Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KRT1
  • Mouse genes Krt1
  • Rat genes Krt1
  • Zfish genes krt4,krt5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Krt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030246	carbohydrate binding	KRT1	IPI	UniProtKB:P11226	Human	PMID:11549596
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P01042	Human	PMID:11290596
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P58107	Human	PMID:16923132
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P13645	Human	PMID:24940650
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q15149	Human	PMID:24940650
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P14373	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P19012	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P37198	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q08379	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q14525	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P13645	Human	PMID:27595935
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:O15552	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:O76013-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:O76014	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:O76015	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P02533	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P08727	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P08779	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P13646	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P19012	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:P37198	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q01081	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q08379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q14525	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q2M2I5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q6A163	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q6NUQ1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q7Z3Y7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q7Z3Y8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q7Z3Y9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q7Z3Z0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q92764	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q96CS2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q96ED9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q96MV1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q9BYV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q9NP66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q9UBB9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT1	IPI	UniProtKB:Q9Y2J4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Krt1	IPI	UniProtKB:Q61781	Mouse	MGI:MGI:2179054|PMID:11408584
Molecular Function	GO:0005515	protein binding	Krt1	IPI	UniProtKB:P02535|UniProtKB:Q9QXS1	Mouse	MGI:MGI:7260090|PMID:24940650
Molecular Function	GO:0046982	protein heterodimerization activity	KRT1	IDA		Human	PMID:27595935
Molecular Function	GO:0030280	structural constituent of skin epidermis	KRT1	IDA		Human	PMID:7543090
Cellular Component	GO:0072562	blood microparticle	KRT1	HDA		Human	PMID:22516433
Cellular Component	GO:0062023	collagen-containing extracellular matrix	KRT1	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Krt1	HDA		Mouse	MGI:MGI:5582867|PMID:23658023
Cellular Component	GO:0001533	cornified envelope	KRT1	IDA		Human	PMID:7543090
Cellular Component	GO:0001533	cornified envelope	Krt1	IDA		Mouse	PMID:26644517
Cellular Component	GO:0005737	cytoplasm	KRT1	IDA		Human	PMID:32179842
Cellular Component	GO:0070062	extracellular exosome	KRT1	HDA		Human	PMID:11487543
Cellular Component	GO:0070062	extracellular exosome	KRT1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	KRT1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	KRT1	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	KRT1	HDA		Human	PMID:23580065
Cellular Component	GO:0045095	keratin filament	KRT1	IPI		Human	PMID:27595935
Cellular Component	GO:0045095	keratin filament	Krt1	IDA		Mouse	PMID:2404337
Cellular Component	GO:0016020	membrane	KRT1	IDA		Human	PMID:11290596
Cellular Component	GO:0016020	membrane	KRT1	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	KRT1	HDA		Human	PMID:21630459
Biological Process	GO:0001867	complement activation, lectin pathway	KRT1	IPI	UniProtKB:P11226	Human	PMID:11549596
Biological Process	GO:0061436	establishment of skin barrier	Krt1	IMP	MGI:MGI:5495252	Mouse	PMID:23132931
Biological Process	GO:0031101	fin regeneration	krt5	IEP		Zfish	PMID:22278371
Biological Process	GO:0050728	negative regulation of inflammatory response	Krt1	IGI	MGI:MGI:107936	Mouse	PMID:23132931
Biological Process	GO:0050728	negative regulation of inflammatory response	Krt1	IMP	MGI:MGI:5495252	Mouse	PMID:23132931
Biological Process	GO:0018149	peptide cross-linking	KRT1	IDA		Human	PMID:7543090
Biological Process	GO:0051290	protein heterotetramerization	KRT1	IDA		Human	PMID:27595935
Biological Process	GO:0001895	retina homeostasis	KRT1	HEP		Human	PMID:23580065

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern