Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KRT8
  • Mouse genes Krt8
  • Rat genes Krt8
  • Zfish genes krt4,krt5,krt8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Krt8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q13835-2	Human	PMID:10852826
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783	Human	PMID:10954706
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783	Human	PMID:11684708
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P62993	Human	PMID:12577067
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783	Human	PMID:14756564
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783,UniProtKB:P58107	Human	PMID:15671067
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q9BT92	Human	PMID:15731013
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P08670	Human	PMID:15846844
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P27958:PRO_0000037566	Human	PMID:15846844
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P35900	Human	PMID:16608857
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P27695	Human	PMID:19188445
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P62993	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q99527	Human	PMID:21149639
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q9Y6K9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P13569	Human	PMID:22038833
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P14079	Human	PMID:22458338
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783	Human	PMID:24940650
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q15149	Human	PMID:24940650
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:A1A4E9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:O76015	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P19012	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q9UBB9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:O75022	Human	PMID:26769854
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P08670	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:O76015	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:O76013-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:O76015	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P05783	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P08727	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P08779	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:P19012	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q14525	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q2M2I5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q6A162	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q7Z3Y7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q7Z3Y8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q7Z3Z0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q86XR8-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q92764	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KRT8	IPI	UniProtKB:Q9HC98-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Krt8	IPI	UniProtKB:P05784|UniProtKB:Q9QXS1	Mouse	MGI:MGI:7260090|PMID:24940650
Molecular Function	GO:0005515	protein binding	Krt8	IPI	UniProtKB:Q8R0W0	Mouse	MGI:MGI:5805359|PMID:25617501
Molecular Function	GO:0005515	protein binding	Krt8	IPI	UniProtKB:Q9D312	Mouse	MGI:MGI:3759340|PMID:12857878
Molecular Function	GO:0005515	protein binding	Krt8	IPI	PR:P50284	Mouse	PMID:10747083
Molecular Function	GO:0005515	protein binding	Krt8	IPI	RGD:619936	Rat	PMID:15247274|RGD:1600063
Molecular Function	GO:0005515	protein binding	Krt8	IPI	RGD:621890	Rat	PMID:15247274|RGD:1600063
Molecular Function	GO:0005515	protein binding	Krt8	IPI	UniProtKB:P11530	Rat	PMID:15247274|RGD:1600063
Molecular Function	GO:0044877	protein-containing complex binding	Krt8	IPI	RGD:2507|RGD:619936|RGD:621890	Rat	PMID:15247274|RGD:1600063
Molecular Function	GO:0097110	scaffold protein binding	KRT8	IPI	UniProtKB:Q13835	Human	PMID:10852826
Molecular Function	GO:0097110	scaffold protein binding	KRT8	IPI	UniProtKB:Q99959	Human	PMID:10852826
Cellular Component	GO:0016327	apicolateral plasma membrane	Krt8	IDA		Mouse	MGI:MGI:5635761|PMID:25232867
Cellular Component	GO:0071944	cell periphery	Krt8	IDA		Mouse	PMID:19487454
Cellular Component	GO:0005911	cell-cell junction	Krt8	IDA		Mouse	PMID:23266329
Cellular Component	GO:0043034	costamere	Krt8	IDA		Rat	PMID:15247274|RGD:1600063
Cellular Component	GO:0005737	cytoplasm	KRT8	IDA		Human	PMID:15846844
Cellular Component	GO:0005737	cytoplasm	KRT8	IDA		Human	PMID:19188445
Cellular Component	GO:0016010	dystrophin-associated glycoprotein complex	Krt8	IDA		Rat	PMID:15247274|RGD:1600063
Cellular Component	GO:0070062	extracellular exosome	KRT8	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	KRT8	HDA		Human	PMID:23533145
Cellular Component	GO:0005882	intermediate filament	KRT8	IDA		Human	PMID:10852826
Cellular Component	GO:0005882	intermediate filament	Krt8	IDA		Mouse	PMID:10747083
Cellular Component	GO:0045111	intermediate filament cytoskeleton	KRT8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045095	keratin filament	KRT8	IPI		Human	PMID:10852826
Cellular Component	GO:0045095	keratin filament	Krt8	IDA		Rat	PMID:1370816|RGD:633141
Cellular Component	GO:0045095	keratin filament	Krt8	IDA		Rat	PMID:1709097|RGD:1624319
Cellular Component	GO:0005634	nucleus	KRT8	HDA		Human	PMID:21630459
Cellular Component	GO:0042383	sarcolemma	Krt8	IDA		Mouse	PMID:15247274
Cellular Component	GO:0042383	sarcolemma	Krt8	IDA		Rat	PMID:15247274|RGD:1600063
Cellular Component	GO:0030018	Z disc	Krt8	IDA		Mouse	PMID:15247274
Cellular Component	GO:0030018	Z disc	Krt8	IDA		Rat	PMID:15247274|RGD:1600063
Biological Process	GO:0060706	cell differentiation involved in embryonic placenta development	Krt8	IGI	MGI:MGI:96693	Mouse	PMID:11062258
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Krt8	IMP	MGI:MGI:2178042	Mouse	PMID:10747083
Biological Process	GO:0031101	fin regeneration	krt5	IEP		Zfish	PMID:22278371
Biological Process	GO:0097284	hepatocyte apoptotic process	Krt8	IMP	MGI:MGI:2178042	Mouse	PMID:10747083
Biological Process	GO:0051599	response to hydrostatic pressure	Krt8	IDA		Rat	PMID:15972820|RGD:1581601
Biological Process	GO:0051707	response to other organism	Krt8	IMP	MGI:MGI:2178042	Mouse	PMID:14576356
Biological Process	GO:0045214	sarcomere organization	Krt8	IDA		Rat	PMID:15247274|RGD:1600063
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	Krt8	IGI	MGI:MGI:96692	Mouse	PMID:10747083
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	Krt8	IMP	MGI:MGI:2178042	Mouse	PMID:10747083

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern