Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LAPTM5
  • Mouse genes Laptm5
  • Rat genes Laptm5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Laptm5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Laptm5	IPI	UniProtKB:Q60769	Mouse	MGI:MGI:6391873|PMID:22733818
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q9GZU1	Human	PMID:21224396
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q5T700	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q96F81	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:P00387	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:P02724	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:P23763-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:P30519	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q5QGT7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q8N6F1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q8N743	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q8WVX3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q9H0U6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q9NS64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q9NVV5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q9Y385	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LAPTM5	IPI	UniProtKB:Q9Y5U4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Laptm5	IPI	UniProtKB:P24161	Mouse	MGI:MGI:3803048|PMID:18619870
Molecular Function	GO:0140311	protein sequestering activity	Laptm5	IMP		Mouse	MGI:MGI:3803048|PMID:18619870
Molecular Function	GO:0031625	ubiquitin protein ligase binding	LAPTM5	IPI	UniProtKB:P46934	Human	PMID:17116753
Molecular Function	GO:0031625	ubiquitin protein ligase binding	LAPTM5	IPI	UniProtKB:Q96J02	Human	PMID:22009753
Molecular Function	GO:0140036	ubiquitin-dependent protein binding	LAPTM5	IMP		Human	PMID:17116753
Cellular Component	GO:0031410	cytoplasmic vesicle	LAPTM5	IDA		Human	PMID:22009753
Cellular Component	GO:0005765	lysosomal membrane	LAPTM5	IDA		Human	PMID:17116753
Cellular Component	GO:0005764	lysosome	LAPTM5	IDA		Human	PMID:22096579
Cellular Component	GO:0005764	lysosome	LAPTM5	IDA		Human	PMID:8661146
Cellular Component	GO:0005764	lysosome	Laptm5	IDA		Mouse	MGI:MGI:6478861|PMID:24638062
Cellular Component	GO:0005764	lysosome	Laptm5	IDA		Mouse	MGI:MGI:3803048|PMID:18619870
Cellular Component	GO:0005764	lysosome	Laptm5	IDA		Mouse	MGI:MGI:5444793|PMID:22949502
Cellular Component	GO:0005764	lysosome	Laptm5	IDA		Mouse	MGI:MGI:4460047|PMID:20519653
Cellular Component	GO:0005764	lysosome	Laptm5	IDA		Mouse	MGI:MGI:6391873|PMID:22733818
Cellular Component	GO:0005764	lysosome	Laptm5	IDA		Rat	PMID:11295227|RGD:633121
Cellular Component	GO:0005764	lysosome	Laptm5	IDA		Rat	PMID:8661146|RGD:39458012
Cellular Component	GO:0048471	perinuclear region of cytoplasm	LAPTM5	IMP		Human	PMID:28464033
Cellular Component	GO:0005886	plasma membrane	LAPTM5	IDA		Human	PMID:8661146
Cellular Component	GO:0032991	protein-containing complex	LAPTM5	IDA		Human	PMID:17116753
Cellular Component	GO:0030133	transport vesicle	LAPTM5	IDA		Human	PMID:19787053
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	LAPTM5	IMP		Human	PMID:28464033
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Laptm5	IEP		Mouse	PMID:20439489
Biological Process	GO:0002357	defense response to tumor cell	LAPTM5	IDA		Human	PMID:19787053
Biological Process	GO:0090160	Golgi to lysosome transport	Laptm5	IDA		Mouse	MGI:MGI:6478861|PMID:24638062
Biological Process	GO:0012502	induction of programmed cell death	LAPTM5	IDA		Human	PMID:19787053
Biological Process	GO:0006886	intracellular protein transport	Laptm5	IMP		Mouse	MGI:MGI:6453224|PMID:31545469
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	Laptm5	IMP		Mouse	MGI:MGI:3803048|PMID:18619870
Biological Process	GO:1904093	negative regulation of autophagic cell death	LAPTM5	IDA		Human	PMID:19787053
Biological Process	GO:0050869	negative regulation of B cell activation	Laptm5	IMP		Mouse	MGI:MGI:4460047|PMID:20519653
Biological Process	GO:0032703	negative regulation of interleukin-2 production	Laptm5	IMP		Mouse	MGI:MGI:3803048|PMID:18619870
Biological Process	GO:0140646	negative regulation of pre-B cell receptor expression	Laptm5	IMP		Mouse	MGI:MGI:5444793|PMID:22949502
Biological Process	GO:0050868	negative regulation of T cell activation	Laptm5	IMP		Mouse	MGI:MGI:3803048|PMID:18619870
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	Laptm5	IMP		Mouse	MGI:MGI:3803048|PMID:18619870
Biological Process	GO:0032689	negative regulation of type II interferon production	Laptm5	IMP		Mouse	MGI:MGI:3803048|PMID:18619870
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	Laptm5	IMP		Mouse	MGI:MGI:6391873|PMID:22733818
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Laptm5	IMP		Mouse	MGI:MGI:6391873|PMID:22733818
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Laptm5	IMP		Mouse	MGI:MGI:6391873|PMID:22733818
Biological Process	GO:0097214	positive regulation of lysosomal membrane permeability	LAPTM5	IDA		Human	PMID:19787053
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Laptm5	IMP		Mouse	MGI:MGI:6391873|PMID:22733818
Biological Process	GO:0043410	positive regulation of MAPK cascade	Laptm5	IMP		Mouse	MGI:MGI:6391873|PMID:22733818
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Laptm5	IMP		Mouse	MGI:MGI:6391873|PMID:22733818
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Laptm5	IMP		Mouse	MGI:MGI:6391873|PMID:22733818
Biological Process	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	Laptm5	IMP		Mouse	MGI:MGI:5444793|PMID:22949502
Biological Process	GO:2000646	positive regulation of receptor catabolic process	Laptm5	IMP		Mouse	MGI:MGI:4460047|PMID:20519653
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	Laptm5	IMP		Mouse	MGI:MGI:6391873|PMID:22733818
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Laptm5	IDA		Mouse	MGI:MGI:6478861|PMID:24638062
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Laptm5	IMP		Mouse	MGI:MGI:3803048|PMID:18619870
Biological Process	GO:0061462	protein localization to lysosome	Laptm5	IMP		Mouse	MGI:MGI:5444793|PMID:22949502
Biological Process	GO:0006622	protein targeting to lysosome	Laptm5	IDA		Mouse	MGI:MGI:3803048|PMID:18619870

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern