Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KRT2
  • Mouse genes Krt2
  • Rat genes Krt2
  • Zfish genes krt4,krt5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Krt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008092	cytoskeletal protein binding	Krt2	IMP	MGI:MGI:4363845	Mouse	PMID:24751727
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:A1A4E9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:O76015	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P08727	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:O76015	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P08727	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P13646	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P19012	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q15323	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q6A162	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:O76015	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:O76015	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P08727	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P13646	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:O76013-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P08727	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P08779	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:P19012	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q14525	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q6A162	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q7Z3Y8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q7Z3Z0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT2	IPI	UniProtKB:Q92764	Human	PMID:32296183
Molecular Function	GO:0030280	structural constituent of skin epidermis	KRT2	IDA		Human	PMID:7543090
Molecular Function	GO:0030280	structural constituent of skin epidermis	Krt2	IMP	MGI:MGI:4363845	Mouse	PMID:24751727
Cellular Component	GO:0001533	cornified envelope	KRT2	IDA		Human	PMID:7543090
Cellular Component	GO:0005737	cytoplasm	KRT2	IDA		Human	PMID:32179842
Cellular Component	GO:0005737	cytoplasm	Krt2	IDA		Mouse	MGI:MGI:5603985|PMID:24751727
Cellular Component	GO:0070062	extracellular exosome	KRT2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	KRT2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	KRT2	HDA		Human	PMID:23580065
Cellular Component	GO:0045095	keratin filament	Krt2	IDA		Mouse	PMID:24751727
Cellular Component	GO:0016020	membrane	KRT2	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	KRT2	HDA		Human	PMID:21630459
Biological Process	GO:0008544	epidermis development	Krt2	IMP	MGI:MGI:4363845	Mouse	PMID:24751727
Biological Process	GO:0031101	fin regeneration	krt5	IEP		Zfish	PMID:22278371
Biological Process	GO:0045109	intermediate filament organization	Krt2	IMP	MGI:MGI:4363845	Mouse	PMID:24751727
Biological Process	GO:0031424	keratinization	KRT2	IDA		Human	PMID:12598329
Biological Process	GO:0032980	keratinocyte activation	KRT2	IDA		Human	PMID:12598329
Biological Process	GO:0003334	keratinocyte development	Krt2	IMP	MGI:MGI:4363845	Mouse	PMID:24751727
Biological Process	GO:0051546	keratinocyte migration	KRT2	IDA		Human	PMID:15737202
Biological Process	GO:0043616	keratinocyte proliferation	KRT2	IDA		Human	PMID:12598329
Biological Process	GO:0018149	peptide cross-linking	KRT2	IDA		Human	PMID:7543090
Biological Process	GO:0045684	positive regulation of epidermis development	Krt2	IMP		Mouse	MGI:MGI:6107675|PMID:26603179

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern