Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KSR1
  • Mouse genes Ksr1
  • Rat genes Ksr1
  • Zfish genes ksr1a,ksr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ksr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	KSR1	IDA		Human	PMID:29433126
Molecular Function	GO:0071889	14-3-3 protein binding	Ksr1	IPI	UniProtKB:P62258	Mouse	MGI:MGI:5758853|PMID:10409742
Molecular Function	GO:0005524	ATP binding	KSR1	IDA		Human	PMID:29433126
Molecular Function	GO:0005524	ATP binding	Ksr1	IMP		Mouse	MGI:MGI:6355580|PMID:21441104
Molecular Function	GO:0051879	Hsp90 protein binding	Ksr1	IPI	UniProtKB:Q16543	Mouse	MGI:MGI:5758853|PMID:10409742
Molecular Function	GO:0005078	MAP-kinase scaffold activity	Ksr1	IMP		Mouse	MGI:MGI:5770064|PMID:21102438
Molecular Function	GO:0005078	MAP-kinase scaffold activity	Ksr1	IMP		Mouse	MGI:MGI:5758853|PMID:10409742
Molecular Function	GO:0005078	MAP-kinase scaffold activity	Ksr1	IDA		Mouse	PMID:19560418
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	Ksr1	IPI	UniProtKB:P36507|UniProtKB:Q02750	Mouse	MGI:MGI:5758853|PMID:10409742
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	Ksr1	IPI	RGD:61888	Rat	PMID:16272159|RGD:2298675
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	Ksr1	IPI	RGD:70495	Rat	PMID:16272159|RGD:2298675
Molecular Function	GO:0005515	protein binding	KSR1	IPI	UniProtKB:P36507	Human	PMID:11909642
Molecular Function	GO:0005515	protein binding	KSR1	IPI	UniProtKB:Q86Y07	Human	PMID:20679487
Molecular Function	GO:0005515	protein binding	KSR1	IDA		Human	PMID:22572157
Molecular Function	GO:0005515	protein binding	KSR1	IPI	UniProtKB:Q86Y07	Human	PMID:22752157
Molecular Function	GO:0005515	protein binding	KSR1	IPI	UniProtKB:P36507	Human	PMID:27086506
Molecular Function	GO:0005515	protein binding	KSR1	IPI	UniProtKB:P07900|UniProtKB:P15056|UniProtKB:P36507|UniProtKB:Q02750|UniProtKB:Q16543	Human	PMID:29433126
Molecular Function	GO:0005515	protein binding	KSR1	IPI	UniProtKB:P36507	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	KSR1	IPI	UniProtKB:P36507	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Ksr1	IPI	UniProtKB:P27448	Mouse	MGI:MGI:7310022|PMID:12941695
Molecular Function	GO:0005515	protein binding	Ksr1	IPI	UniProtKB:Q60875	Mouse	MGI:MGI:5568272|PMID:24525234
Molecular Function	GO:0005515	protein binding	Ksr1	IPI	UniProtKB:P15056	Mouse	MGI:MGI:5426077|PMID:22510884
Molecular Function	GO:0005515	protein binding	Ksr1	IPI	UniProtKB:Q86Y07-1	Mouse	MGI:MGI:5465525|PMID:22752157
Molecular Function	GO:0005515	protein binding	Ksr1	IPI	UniProtKB:P15531	Mouse	MGI:MGI:3763298|PMID:15684389
Molecular Function	GO:0004672	protein kinase activity	Ksr1	IMP		Mouse	MGI:MGI:6355580|PMID:21441104
Molecular Function	GO:0019901	protein kinase binding	Ksr1	IPI	UniProtKB:P28028|UniProtKB:Q02750	Mouse	MGI:MGI:6355580|PMID:21441104
Molecular Function	GO:0051087	protein-folding chaperone binding	Ksr1	IPI	UniProtKB:P07900	Mouse	MGI:MGI:5758853|PMID:10409742
Cellular Component	GO:0005829	cytosol	KSR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	KSR1	IDA		Human	PMID:22572157
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	KSR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	KSR1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	KSR1	IDA		Human	PMID:22572157
Cellular Component	GO:0032991	protein-containing complex	KSR1	IDA		Human	PMID:22572157
Biological Process	GO:0019933	cAMP-mediated signaling	Ksr1	IMP		Mouse	MGI:MGI:5770064|PMID:21102438
Biological Process	GO:0043410	positive regulation of MAPK cascade	KSR1	IDA		Human	PMID:29433126
Biological Process	GO:0043410	positive regulation of MAPK cascade	Ksr1	IMP		Mouse	MGI:MGI:6355580|PMID:21441104
Biological Process	GO:0043410	positive regulation of MAPK cascade	Ksr1	IMP		Mouse	MGI:MGI:5758853|PMID:10409742
Biological Process	GO:0043410	positive regulation of MAPK cascade	Ksr1	IMP		Mouse	MGI:MGI:5770064|PMID:21102438
Biological Process	GO:0043410	positive regulation of MAPK cascade	Ksr1	IDA		Mouse	PMID:19560418
Biological Process	GO:0007265	Ras protein signal transduction	Ksr1	IMP		Mouse	MGI:MGI:5770064|PMID:21102438
Biological Process	GO:0042127	regulation of cell population proliferation	Ksr1	IMP		Mouse	MGI:MGI:2668780|PMID:12874031
Biological Process	GO:0043405	regulation of MAP kinase activity	Ksr1	IMP		Mouse	MGI:MGI:2668780|PMID:12874031

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern