Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LBP
  • Mouse genes Lbp
  • Rat genes Lbp
  • Zfish genes bpifcl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lbp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015026	coreceptor activity	LBP	IPI	UniProtKB:Q9R3N6	Human	PMID:15294986
Molecular Function	GO:0071723	lipopeptide binding	LBP	IDA		Human	PMID:15294986
Molecular Function	GO:0001530	lipopolysaccharide binding	LBP	IDA		Human	PMID:12594207
Molecular Function	GO:0001530	lipopolysaccharide binding	LBP	IMP		Human	PMID:24120359
Molecular Function	GO:0001530	lipopolysaccharide binding	Lbp	IDA		Mouse	PMID:11079463
Molecular Function	GO:0001530	lipopolysaccharide binding	Lbp	IDA		Rat	PMID:22580761|RGD:9685189
Molecular Function	GO:0070891	lipoteichoic acid binding	LBP	IDA		Human	PMID:12594207
Molecular Function	GO:0005515	protein binding	LBP	IPI	UniProtKB:Q13162	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	LBP	IPI	UniProtKB:P23560-2	Human	PMID:32814053
Molecular Function	GO:0005102	signaling receptor binding	Lbp	IDA		Mouse	MGI:MGI:1097829|PMID:9338787
Cellular Component	GO:0009986	cell surface	LBP	IDA		Human	PMID:11528597
Cellular Component	GO:0009986	cell surface	Lbp	IDA		Mouse	MGI:MGI:3807766|PMID:12932360
Cellular Component	GO:0070062	extracellular exosome	LBP	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	LBP	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	LBP	IDA		Human	PMID:11528597
Cellular Component	GO:0005615	extracellular space	LBP	IDA		Human	PMID:2402637
Cellular Component	GO:0005615	extracellular space	LBP	IDA		Human	PMID:24120359
Cellular Component	GO:0005615	extracellular space	Lbp	IDA		Mouse	MGI:MGI:1097829|PMID:9338787
Cellular Component	GO:0005615	extracellular space	Lbp	IDA		Mouse	PMID:12055258
Cellular Component	GO:0005615	extracellular space	Lbp	IDA		Rat	PMID:22580761|RGD:9685189
Biological Process	GO:0006953	acute-phase response	LBP	IEP		Human	PMID:12932360
Biological Process	GO:0006953	acute-phase response	Lbp	IMP		Mouse	MGI:MGI:3807766|PMID:12932360
Biological Process	GO:0002752	cell surface pattern recognition receptor signaling pathway	LBP	IDA		Human	PMID:15294986
Biological Process	GO:0071222	cellular response to lipopolysaccharide	LBP	IDA		Human	PMID:12594207
Biological Process	GO:0071222	cellular response to lipopolysaccharide	LBP	IMP		Human	PMID:24120359
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Lbp	IMP		Mouse	MGI:MGI:5645195|PMID:24380872
Biological Process	GO:0071223	cellular response to lipoteichoic acid	LBP	IDA		Human	PMID:12594207
Biological Process	GO:0050829	defense response to Gram-negative bacterium	LBP	IDA		Human	PMID:11528597
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Lbp	IMP		Mouse	MGI:MGI:1097829|PMID:9338787
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Lbp	IMP	MGI:MGI:1857975	Mouse	PMID:12055258
Biological Process	GO:0050830	defense response to Gram-positive bacterium	LBP	IDA		Human	PMID:12932360
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Lbp	IMP		Mouse	MGI:MGI:3807766|PMID:12932360
Biological Process	GO:0032490	detection of molecule of bacterial origin	LBP	IDA		Human	PMID:11528597
Biological Process	GO:0045087	innate immune response	Lbp	IMP		Mouse	MGI:MGI:3807766|PMID:12932360
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	Lbp	IMP	MGI:MGI:1857975	Mouse	PMID:12055258
Biological Process	GO:0015920	lipopolysaccharide transport	LBP	IDA		Human	PMID:8985160
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	LBP	IDA		Human	PMID:11739189
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	LBP	IDA		Human	PMID:8409400
Biological Process	GO:0001889	liver development	Lbp	IEP		Rat	PMID:20978830|RGD:9685195
Biological Process	GO:0002281	macrophage activation involved in immune response	LBP	IMP		Human	PMID:24120359
Biological Process	GO:0002281	macrophage activation involved in immune response	Lbp	IDA		Mouse	MGI:MGI:3807766|PMID:12932360
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	LBP	IDA		Human	PMID:11739189
Biological Process	GO:0030593	neutrophil chemotaxis	Lbp	IMP	MGI:MGI:1857975	Mouse	PMID:12055258
Biological Process	GO:0032722	positive regulation of chemokine production	Lbp	IMP	MGI:MGI:1857975	Mouse	PMID:12055258
Biological Process	GO:0032755	positive regulation of interleukin-6 production	LBP	IDA		Human	PMID:8409400
Biological Process	GO:0032757	positive regulation of interleukin-8 production	LBP	IDA		Human	PMID:8409400
Biological Process	GO:0043032	positive regulation of macrophage activation	LBP	IDA		Human	PMID:8409400
Biological Process	GO:0043032	positive regulation of macrophage activation	Lbp	IDA		Rat	PMID:10733550|RGD:9685188
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Lbp	IMP	MGI:MGI:1857975	Mouse	PMID:12055258
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	Lbp	IDA		Rat	PMID:11104656|RGD:9685187
Biological Process	GO:0060265	positive regulation of respiratory burst involved in inflammatory response	Lbp	IMP		Mouse	MGI:MGI:1097829|PMID:9338787
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	LBP	IDA		Human	PMID:11528597
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	LBP	IDA		Human	PMID:12594207
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	LBP	IMP		Human	PMID:24120359
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	LBP	IDA		Human	PMID:8409400
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Lbp	IDA		Mouse	MGI:MGI:3807766|PMID:12932360
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Lbp	IMP		Mouse	MGI:MGI:1097829|PMID:9338787
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Lbp	IMP		Mouse	MGI:MGI:5645195|PMID:24380872
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Lbp	IMP	MGI:MGI:1857975	Mouse	PMID:12055258
Biological Process	GO:0090559	regulation of membrane permeability	Lbp	IMP		Rat	PMID:17446308|RGD:9685199
Biological Process	GO:0032496	response to lipopolysaccharide	LBP	IDA		Human	PMID:11739189
Biological Process	GO:0032496	response to lipopolysaccharide	LBP	IDA		Human	PMID:8409400
Biological Process	GO:0032496	response to lipopolysaccharide	Lbp	IMP		Mouse	MGI:MGI:1097829|PMID:9338787
Biological Process	GO:0032496	response to lipopolysaccharide	Lbp	IMP	MGI:MGI:1857975	Mouse	PMID:12055258
Biological Process	GO:0032640	tumor necrosis factor production	Lbp	IMP	MGI:MGI:1857975	Mouse	PMID:12055258

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern