Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LCAT
  • Mouse genes Lcat
  • Rat genes Lcat
  • Zfish genes lcat
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lcat

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	LCAT	IDA		Human	PMID:8016111
Molecular Function	GO:0034186	apolipoprotein A-I binding	LCAT	IPI	UniProtKB:P02647	Human	PMID:1587806
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	LCAT	IDA		Human	PMID:10559507
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	LCAT	IDA		Human	PMID:26195816
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	LCAT	IDA		Human	PMID:3458198
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	LCAT	IDA		Human	PMID:4335615
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Lcat	IDA		Mouse	PMID:10549415
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Lcat	IDA		Mouse	PMID:9300780
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Lcat	IDA		Mouse	PMID:16245952
Molecular Function	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity	Lcat	IDA		Rat	PMID:9219904|RGD:729077
Molecular Function	GO:0004623	phospholipase A2 activity	Lcat	IDA		Rat	PMID:9219904|RGD:729077
Molecular Function	GO:0047179	platelet-activating factor acetyltransferase activity	LCAT	IDA		Human	PMID:8016111
Molecular Function	GO:0047179	platelet-activating factor acetyltransferase activity	Lcat	IDA		Mouse	MGI:MGI:1339937|PMID:10393212
Molecular Function	GO:0005515	protein binding	LCAT	IPI	UniProtKB:P01023	Human	PMID:11435418
Molecular Function	GO:0005515	protein binding	LCAT	IPI	UniProtKB:P02652	Human	PMID:14967812
Molecular Function	GO:0005515	protein binding	LCAT	IPI	UniProtKB:P02649	Human	PMID:15654758
Molecular Function	GO:0005515	protein binding	LCAT	IPI	UniProtKB:P02647	Human	PMID:1587806
Molecular Function	GO:0005515	protein binding	LCAT	IPI	UniProtKB:P02647	Human	PMID:17676061
Molecular Function	GO:0005515	protein binding	LCAT	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0004771	sterol esterase activity	LCAT	IDA		Human	PMID:8016111
Cellular Component	GO:0070062	extracellular exosome	LCAT	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	LCAT	IDA		Human	PMID:10559507
Cellular Component	GO:0005615	extracellular space	LCAT	IDA		Human	PMID:3458198
Cellular Component	GO:0005615	extracellular space	LCAT	IDA		Human	PMID:4335615
Cellular Component	GO:0005615	extracellular space	LCAT	IDA		Human	PMID:8016111
Cellular Component	GO:0005615	extracellular space	Lcat	IDA		Mouse	PMID:10549415
Cellular Component	GO:0034364	high-density lipoprotein particle	LCAT	IDA		Human	PMID:3104518
Biological Process	GO:0042632	cholesterol homeostasis	LCAT	IDA		Human	PMID:4335615
Biological Process	GO:0008203	cholesterol metabolic process	LCAT	IDA		Human	PMID:10559507
Biological Process	GO:0008203	cholesterol metabolic process	LCAT	IDA		Human	PMID:26195816
Biological Process	GO:0008203	cholesterol metabolic process	LCAT	IDA		Human	PMID:3458198
Biological Process	GO:0008203	cholesterol metabolic process	LCAT	IDA		Human	PMID:4335615
Biological Process	GO:0008203	cholesterol metabolic process	Lcat	IDA		Mouse	PMID:9300780
Biological Process	GO:0008203	cholesterol metabolic process	Lcat	IDA		Rat	PMID:746355|RGD:1581789
Biological Process	GO:0030301	cholesterol transport	LCAT	IDA		Human	PMID:10559507
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	LCAT	IDA		Human	PMID:10722751
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	LCAT	IDA		Human	PMID:12167653
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	LCAT	IDA		Human	PMID:15210842
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	LCAT	IDA		Human	PMID:4335615
Biological Process	GO:0042158	lipoprotein biosynthetic process	Lcat	IDA		Mouse	PMID:16245952
Biological Process	GO:0042157	lipoprotein metabolic process	Lcat	IDA		Rat	PMID:3918579|RGD:1581794
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	LCAT	IDA		Human	PMID:11966470
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	LCAT	IMP		Human	PMID:12354767
Biological Process	GO:0046470	phosphatidylcholine metabolic process	LCAT	IDA		Human	PMID:26195816
Biological Process	GO:0006644	phospholipid metabolic process	LCAT	IDA		Human	PMID:4335615
Biological Process	GO:0090107	regulation of high-density lipoprotein particle assembly	Lcat	IDA		Mouse	MGI:MGI:3848791|PMID:19065001
Biological Process	GO:0046688	response to copper ion	Lcat	IDA		Rat	PMID:7288494|RGD:1581777
Biological Process	GO:0051384	response to glucocorticoid	Lcat	IDA		Rat	PMID:1420288|RGD:1581770
Biological Process	GO:0043691	reverse cholesterol transport	LCAT	IDA		Human	PMID:4335615
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling	LCAT	IDA		Human	PMID:15654758

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern