Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KRT18
  • Mouse genes Krt18
  • Rat genes Krt18
  • Zfish genes krt18a.1,krt18b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Krt18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098641	cadherin binding involved in cell-cell adhesion	KRT18	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q13835-2	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:O75190	Human	PMID:10954706
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P02671	Human	PMID:10954706
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787	Human	PMID:10954706
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P27348	Human	PMID:10954706
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787	Human	PMID:11684708
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q15628	Human	PMID:11684708
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:B7UM99	Human	PMID:14710194
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787	Human	PMID:14756564
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787,UniProtKB:P58107	Human	PMID:15671067
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q9BT92	Human	PMID:15731013
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P27958:PRO_0000037566	Human	PMID:15846844
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:O14964	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q9Y5B8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:B7UM99	Human	PMID:16367866
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q99816	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q9BQ69	Human	PMID:20035625
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q9Y6K9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q14457	Human	PMID:23112296
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787	Human	PMID:24940650
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q15149	Human	PMID:24940650
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q08379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q8IYE0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q96CS2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:O14964	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q08379	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q8N0S2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:O75022	Human	PMID:26769854
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:A0A0S2Z4Q4	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:A0A0S2Z505	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P07196	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P48668	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q08379	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P02538	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P05787	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P48668	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q14533	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q3SY84	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q5JVL4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q5XKE5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q8TD31-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q8WW24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q99816	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q9BVG8-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q9NX04	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q9P2K3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:Q9Y5B8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT18	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Krt18	IPI	UniProtKB:Q8R0W0	Mouse	MGI:MGI:5805359|PMID:25617501
Molecular Function	GO:0005515	protein binding	Krt18	IPI	UniProtKB:P11679|UniProtKB:Q9QXS1	Mouse	MGI:MGI:7260090|PMID:24940650
Molecular Function	GO:0005515	protein binding	Krt18	IPI	PR:P50284	Mouse	PMID:10747083
Molecular Function	GO:0005515	protein binding	Krt18	IPI	PR:P25119	Mouse	PMID:10747083
Molecular Function	GO:0003723	RNA binding	KRT18	HDA		Human	PMID:22658674
Molecular Function	GO:0097110	scaffold protein binding	KRT18	IPI	UniProtKB:Q13835	Human	PMID:10852826
Molecular Function	GO:0097110	scaffold protein binding	KRT18	IPI	UniProtKB:Q99959	Human	PMID:10852826
Cellular Component	GO:0005912	adherens junction	KRT18	HDA		Human	PMID:25468996
Cellular Component	GO:0071944	cell periphery	Krt18	IDA		Mouse	PMID:23284756
Cellular Component	GO:0034451	centriolar satellite	KRT18	IDA		Human	PMID:18000879
Cellular Component	GO:0005737	cytoplasm	KRT18	IDA		Human	PMID:16424149
Cellular Component	GO:0005737	cytoplasm	KRT18	IDA		Human	PMID:20346438
Cellular Component	GO:0005737	cytoplasm	Krt18	IDA		Rat	PMID:30563999|RGD:27226806
Cellular Component	GO:0005829	cytosol	KRT18	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	Krt18	IDA		Rat	PMID:9353322|RGD:27226807
Cellular Component	GO:0070062	extracellular exosome	KRT18	HDA		Human	PMID:19199708
Cellular Component	GO:0005615	extracellular space	Krt18	IDA		Rat	PMID:24071521|RGD:27226810
Cellular Component	GO:0005615	extracellular space	Krt18	IDA		Rat	PMID:29989845|RGD:26884460
Cellular Component	GO:0005615	extracellular space	Krt18	IDA		Rat	PMID:30149902|RGD:18337497
Cellular Component	GO:0005882	intermediate filament	KRT18	IDA		Human	PMID:10852826
Cellular Component	GO:0005882	intermediate filament	Krt18	IDA		Mouse	PMID:10747083
Cellular Component	GO:0045095	keratin filament	KRT18	IPI		Human	PMID:10852826
Cellular Component	GO:0045095	keratin filament	KRT18	IDA		Human	PMID:16424149
Cellular Component	GO:0045095	keratin filament	Krt18	IDA		Mouse	PMID:21930775
Cellular Component	GO:0045095	keratin filament	Krt18	IDA		Rat	PMID:1709097|RGD:1624319
Cellular Component	GO:0005815	microtubule organizing center	KRT18	IDA		Human	PMID:18000879
Cellular Component	GO:0005886	plasma membrane	Krt18	IDA		Rat	PMID:21138630|RGD:27226809
Cellular Component	GO:0032991	protein-containing complex	Krt18	IDA		Rat	PMID:9353322|RGD:27226807
Biological Process	GO:1902488	cholangiocyte apoptotic process	Krt18	IEP		Rat	PMID:30563999|RGD:27226806
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Krt18	IMP	MGI:MGI:2178045	Mouse	PMID:10747083
Biological Process	GO:0043001	Golgi to plasma membrane protein transport	KRT18	IDA		Human	PMID:15529338
Biological Process	GO:0097284	hepatocyte apoptotic process	Krt18	IMP	MGI:MGI:2178045	Mouse	PMID:10747083
Biological Process	GO:0070365	hepatocyte differentiation	Krt18	IEP		Rat	PMID:24340101|RGD:27226712
Biological Process	GO:0070365	hepatocyte differentiation	Krt18	IEP		Rat	PMID:28941653|RGD:27226713
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	KRT18	IDA		Human	PMID:20346438
Biological Process	GO:0072497	mesenchymal stem cell differentiation	Krt18	IEP		Rat	PMID:18484094|RGD:27226811
Biological Process	GO:0043066	negative regulation of apoptotic process	KRT18	IDA		Human	PMID:11684708
Biological Process	GO:0009750	response to fructose	Krt18	IEP		Rat	PMID:29989845|RGD:26884460
Biological Process	GO:0031667	response to nutrient levels	Krt18	IEP		Rat	PMID:24071521|RGD:27226810
Biological Process	GO:0031667	response to nutrient levels	Krt18	IEP		Rat	PMID:30149902|RGD:18337497
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	Krt18	IGI	MGI:MGI:96705	Mouse	PMID:10747083

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern