Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LATS1
  • Mouse genes Lats1
  • Rat genes Lats1
  • Zfish genes lats1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lats1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	LATS1	IDA		Human	PMID:10518011
Molecular Function	GO:0000287	magnesium ion binding	LATS1	IDA		Human	PMID:10518011
Molecular Function	GO:0030331	nuclear estrogen receptor binding	LATS1	IPI	UniProtKB:P03372	Human	PMID:28068668
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q15942	Human	PMID:10831611
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P53667	Human	PMID:15220930
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P46937	Human	PMID:18158288
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q7L9L4	Human	PMID:19739119
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q9H8S9	Human	PMID:19739119
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:O60285	Human	PMID:19927127
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:A6NIX2	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q96IF1	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q9UGP4	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q9GZV5	Human	PMID:20412773
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q9GZV5	Human	PMID:22078877
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P46937	Human	PMID:22863277
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P35240	Human	PMID:24012335
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P46937	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q7L9L4	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q9H8S9	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q15831	Human	PMID:24362629
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P46937	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q7L9L4	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P46662	Human	PMID:25026211
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q9Y4B6	Human	PMID:25026211
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P06493	Human	PMID:25218637
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P24941	Human	PMID:25218637
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P46937	Human	PMID:25283809
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:O43255	Human	PMID:25438054
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P46937	Human	PMID:25751139
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P03372	Human	PMID:28068668
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q13188	Human	PMID:28087714
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q14160	Human	PMID:28169360
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q7L9L4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:Q9UPX8	Human	PMID:32661924
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	LATS1	IPI	UniProtKB:P06493	Human	PMID:9988268
Molecular Function	GO:0005515	protein binding	Lats1	IPI	UniProtKB:Q9EPK5	Mouse	MGI:MGI:4939579|PMID:21145499
Molecular Function	GO:0019901	protein kinase binding	LATS1	IPI	UniProtKB:O60285	Human	PMID:19927127
Molecular Function	GO:0019901	protein kinase binding	LATS1	IPI	UniProtKB:Q9H093	Human	PMID:19927127
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LATS1	IDA		Human	PMID:10518011
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LATS1	IDA		Human	PMID:20412773
Cellular Component	GO:0000922	spindle pole	LATS1	IDA		Human	PMID:10518011
Biological Process	GO:0030509	BMP signaling pathway	lats1	IMP	ZFIN:ZDB-GENO-190226-1	Zfish	PMID:29809141
Biological Process	GO:0030509	BMP signaling pathway	lats1	IGI	ZFIN:ZDB-GENE-050119-6	Zfish	PMID:29809141
Biological Process	GO:0060027	convergent extension involved in gastrulation	lats1	IMP	ZFIN:ZDB-MRPHLNO-100415-2	Zfish	PMID:19842174
Biological Process	GO:0060027	convergent extension involved in gastrulation	lats1	IGI	ZFIN:ZDB-MRPHLNO-100415-2,ZFIN:ZDB-MRPHLNO-100415-4	Zfish	PMID:19842174
Biological Process	GO:0060027	convergent extension involved in gastrulation	lats1	IMP	ZFIN:ZDB-MRPHLNO-100415-1	Zfish	PMID:19842174
Biological Process	GO:0051220	cytoplasmic sequestering of protein	LATS1	IMP		Human	PMID:20412773
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	LATS1	IDA		Human	PMID:15122335
Biological Process	GO:0035329	hippo signaling	LATS1	IDA		Human	PMID:20412773
Biological Process	GO:0035329	hippo signaling	Lats1	IGI	MGI:MGI:103262	Mouse	PMID:18369314
Biological Process	GO:0035329	hippo signaling	Lats1	IGI	MGI:MGI:1927144	Mouse	PMID:18369314
Biological Process	GO:0035329	hippo signaling	Lats1	IGI	MGI:MGI:1929004	Mouse	PMID:18369314
Biological Process	GO:0009755	hormone-mediated signaling pathway	Lats1	IDA		Mouse	MGI:MGI:1329731|PMID:9988269
Biological Process	GO:0001827	inner cell mass cell fate commitment	Lats1	IGI	MGI:MGI:1354386	Mouse	PMID:23824537
Biological Process	GO:0001828	inner cell mass cellular morphogenesis	Lats1	IGI	MGI:MGI:1354386	Mouse	PMID:23824537
Biological Process	GO:0030216	keratinocyte differentiation	Lats1	IGI	MGI:MGI:103262	Mouse	PMID:18369314
Biological Process	GO:0030216	keratinocyte differentiation	Lats1	IGI	MGI:MGI:1927144	Mouse	PMID:18369314
Biological Process	GO:0030216	keratinocyte differentiation	Lats1	IGI	MGI:MGI:1929004	Mouse	PMID:18369314
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	LATS1	IMP		Human	PMID:28068668
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	LATS1	IMP		Human	PMID:20412773
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	LATS1	IDA		Human	PMID:9988268
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	Lats1	IMP		Mouse	MGI:MGI:4939579|PMID:21145499
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	LATS1	IDA		Human	PMID:20412773
Biological Process	GO:0008104	protein localization	Lats1	IGI	MGI:MGI:1354386	Mouse	PMID:19289085
Biological Process	GO:0006468	protein phosphorylation	LATS1	IDA		Human	PMID:10518011
Biological Process	GO:0030833	regulation of actin filament polymerization	LATS1	IDA		Human	PMID:15220930
Biological Process	GO:0033146	regulation of intracellular estrogen receptor signaling pathway	LATS1	IMP		Human	PMID:28068668
Biological Process	GO:0043254	regulation of protein-containing complex assembly	LATS1	IMP		Human	PMID:20412773
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Lats1	IMP		Mouse	MGI:MGI:4939579|PMID:21145499
Biological Process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	LATS1	IMP		Human	PMID:28068668
Biological Process	GO:0000819	sister chromatid segregation	LATS1	IDA		Human	PMID:15122335

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern