Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LATS2
  • Mouse genes Lats2
  • Rat genes Lats2
  • Zfish genes lats2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lats2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	LATS2	IDA		Human	PMID:10871863
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q96IF1	Human	PMID:16413547
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:P46937	Human	PMID:18158288
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q7L9L4	Human	PMID:19739119
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q9H8S9	Human	PMID:19739119
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:A6NIX2	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q96IF1	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q9UGP4	Human	PMID:20303269
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q7L9L4	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q9H8S9	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q6AWC2	Human	PMID:24682284
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q8IX03	Human	PMID:24682284
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q9ULE0	Human	PMID:24682284
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q9Y4B6	Human	PMID:25026211
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:O43255	Human	PMID:25438054
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q13643	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q7L9L4	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:O14578	Human	PMID:30865227
Molecular Function	GO:0005515	protein binding	LATS2	IPI	UniProtKB:Q7L9L4	Human	PMID:32707033
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LATS2	IDA		Human	PMID:10871863
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LATS2	IDA		Human	PMID:30865227
Cellular Component	GO:0034451	centriolar satellite	LATS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	LATS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	LATS2	IDA		Human	PMID:30865227
Cellular Component	GO:0005634	nucleus	LATS2	IDA		Human	PMID:10673337
Cellular Component	GO:0000922	spindle pole	LATS2	IDA		Human	PMID:12853976
Cellular Component	GO:0000922	spindle pole	Lats2	IDA		Mouse	MGI:MGI:3056218|PMID:15343267
Biological Process	GO:0030509	BMP signaling pathway	lats2	IGI	ZFIN:ZDB-GENE-050523-2	Zfish	PMID:29809141
Biological Process	GO:0030509	BMP signaling pathway	lats2	IMP	ZFIN:ZDB-GENO-190226-1	Zfish	PMID:29809141
Biological Process	GO:0060070	canonical Wnt signaling pathway	Lats2	IGI	MGI:MGI:88276	Mouse	PMID:21512031
Biological Process	GO:0060027	convergent extension involved in gastrulation	lats2	IMP	ZFIN:ZDB-MRPHLNO-100415-3	Zfish	PMID:19842174
Biological Process	GO:0060027	convergent extension involved in gastrulation	lats2	IGI	ZFIN:ZDB-MRPHLNO-100415-2,ZFIN:ZDB-MRPHLNO-100415-4	Zfish	PMID:19842174
Biological Process	GO:0060027	convergent extension involved in gastrulation	lats2	IMP	ZFIN:ZDB-MRPHLNO-100415-4	Zfish	PMID:19842174
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	LATS2	IDA		Human	PMID:12853976
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	Lats2	IDA		Mouse	MGI:MGI:3056218|PMID:15343267
Biological Process	GO:0035329	hippo signaling	LATS2	IDA		Human	PMID:20412773
Biological Process	GO:0035329	hippo signaling	Lats2	IGI	MGI:MGI:103262	Mouse	PMID:18369314
Biological Process	GO:0035329	hippo signaling	Lats2	IGI	MGI:MGI:1927144	Mouse	PMID:18369314
Biological Process	GO:0035329	hippo signaling	Lats2	IGI	MGI:MGI:1929004	Mouse	PMID:18369314
Biological Process	GO:0009755	hormone-mediated signaling pathway	LATS2	IDA		Human	PMID:15131260
Biological Process	GO:0001827	inner cell mass cell fate commitment	Lats2	IGI	MGI:MGI:1333883	Mouse	PMID:23824537
Biological Process	GO:0001828	inner cell mass cellular morphogenesis	Lats2	IGI	MGI:MGI:1333883	Mouse	PMID:23824537
Biological Process	GO:0035556	intracellular signal transduction	LATS2	IDA		Human	PMID:10871863
Biological Process	GO:0030216	keratinocyte differentiation	Lats2	IGI	MGI:MGI:103262	Mouse	PMID:18369314
Biological Process	GO:0030216	keratinocyte differentiation	Lats2	IGI	MGI:MGI:1927144	Mouse	PMID:18369314
Biological Process	GO:0030216	keratinocyte differentiation	Lats2	IGI	MGI:MGI:1929004	Mouse	PMID:18369314
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	LATS2	IMP		Human	PMID:20412773
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Lats2	IGI	MGI:MGI:88276	Mouse	PMID:21512031
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	LATS2	IDA		Human	PMID:12853976
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	Lats2	IMP		Mouse	MGI:MGI:4939579|PMID:21145499
Biological Process	GO:0008104	protein localization	Lats2	IDA		Mouse	PMID:19289085
Biological Process	GO:0008104	protein localization	Lats2	IGI	MGI:MGI:1333883	Mouse	PMID:19289085
Biological Process	GO:0006468	protein phosphorylation	LATS2	IDA		Human	PMID:10871863
Biological Process	GO:0006468	protein phosphorylation	Lats2	IDA		Mouse	PMID:19289085
Biological Process	GO:0046620	regulation of organ growth	Lats2	IMP	MGI:MGI:2654594,MGI:MGI:4430538	Mouse	PMID:21512031
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Lats2	IMP		Mouse	MGI:MGI:4939579|PMID:21145499

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern