Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LAX1
  • Mouse genes Lax1
  • Rat genes Lax1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lax1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LAX1	IPI	UniProtKB:O75791	Human	PMID:12359715
Molecular Function	GO:0005515	protein binding	LAX1	IPI	UniProtKB:P43403	Human	PMID:12359715
Molecular Function	GO:0005515	protein binding	LAX1	IPI	UniProtKB:P62993	Human	PMID:12359715
Molecular Function	GO:0005515	protein binding	LAX1	IPI	UniProtKB:Q14451	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LAX1	IPI	UniProtKB:Q96FJ0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LAX1	IPI	UniProtKB:Q14451	Human	PMID:31515488
Molecular Function	GO:0019901	protein kinase binding	LAX1	IDA		Human	PMID:12359715
Molecular Function	GO:0042169	SH2 domain binding	LAX1	IDA		Human	PMID:12359715
Cellular Component	GO:0005829	cytosol	LAX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	LAX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	LAX1	IDA		Human	PMID:12359715
Cellular Component	GO:0016020	membrane	LAX1	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	LAX1	IDA		Human	GO_REF:0000052
Biological Process	GO:0050851	antigen receptor-mediated signaling pathway	Lax1	IMP	MGI:MGI:3579135	Mouse	PMID:15843560
Biological Process	GO:0042113	B cell activation	LAX1	IDA		Human	PMID:12359715
Biological Process	GO:0006955	immune response	LAX1	IDA		Human	PMID:12359715
Biological Process	GO:0002377	immunoglobulin production	Lax1	IMP	MGI:MGI:3579135	Mouse	PMID:15843560
Biological Process	GO:0035556	intracellular signal transduction	LAX1	IDA		Human	PMID:12359715
Biological Process	GO:0046649	lymphocyte activation	Lax1	IMP	MGI:MGI:3579135	Mouse	PMID:15843560
Biological Process	GO:0043407	negative regulation of MAP kinase activity	LAX1	IMP		Human	PMID:12359715
Biological Process	GO:0050868	negative regulation of T cell activation	LAX1	IDA		Human	PMID:12359715

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern