Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KREMEN1
  • Mouse genes Kremen1
  • Rat genes Kremen1
  • Zfish genes kremen1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kremen1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	KREMEN1	IPI	UniProtKB:O75581	Human	PMID:17804805
Molecular Function	GO:0005515	protein binding	KREMEN1	IPI	UniProtKB:O94907	Human	PMID:17804805
Molecular Function	GO:0005515	protein binding	KREMEN1	IPI	UniProtKB:Q2MKA7	Human	PMID:17804805
Cellular Component	GO:0043025	neuronal cell body	Kremen1	IDA		Mouse	MGI:MGI:6274963|PMID:24167472
Biological Process	GO:0001525	angiogenesis	kremen1	IGI	ZFIN:ZDB-MRPHLNO-111104-11,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0048903	anterior lateral line neuromast hair cell differentiation	kremen1	IMP	ZFIN:ZDB-GENO-161220-12	Zfish	PMID:27550540
Biological Process	GO:0006915	apoptotic process	Kremen1	IMP		Mouse	MGI:MGI:5883198|PMID:26206087
Biological Process	GO:0060173	limb development	Kremen1	IMP		Mouse	MGI:MGI:3803396|PMID:18505822
Biological Process	GO:0001889	liver development	kremen1	IGI	ZFIN:ZDB-GENE-040426-2209	Zfish	PMID:23484855
Biological Process	GO:0048681	negative regulation of axon regeneration	Kremen1	IMP		Mouse	MGI:MGI:6274963|PMID:24167472
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Kremen1	IMP		Mouse	MGI:MGI:5883198|PMID:26206087
Biological Process	GO:0030279	negative regulation of ossification	Kremen1	IMP		Mouse	MGI:MGI:3803396|PMID:18505822
Biological Process	GO:0048884	neuromast development	kremen1	IMP	ZFIN:ZDB-MRPHLNO-131119-10	Zfish	PMID:23891113
Biological Process	GO:0048916	posterior lateral line development	kremen1	IMP	ZFIN:ZDB-GENO-141113-8	Zfish	PMID:25038040

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern