Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LARGE1
  • Mouse genes Large1
  • Rat genes Large1
  • Zfish genes large1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Large1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015020	glucuronosyltransferase activity	LARGE1	IDA		Human	PMID:22223806
Molecular Function	GO:0015020	glucuronosyltransferase activity	LARGE1	IDA		Human	PMID:25279697
Molecular Function	GO:0015020	glucuronosyltransferase activity	LARGE1	IDA		Human	PMID:25279699
Molecular Function	GO:0015020	glucuronosyltransferase activity	Large1	IDA		Mouse	MGI:MGI:6810695|PMID:23723439
Molecular Function	GO:0015020	glucuronosyltransferase activity	Large1	IDA		Mouse	MGI:MGI:5607212|PMID:23135544
Molecular Function	GO:0015020	glucuronosyltransferase activity	Large1	IDA		Mouse	MGI:MGI:5607213|PMID:23125099
Molecular Function	GO:0015020	glucuronosyltransferase activity	Large1	IDA		Mouse	PMID:25138275
Molecular Function	GO:0016757	glycosyltransferase activity	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:25138275
Molecular Function	GO:0016758	hexosyltransferase activity	LARGE1	IDA		Human	PMID:32975514
Molecular Function	GO:0016758	hexosyltransferase activity	Large1	IDA		Mouse	MGI:MGI:6508185|PMID:32975514
Molecular Function	GO:0030145	manganese ion binding	LARGE1	IDA		Human	PMID:25138275
Molecular Function	GO:0005515	protein binding	Large1	IPI	UniProtKB:Q28685	Mouse	MGI:MGI:5284802|PMID:15210115
Molecular Function	GO:0042285	xylosyltransferase activity	LARGE1	IDA		Human	PMID:22223806
Molecular Function	GO:0042285	xylosyltransferase activity	LARGE1	IDA		Human	PMID:25279697
Molecular Function	GO:0042285	xylosyltransferase activity	Large1	IDA		Mouse	MGI:MGI:5607212|PMID:23135544
Molecular Function	GO:0042285	xylosyltransferase activity	Large1	IDA		Mouse	MGI:MGI:5607213|PMID:23125099
Molecular Function	GO:0042285	xylosyltransferase activity	Large1	IDA		Mouse	PMID:25138275
Cellular Component	GO:0005794	Golgi apparatus	LARGE1	IDA		Human	PMID:25279699
Cellular Component	GO:0000139	Golgi membrane	Large1	IDA		Mouse	MGI:MGI:6810695|PMID:23723439
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Large1	IDA		Mouse	PMID:25138275
Cellular Component	GO:0031594	neuromuscular junction	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19346129
Cellular Component	GO:0005886	plasma membrane	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:15389724
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19346129
Biological Process	GO:0048708	astrocyte differentiation	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0048708	astrocyte differentiation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16111892
Biological Process	GO:0071711	basement membrane organization	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:12140558
Biological Process	GO:0071711	basement membrane organization	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21970971
Biological Process	GO:0001568	blood vessel development	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0001568	blood vessel development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16111892
Biological Process	GO:0060348	bone development	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0055013	cardiac muscle cell development	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0048738	cardiac muscle tissue development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21628317
Biological Process	GO:0007268	chemical synaptic transmission	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0007268	chemical synaptic transmission	Large1	IDA		Mouse	PMID:23222475
Biological Process	GO:0007268	chemical synaptic transmission	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:23222475
Biological Process	GO:0061448	connective tissue development	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0007010	cytoskeleton organization	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:15389724
Biological Process	GO:0021542	dentate gyrus development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21970971
Biological Process	GO:0008340	determination of adult lifespan	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0008340	determination of adult lifespan	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0010467	gene expression	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:15389724
Biological Process	GO:0010467	gene expression	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:17803675
Biological Process	GO:0010467	gene expression	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19017726
Biological Process	GO:0010467	gene expression	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19346129
Biological Process	GO:0010467	gene expression	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21129441
Biological Process	GO:0010467	gene expression	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:22270369
Biological Process	GO:0010467	gene expression	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0010467	gene expression	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:24753587
Biological Process	GO:0010467	gene expression	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0009101	glycoprotein biosynthetic process	Large1	IDA		Mouse	PMID:15184894
Biological Process	GO:0009101	glycoprotein biosynthetic process	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:15184894
Biological Process	GO:0009100	glycoprotein metabolic process	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:12140558
Biological Process	GO:0007507	heart development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21628317
Biological Process	GO:0060173	limb development	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0035264	multicellular organism growth	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0035264	multicellular organism growth	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0032504	multicellular organism reproduction	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0046716	muscle cell cellular homeostasis	Large1	IMP		Mouse	MGI:MGI:2135469|PMID:11381262
Biological Process	GO:0007517	muscle organ development	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0014902	myotube differentiation	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0021675	nerve development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19346129
Biological Process	GO:0007528	neuromuscular junction development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19346129
Biological Process	GO:0007528	neuromuscular junction development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:23222475
Biological Process	GO:0007528	neuromuscular junction development	Large1	IDA		Mouse	PMID:23222475
Biological Process	GO:0050884	neuromuscular process controlling posture	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0007274	neuromuscular synaptic transmission	Large1	IDA		Mouse	PMID:23222475
Biological Process	GO:0007274	neuromuscular synaptic transmission	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:23222475
Biological Process	GO:0001764	neuron migration	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:12140558
Biological Process	GO:0001764	neuron migration	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16819976
Biological Process	GO:0001764	neuron migration	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16956587
Biological Process	GO:0007009	plasma membrane organization	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:15389724
Biological Process	GO:0007009	plasma membrane organization	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21628317
Biological Process	GO:0035129	post-embryonic hindlimb morphogenesis	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0043687	post-translational protein modification	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:12140558
Biological Process	GO:0071805	potassium ion transmembrane transport	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:17803675
Biological Process	GO:0021740	principal sensory nucleus of trigeminal nerve development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16819976
Biological Process	GO:0021740	principal sensory nucleus of trigeminal nerve development	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16956587
Biological Process	GO:0006486	protein glycosylation	LARGE1	IMP		Human	PMID:32975514
Biological Process	GO:0006486	protein glycosylation	Large1	IMP		Mouse	MGI:MGI:6508185|PMID:32975514
Biological Process	GO:0006486	protein glycosylation	Large1	IDA		Mouse	PMID:15788414
Biological Process	GO:0006486	protein glycosylation	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0006486	protein glycosylation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16111892
Biological Process	GO:0006486	protein glycosylation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21129441
Biological Process	GO:0006486	protein glycosylation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19797173
Biological Process	GO:0006486	protein glycosylation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21628317
Biological Process	GO:0006486	protein glycosylation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:23222475
Biological Process	GO:0006486	protein glycosylation	Large1	IDA		Mouse	PMID:23222475
Biological Process	GO:0006486	protein glycosylation	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0006486	protein glycosylation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:25976249
Biological Process	GO:0008104	protein localization	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:17803675
Biological Process	GO:0072657	protein localization to membrane	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:17803675
Biological Process	GO:0036211	protein modification process	Large1	IDA		Mouse	PMID:15788414
Biological Process	GO:0036211	protein modification process	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:20044576
Biological Process	GO:0036211	protein modification process	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:22270369
Biological Process	GO:0006493	protein O-linked glycosylation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19346129
Biological Process	GO:0035269	protein O-linked mannosylation	LARGE1	IDA		Human	PMID:22223806
Biological Process	GO:0035269	protein O-linked mannosylation	LARGE1	IDA		Human	PMID:25138275
Biological Process	GO:0035269	protein O-linked mannosylation	LARGE1	IDA		Human	PMID:25279697
Biological Process	GO:0035269	protein O-linked mannosylation	LARGE1	IDA		Human	PMID:25279699
Biological Process	GO:0035269	protein O-linked mannosylation	Large1	IDA		Mouse	MGI:MGI:5607212|PMID:23135544
Biological Process	GO:0035269	protein O-linked mannosylation	Large1	IDA		Mouse	MGI:MGI:5607213|PMID:23125099
Biological Process	GO:0006468	protein phosphorylation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:20044576
Biological Process	GO:0065003	protein-containing complex assembly	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:15389724
Biological Process	GO:0065003	protein-containing complex assembly	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19346129
Biological Process	GO:0150103	reactive gliosis	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21970971
Biological Process	GO:0043549	regulation of kinase activity	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:23222475
Biological Process	GO:0043549	regulation of kinase activity	Large1	IDA		Mouse	PMID:23222475
Biological Process	GO:0043393	regulation of protein binding	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:12140558
Biological Process	GO:0043393	regulation of protein binding	Large1	IDA		Mouse	PMID:19017726
Biological Process	GO:0043393	regulation of protein binding	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19017726
Biological Process	GO:0043393	regulation of protein binding	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:20044576
Biological Process	GO:0043393	regulation of protein binding	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21129441
Biological Process	GO:0043393	regulation of protein binding	Large1	IDA		Mouse	PMID:21129441
Biological Process	GO:0043393	regulation of protein binding	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21628317
Biological Process	GO:0048167	regulation of synaptic plasticity	Large1	IMP		Mouse	PMID:24753587
Biological Process	GO:0009612	response to mechanical stimulus	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21628317
Biological Process	GO:0060041	retina development in camera-type eye	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16111892
Biological Process	GO:0060041	retina development in camera-type eye	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0010842	retina layer formation	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16111892
Biological Process	GO:0010842	retina layer formation	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16111892
Biological Process	GO:0048741	skeletal muscle fiber development	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0060538	skeletal muscle organ development	Large1	IDA		Mouse	MGI:MGI:5547845|PMID:24132234
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Large1	IDA		Mouse	MGI:MGI:5547845|PMID:24132234
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Large1	IDA		Mouse	PMID:24722207
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:25976249
Biological Process	GO:0055002	striated muscle cell development	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:23222475
Biological Process	GO:0055002	striated muscle cell development	Large1	IDA		Mouse	PMID:23222475
Biological Process	GO:0055002	striated muscle cell development	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0006941	striated muscle contraction	Large1	IDA		Mouse	PMID:23222475
Biological Process	GO:0006941	striated muscle contraction	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:23222475
Biological Process	GO:0006941	striated muscle contraction	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0050808	synapse organization	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:16111892
Biological Process	GO:0050808	synapse organization	Large1	IMP	MGI:MGI:3510641	Mouse	PMID:16111892
Biological Process	GO:0051124	synaptic assembly at neuromuscular junction	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:19346129
Biological Process	GO:0055085	transmembrane transport	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:21628317
Biological Process	GO:0090659	walking behavior	Large1	IGI	MGI:MGI:94909	Mouse	PMID:23798567
Biological Process	GO:0006833	water transport	Large1	IMP	MGI:MGI:1856965	Mouse	PMID:17803675

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern