Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KRIT1
  • Mouse genes Krit1
  • Rat genes Krit1
  • Zfish genes krit1,lmtk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Krit1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008017	microtubule binding	KRIT1	IDA		Human	PMID:17916086
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	KRIT1	IDA		Human	PMID:17916086
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9BSQ5	Human	PMID:16037064
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9BSQ5	Human	PMID:17657516
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:O14713	Human	PMID:17916086
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:P62834	Human	PMID:17916086
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:P33151	Human	PMID:20332120
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9BSQ5	Human	PMID:23007647
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9ULI3	Human	PMID:23007647
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9BSQ5	Human	PMID:25525273
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:O14713	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9BSQ5	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:O14713	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9BSQ5	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9ULI3	Human	PMID:26780829
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:Q9BSQ5-1	Human	PMID:27027284
Molecular Function	GO:0005515	protein binding	KRIT1	IPI	UniProtKB:P61086	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Krit1	IPI	UniProtKB:Q15036	Mouse	MGI:MGI:4943403|PMID:16712798
Molecular Function	GO:0005515	protein binding	Krit1	IPI	UniProtKB:Q9ULI3	Mouse	PMID:19151727
Molecular Function	GO:0005515	protein binding	Krit1	IPI	PR:Q8VCC6	Mouse	PMID:22898778
Molecular Function	GO:0005515	protein binding	Krit1	IPI	PR:Q920Q8	Mouse	PMID:22970292
Molecular Function	GO:0005515	protein binding	Krit1	IPI	PR:Q8K2Y9	Mouse	PMID:22898778
Cellular Component	GO:0005911	cell-cell junction	KRIT1	IDA		Human	PMID:20332120
Cellular Component	GO:0005911	cell-cell junction	KRIT1	IDA		Human	PMID:23007647
Cellular Component	GO:0005737	cytoplasm	Krit1	IDA		Mouse	PMID:22970292
Cellular Component	GO:0005615	extracellular space	KRIT1	HDA		Human	PMID:22664934
Cellular Component	GO:0005886	plasma membrane	KRIT1	IDA		Human	PMID:17916086
Cellular Component	GO:0032991	protein-containing complex	Krit1	IDA		Mouse	PMID:19151727
Biological Process	GO:0001525	angiogenesis	krit1	IMP	ZFIN:ZDB-MRPHLNO-060821-1	Zfish	PMID:21562623
Biological Process	GO:0001525	angiogenesis	krit1	IMP	ZFIN:ZDB-GENO-110725-6	Zfish	PMID:21562623
Biological Process	GO:0001525	angiogenesis	krit1	IMP	ZFIN:ZDB-GENO-110118-2	Zfish	PMID:20926893
Biological Process	GO:0001525	angiogenesis	krit1	IMP	ZFIN:ZDB-MRPHLNO-060821-2	Zfish	PMID:21562623
Biological Process	GO:0009948	anterior/posterior axis specification	krit1	IGI	ZFIN:ZDB-GENO-160218-9,ZFIN:ZDB-MRPHLNO-160205-1	Zfish	PMID:26540726
Biological Process	GO:0003181	atrioventricular valve morphogenesis	krit1	IMP	ZFIN:ZDB-GENO-980202-1023	Zfish	PMID:29364115
Biological Process	GO:0001568	blood vessel development	krit1	IMP	ZFIN:ZDB-MRPHLNO-060821-1	Zfish	PMID:24990152
Biological Process	GO:0072554	blood vessel lumenization	krit1	IMP	ZFIN:ZDB-GENO-110118-2	Zfish	PMID:20926893
Biological Process	GO:0048514	blood vessel morphogenesis	krit1	IMP	ZFIN:ZDB-GENO-080318-5	Zfish	PMID:17531218
Biological Process	GO:0045454	cell redox homeostasis	KRIT1	IMP		Human	PMID:20668652
Biological Process	GO:0045454	cell redox homeostasis	Krit1	IMP		Mouse	MGI:MGI:4821024|PMID:20668652
Biological Process	GO:0001886	endothelial cell morphogenesis	krit1	IMP	ZFIN:ZDB-GENO-081111-1	Zfish	PMID:18469344
Biological Process	GO:0060047	heart contraction	krit1	IGI	ZFIN:ZDB-GENO-160218-9,ZFIN:ZDB-MRPHLNO-160205-1	Zfish	PMID:26540726
Biological Process	GO:0007507	heart development	krit1	IGI	ZFIN:ZDB-MRPHLNO-220309-1,ZFIN:ZDB-MRPHLNO-220309-3,ZFIN:ZDB-MRPHLNO-220309-4	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	krit1	IGI	ZFIN:ZDB-MRPHLNO-220309-1,ZFIN:ZDB-MRPHLNO-121102-1,ZFIN:ZDB-MRPHLNO-220309-2	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	krit1	IMP	ZFIN:ZDB-MRPHLNO-220309-1	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	krit1	IGI	ZFIN:ZDB-MRPHLNO-220309-1,ZFIN:ZDB-MRPHLNO-220309-5	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	krit1	IMP	ZFIN:ZDB-MRPHLNO-060821-1	Zfish	PMID:16873582
Biological Process	GO:0007507	heart development	krit1	IMP	ZFIN:ZDB-MRPHLNO-060821-2	Zfish	PMID:23007647
Biological Process	GO:0007507	heart development	krit1	IMP	ZFIN:ZDB-MRPHLNO-060821-2	Zfish	PMID:16873582
Biological Process	GO:0007507	heart development	krit1	IGI	ZFIN:ZDB-GENO-160218-9,ZFIN:ZDB-MRPHLNO-160205-1	Zfish	PMID:26540726
Biological Process	GO:0007507	heart development	krit1	IMP	ZFIN:ZDB-GENO-980202-269	Zfish	PMID:16873582
Biological Process	GO:0003007	heart morphogenesis	krit1	IMP	ZFIN:ZDB-GENO-190521-7	Zfish	PMID:30030370
Biological Process	GO:0003007	heart morphogenesis	krit1	IGI	ZFIN:ZDB-GENE-100712-2	Zfish	PMID:30030370
Biological Process	GO:0003007	heart morphogenesis	krit1	IMP	ZFIN:ZDB-GENO-080318-5	Zfish	PMID:17531218
Biological Process	GO:0003007	heart morphogenesis	krit1	IGI	ZFIN:ZDB-MRPHLNO-060821-1,ZFIN:ZDB-MRPHLNO-130531-2	Zfish	PMID:23328253
Biological Process	GO:0003007	heart morphogenesis	krit1	IMP	ZFIN:ZDB-GENO-070808-11	Zfish	PMID:9007249
Biological Process	GO:0003007	heart morphogenesis	krit1	IGI	ZFIN:ZDB-MRPHLNO-060821-1,ZFIN:ZDB-MRPHLNO-130531-1	Zfish	PMID:23328253
Biological Process	GO:0003007	heart morphogenesis	krit1	IMP	ZFIN:ZDB-GENO-980202-1023	Zfish	PMID:9007249
Biological Process	GO:0033622	integrin activation	KRIT1	IDA		Human	PMID:23317506
Biological Process	GO:0016525	negative regulation of angiogenesis	KRIT1	IMP		Human	PMID:20616044
Biological Process	GO:0016525	negative regulation of angiogenesis	Krit1	IMP		Mouse	MGI:MGI:4943808|PMID:20616044
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	KRIT1	IMP		Human	PMID:20616044
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	krit1	IMP	ZFIN:ZDB-GENO-080318-5	Zfish	PMID:17531218
Biological Process	GO:0010596	negative regulation of endothelial cell migration	KRIT1	IMP		Human	PMID:20616044
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	KRIT1	IMP		Human	PMID:20616044
Biological Process	GO:0032092	positive regulation of protein binding	Krit1	IDA		Mouse	PMID:19151727
Biological Process	GO:2000114	regulation of establishment of cell polarity	KRIT1	IMP		Human	PMID:20332120
Biological Process	GO:2000114	regulation of establishment of cell polarity	Krit1	IMP		Mouse	MGI:MGI:4943837|PMID:20332120
Biological Process	GO:0007033	vacuole organization	krit1	IMP	ZFIN:ZDB-GENO-110118-2	Zfish	PMID:20926893
Biological Process	GO:0001570	vasculogenesis	krit1	IMP	ZFIN:ZDB-GENO-081111-1	Zfish	PMID:18469344
Biological Process	GO:0001570	vasculogenesis	krit1	IMP	ZFIN:ZDB-MRPHLNO-081111-1	Zfish	PMID:18469344

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern