GO:0052548	regulation of endopeptidase activity	Kng2	IDA		Rat	PMID:3356189|RGD:1600550
Biological Process	GO:0042311	vasodilation	KNG1	IDA		Human	PMID:4322742
Biological Process	GO:0042311	vasodilation	KNG1	IDA		Human	PMID:6055465

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern