Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse L1cam

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes L1CAM
- Mouse genes L1cam
- Rat genes L1cam
- Zfish genes l1cama,l1camb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set L1cam

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	L1cam	IDA		Mouse	PMID:8557754
Molecular Function	GO:0042802	identical protein binding	L1cam	IDA		Mouse	PMID:9048906
Molecular Function	GO:0005178	integrin binding	L1cam	IDA		Mouse	PMID:8557754
Molecular Function	GO:0030165	PDZ domain binding	L1cam	IPI	RGD:621497	Rat	PMID:11152476\|RGD:633988
Molecular Function	GO:0005515	protein binding	L1CAM	IPI	UniProtKB:P26040	Human	PMID:18321067
Molecular Function	GO:0005515	protein binding	L1CAM	IPI	UniProtKB:P84091	Human	PMID:18321067
Molecular Function	GO:0005515	protein binding	L1cam	IPI	UniProtKB:P34152\|UniProtKB:Q8VI36	Mouse	MGI:MGI:3796794\|PMID:18464795
Molecular Function	GO:0005515	protein binding	L1cam	IPI	PR:Q61330	Mouse	PMID:18550718
Molecular Function	GO:0005515	protein binding	L1cam	IPI	PR:P97333	Mouse	PMID:18550718
Molecular Function	GO:0005515	protein binding	L1cam	IPI	PR:B9EKR1	Mouse	PMID:12700241
Molecular Function	GO:0005515	protein binding	L1cam	IPI	PR:P24807	Mouse	PMID:9048906
Molecular Function	GO:0005515	protein binding	L1cam	IPI	PR:P24807	Mouse	PMID:11283023
Molecular Function	GO:0005515	protein binding	L1cam	IPI	PR:P24807	Mouse	PMID:7613634
Molecular Function	GO:0005515	protein binding	L1cam	IPI	UniProtKB:A0MZ67	Rat	PMID:18519736\|RGD:10054086
Molecular Function	GO:0019904	protein domain specific binding	L1CAM	IDA		Human	PMID:18321067
Molecular Function	GO:0043621	protein self-association	L1cam	IPI	PR:P11627	Mouse	PMID:18550718
Molecular Function	GO:0033691	sialic acid binding	L1cam	IDA		Mouse	PMID:11283023
Molecular Function	GO:0033691	sialic acid binding	L1cam	IDA		Mouse	PMID:19458237
Cellular Component	GO:0030424	axon	L1CAM	IDA		Human	PMID:20621658
Cellular Component	GO:0030424	axon	L1cam	IDA		Rat	PMID:18299352\|RGD:9850091
Cellular Component	GO:0030424	axon	L1cam	IDA		Rat	PMID:22473424\|RGD:10411906
Cellular Component	GO:0044295	axonal growth cone	L1cam	IDA		Rat	PMID:15355311\|RGD:11570505
Cellular Component	GO:0044295	axonal growth cone	L1cam	IDA		Rat	PMID:18519736\|RGD:10054086
Cellular Component	GO:0009986	cell surface	L1CAM	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	L1CAM	IDA		Human	PMID:22973895
Cellular Component	GO:0009986	cell surface	L1cam	IDA		Mouse	PMID:12514225
Cellular Component	GO:0009986	cell surface	L1cam	IDA		Rat	PMID:18299352\|RGD:9850091
Cellular Component	GO:0062023	collagen-containing extracellular matrix	L1CAM	HDA		Human	PMID:27559042
Cellular Component	GO:0030425	dendrite	L1cam	IDA		Rat	PMID:18299352\|RGD:9850091
Cellular Component	GO:0044294	dendritic growth cone	L1cam	IDA		Rat	PMID:15355311\|RGD:11570505
Cellular Component	GO:0005768	endosome	L1cam	IDA		Rat	PMID:18299352\|RGD:9850091
Cellular Component	GO:0009897	external side of plasma membrane	L1cam	IDA		Mouse	PMID:8125140
Cellular Component	GO:0009897	external side of plasma membrane	L1cam	IDA		Mouse	PMID:7613634
Cellular Component	GO:0005925	focal adhesion	L1CAM	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	L1cam	IDA		Mouse	PMID:16537644
Cellular Component	GO:0016020	membrane	L1cam	IDA		Mouse	PMID:11283023
Cellular Component	GO:0045121	membrane raft	L1cam	IDA		Rat	PMID:21884525\|RGD:6483018
Cellular Component	GO:0043025	neuronal cell body	L1CAM	IDA		Human	PMID:20621658
Cellular Component	GO:0043025	neuronal cell body	L1cam	IDA		Rat	PMID:18299352\|RGD:9850091
Cellular Component	GO:0005886	plasma membrane	L1CAM	IDA		Human	PMID:20621658
Cellular Component	GO:0042734	presynaptic membrane	L1cam	IDA		Mouse	PMID:16537644
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	L1cam	IDA		Mouse	PMID:16537644
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	L1cam	EXP		Rat	PMID:7997264\|RGD:13702438
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	L1cam	IDA		Rat	PMID:7997264\|RGD:13702438
Cellular Component	GO:0043195	terminal bouton	L1cam	IDA		Mouse	PMID:16537644
Biological Process	GO:0061564	axon development	L1CAM	IDA		Human	PMID:20621658
Biological Process	GO:0007411	axon guidance	L1CAM	IDA		Human	PMID:24155914
Biological Process	GO:0007411	axon guidance	L1cam	IGI	MGI:MGI:107558	Mouse	PMID:18550718
Biological Process	GO:0007411	axon guidance	L1cam	IGI	MGI:MGI:104518	Mouse	PMID:18550718
Biological Process	GO:0007411	axon guidance	L1cam	IMP	MGI:MGI:1857443	Mouse	PMID:12533613
Biological Process	GO:0007411	axon guidance	L1cam	IMP	MGI:MGI:1857443	Mouse	PMID:18550718
Biological Process	GO:0007411	axon guidance	L1cam	IDA		Mouse	PMID:18650339
Biological Process	GO:0031103	axon regeneration	l1camb	IMP	ZFIN:ZDB-MRPHLNO-050628-1	Zfish	PMID:15356195
Biological Process	GO:0007413	axonal fasciculation	L1cam	IMP		Rat	PMID:3856258\|RGD:11570517
Biological Process	GO:0019722	calcium-mediated signaling	L1cam	IDA		Mouse	PMID:7613634
Biological Process	GO:0060536	cartilage morphogenesis	l1camb	IGI	ZFIN:ZDB-GENE-000920-1	Zfish	PMID:21073867\|ZFIN:ZDB-PUB-101122-3
Biological Process	GO:0016477	cell migration	L1CAM	IDA		Human	PMID:22973895
Biological Process	GO:0007166	cell surface receptor signaling pathway	L1cam	IDA		Mouse	PMID:7613634
Biological Process	GO:0033631	cell-cell adhesion mediated by integrin	L1cam	IMP		Mouse	PMID:8557754
Biological Process	GO:0007160	cell-matrix adhesion	L1CAM	IDA		Human	PMID:22973895
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	L1cam	IEP		Rat	PMID:1377284\|RGD:11570520
Biological Process	GO:0071361	cellular response to ethanol	L1cam	IEP		Rat	PMID:21884525\|RGD:6483018
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	L1cam	IEP		Rat	PMID:3511068\|RGD:11570521
Biological Process	GO:0097069	cellular response to thyroxine stimulus	L1cam	IEP		Rat	PMID:11085884\|RGD:11570514
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	L1cam	IEP		Rat	PMID:16686695\|RGD:6483452
Biological Process	GO:0071542	dopaminergic neuron differentiation	L1cam	IEP		Rat	PMID:1350253\|RGD:11570519
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	L1cam	IMP		Mouse	PMID:8557754
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	L1cam	IMP		Mouse	PMID:7669058
Biological Process	GO:0034109	homotypic cell-cell adhesion	L1cam	IMP		Mouse	PMID:7613634
Biological Process	GO:0007159	leukocyte cell-cell adhesion	L1cam	IMP		Mouse	PMID:8117278
Biological Process	GO:0007159	leukocyte cell-cell adhesion	L1cam	IMP		Mouse	PMID:8557754
Biological Process	GO:0050804	modulation of chemical synaptic transmission	L1cam	EXP		Rat	PMID:7997264\|RGD:13702438
Biological Process	GO:0050804	modulation of chemical synaptic transmission	L1cam	IDA		Rat	PMID:7997264\|RGD:13702438
Biological Process	GO:0007399	nervous system development	l1camb	IMP	ZFIN:ZDB-MRPHLNO-190724-3	Zfish	PMID:30842511
Biological Process	GO:0007399	nervous system development	l1camb	IMP	ZFIN:ZDB-MRPHLNO-190724-2	Zfish	PMID:30842511
Biological Process	GO:0030182	neuron differentiation	L1cam	IEP		Rat	PMID:24841827\|RGD:11570515
Biological Process	GO:0031175	neuron projection development	L1CAM	IDA		Human	PMID:22973895
Biological Process	GO:0031175	neuron projection development	L1cam	IMP	MGI:MGI:2181735	Mouse	PMID:11283023
Biological Process	GO:0031175	neuron projection development	L1cam	IDA		Mouse	PMID:11283023
Biological Process	GO:0045773	positive regulation of axon extension	L1cam	IMP		Rat	PMID:18519736\|RGD:10054086
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	L1cam	IDA		Mouse	PMID:7613634
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	L1cam	IMP		Mouse	PMID:7669058
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	L1cam	IDA		Rat	PMID:8636223\|RGD:11570518
Biological Process	GO:0010628	positive regulation of gene expression	l1camb	IMP		Zfish	PMID:21073867\|ZFIN:ZDB-PUB-101122-3
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	L1cam	IDA		Rat	PMID:16478533\|RGD:11570403
Biological Process	GO:0014823	response to activity	L1cam	IEP		Rat	PMID:12499861\|RGD:11570528
Biological Process	GO:0097066	response to thyroid hormone	L1cam	IEP		Rat	PMID:11085884\|RGD:11570514
Biological Process	GO:0050808	synapse organization	L1CAM	IDA		Human	PMID:24155914

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.