Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LCK
  • Mouse genes Lck
  • Rat genes Lck
  • Zfish genes lck
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lck

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003823	antigen binding	Lck	IPI	RGD:2297	Rat	PMID:18178839|RGD:2316555
Molecular Function	GO:0051117	ATPase binding	LCK	IPI	UniProtKB:P05023	Human	PMID:15671290
Molecular Function	GO:0042609	CD4 receptor binding	LCK	IPI	UniProtKB:P01730	Human	PMID:7486703
Molecular Function	GO:0042609	CD4 receptor binding	Lck	IPI	UniProtKB:P01730	Mouse	MGI:MGI:5693239|PMID:3262426
Molecular Function	GO:0042610	CD8 receptor binding	LCK	IPI	UniProtKB:P01732	Human	PMID:2470098
Molecular Function	GO:0042802	identical protein binding	LCK	IPI	UniProtKB:P06239	Human	PMID:17118402
Molecular Function	GO:0042802	identical protein binding	LCK	IPI	UniProtKB:P06239	Human	PMID:24463463
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	LCK	IDA		Human	PMID:11606584
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	LCK	IDA		Human	PMID:8681956
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	LCK	IPI	UniProtKB:Q8NEB9	Human	PMID:7504174
Molecular Function	GO:0016004	phospholipase activator activity	LCK	IDA		Human	PMID:11606584
Molecular Function	GO:0043274	phospholipase binding	LCK	IPI	UniProtKB:P16885	Human	PMID:11606584
Molecular Function	GO:0001784	phosphotyrosine residue binding	LCK	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:1990405	protein antigen binding	Lck	IPI	PR:P31041	Mouse	PMID:21245484
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9Y3P8	Human	PMID:10209036
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P43403	Human	PMID:10318843
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P08575	Human	PMID:10369126
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9NP31	Human	PMID:10553045
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9H204	Human	PMID:10656681
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q07666	Human	PMID:11278465
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q13444	Human	PMID:11741929
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:O95971	Human	PMID:11978774
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P08575	Human	PMID:14625311
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q13432	Human	PMID:14757743
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P43405	Human	PMID:15536084
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P10747	Human	PMID:15554700
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9NP31	Human	PMID:15827961
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9YJQ8	Human	PMID:16051843
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P20749	Human	PMID:16099425
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q07666	Human	PMID:16107303
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P25963	Human	PMID:16195219
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P56945	Human	PMID:16245368
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q6P5Z4	Human	PMID:16245368
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P43403	Human	PMID:16461343
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9Y2R2	Human	PMID:16461343
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9NP31	Human	PMID:16839418
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P01730	Human	PMID:16888650
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P04150	Human	PMID:16888650
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P07900	Human	PMID:16888650
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q07666	Human	PMID:16888650
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9H204	Human	PMID:16899217
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:O43561	Human	PMID:16938345
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P01730	Human	PMID:17005671
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P22575	Human	PMID:17005671
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P22575	Human	PMID:17382937
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P13688	Human	PMID:18424730
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P0CG48	Human	PMID:18539162
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P08575	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P29350	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9Y2R2	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9BZL6	Human	PMID:19192391
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q13761	Human	PMID:20100835
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9Y2R2	Human	PMID:21719704
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q04759	Human	PMID:21964608
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q8N1K5-1	Human	PMID:23460737
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:O14672	Human	PMID:25036101
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q5VV42	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q9BRK4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q13444	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P23771	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:O15117	Human	PMID:27335501
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q5VWT5	Human	PMID:27335501
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P36888	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P07900	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P08575	Human	PMID:7507203
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P04216	Human	PMID:7513706
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q07666	Human	PMID:7852312
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q8VXD2	Human	PMID:7852312
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P29350	Human	PMID:8114715
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P08575	Human	PMID:8576115
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P37198	Human	PMID:8650207
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P43405	Human	PMID:8798676
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q07666	Human	PMID:9045636
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:P22575	Human	PMID:9175835
Molecular Function	GO:0005515	protein binding	LCK	IPI	UniProtKB:Q12959	Human	PMID:9341123
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:P08575	Mouse	MGI:MGI:5142398|PMID:8576115
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:P06800	Mouse	MGI:MGI:5508309|PMID:9581568
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:Q07666	Mouse	MGI:MGI:4441153|PMID:9045636
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:P06800	Mouse	MGI:MGI:5509193|PMID:8570203
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:O92972|UniProtKB:P27958	Mouse	MGI:MGI:4839452|PMID:15784897
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:P49710	Mouse	MGI:MGI:3694161|PMID:10713104
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:P06332	Mouse	MGI:MGI:4839467|PMID:7486703
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:O92972|UniProtKB:P27958	Mouse	MGI:MGI:4441130|PMID:14993658
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:Q9QXK9	Mouse	MGI:MGI:1347688|PMID:10553045
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:P49070	Mouse	MGI:MGI:3588813|PMID:16111633
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:P01731|UniProtKB:P06332	Mouse	MGI:MGI:5532887|PMID:24034254
Molecular Function	GO:0005515	protein binding	Lck	IPI	UniProtKB:P01731|UniProtKB:P06332	Mouse	MGI:MGI:3690806|PMID:7664803
Molecular Function	GO:0005515	protein binding	Lck	IPI	PR:Q9JLY0	Mouse	PMID:20007709
Molecular Function	GO:0005515	protein binding	Lck	IPI	PR:P43404	Mouse	PMID:16501569
Molecular Function	GO:0005515	protein binding	Lck	IPI	PR:Q811D0	Mouse	PMID:15699074
Molecular Function	GO:0005515	protein binding	Lck	IPI	PR:Q80TQ2	Mouse	PMID:16501569
Molecular Function	GO:0005515	protein binding	Lck	IPI	PR:P70315	Mouse	PMID:15699074
Molecular Function	GO:0019901	protein kinase binding	LCK	IPI	UniProtKB:P20936	Human	PMID:8618896
Molecular Function	GO:0019903	protein phosphatase binding	LCK	IPI	UniProtKB:P17706	Human	PMID:22080863
Molecular Function	GO:0019903	protein phosphatase binding	LCK	IPI	UniProtKB:Q9NRW4	Human	PMID:24714587
Molecular Function	GO:0019903	protein phosphatase binding	Lck	IPI	UniProtKB:Q99N11	Mouse	MGI:MGI:5583944|PMID:24714587
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	LCK	IDA		Human	PMID:8506364
Molecular Function	GO:0004713	protein tyrosine kinase activity	LCK	EXP		Human	PMID:12923167
Molecular Function	GO:0004713	protein tyrosine kinase activity	LCK	EXP		Human	PMID:1381360
Molecular Function	GO:0004713	protein tyrosine kinase activity	LCK	EXP		Human	PMID:18697750
Molecular Function	GO:0004713	protein tyrosine kinase activity	LCK	IDA		Human	PMID:214242
Molecular Function	GO:0004713	protein tyrosine kinase activity	LCK	IDA		Human	PMID:8478617
Molecular Function	GO:0004713	protein tyrosine kinase activity	LCK	IMP		Human	PMID:8681956
Molecular Function	GO:0004713	protein tyrosine kinase activity	LCK	EXP		Human	PMID:9799234
Molecular Function	GO:0004713	protein tyrosine kinase activity	Lck	EXP		Mouse	MGI:MGI:3774455|PMID:16709819
Molecular Function	GO:0004713	protein tyrosine kinase activity	Lck	IDA		Mouse	PMID:9169414
Molecular Function	GO:0004713	protein tyrosine kinase activity	Lck	IMP		Mouse	PMID:21487392
Molecular Function	GO:0004713	protein tyrosine kinase activity	Lck	IDA		Mouse	PMID:7499277
Molecular Function	GO:0004713	protein tyrosine kinase activity	Lck	IDA		Mouse	PMID:8175795
Molecular Function	GO:0004713	protein tyrosine kinase activity	Lck	IDA		Rat	PMID:11034334|RGD:1600230
Molecular Function	GO:0044877	protein-containing complex binding	Lck	IDA		Rat	PMID:8104794|RGD:1600238
Molecular Function	GO:0042169	SH2 domain binding	LCK	IPI	UniProtKB:Q78524	Human	PMID:7852312
Molecular Function	GO:0042169	SH2 domain binding	LCK	IPI	UniProtKB:P03406	Human	PMID:8794306
Molecular Function	GO:0042608	T cell receptor binding	LCK	IPI	UniProtKB:P20963	Human	PMID:8681956
Cellular Component	GO:0005911	cell-cell junction	Lck	IDA		Mouse	PMID:23793062
Cellular Component	GO:0030139	endocytic vesicle	Lck	IDA		Rat	PMID:9116282|RGD:1600232
Cellular Component	GO:0070062	extracellular exosome	LCK	HDA		Human	PMID:20458337
Cellular Component	GO:0098978	glutamatergic synapse	Lck	IDA		Rat	PMID:14529711|RGD:2303716
Cellular Component	GO:0001772	immunological synapse	LCK	IDA		Human	PMID:20007709
Cellular Component	GO:0045121	membrane raft	LCK	IDA		Human	PMID:12150984
Cellular Component	GO:0045121	membrane raft	LCK	IDA		Human	PMID:12732664
Cellular Component	GO:0045121	membrane raft	Lck	IDA		Rat	PMID:18178839|RGD:2316555
Cellular Component	GO:0000242	pericentriolar material	LCK	IDA		Human	PMID:7513706
Cellular Component	GO:0005886	plasma membrane	LCK	IDA		Human	PMID:12150984
Cellular Component	GO:0005886	plasma membrane	Lck	IDA		Mouse	MGI:MGI:5693239|PMID:3262426
Cellular Component	GO:0005886	plasma membrane	Lck	IDA		Rat	PMID:9116282|RGD:1600232
Cellular Component	GO:0099091	postsynaptic specialization, intracellular component	Lck	IDA		Rat	PMID:14529711|RGD:2303716
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	LCK	IDA		Human	PMID:16116473
Biological Process	GO:0007568	aging	Lck	IEP		Rat	PMID:15712602|RGD:1600226
Biological Process	GO:0006915	apoptotic process	Lck	IEP		Rat	PMID:7930951|RGD:1600237
Biological Process	GO:0050853	B cell receptor signaling pathway	Lck	IDA		Mouse	PMID:7499277
Biological Process	GO:0007166	cell surface receptor signaling pathway	Lck	IDA		Mouse	PMID:9177270
Biological Process	GO:0038094	Fc-gamma receptor signaling pathway	LCK	IDA		Human	PMID:8478617
Biological Process	GO:0042492	gamma-delta T cell differentiation	Lck	IMP	MGI:MGI:1857211	Mouse	PMID:7807014
Biological Process	GO:0035556	intracellular signal transduction	LCK	IDA		Human	PMID:8681956
Biological Process	GO:0006882	intracellular zinc ion homeostasis	LCK	IEP		Human	PMID:11739864
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	LCK	IDA		Human	PMID:8478617
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	LCK	IMP		Human	PMID:11606584
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	LCK	IMP		Human	PMID:8681956
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Lck	IDA		Mouse	PMID:8175795
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Lck	IDA		Mouse	PMID:7499277
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Lck	IDA		Rat	PMID:11034334|RGD:1600230
Biological Process	GO:0045588	positive regulation of gamma-delta T cell differentiation	Lck	IMP	MGI:MGI:1857211	Mouse	PMID:7807014
Biological Process	GO:0010628	positive regulation of gene expression	Lck	IDA		Mouse	PMID:21357543
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	LCK	IMP		Human	PMID:27400149
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	LCK	IMP		Human	PMID:16116473
Biological Process	GO:1903039	positive regulation of leukocyte cell-cell adhesion	LCK	IMP		Human	PMID:27400149
Biological Process	GO:0050870	positive regulation of T cell activation	LCK	IDA		Human	PMID:8943371
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Lck	IDA		Mouse	PMID:11254359
Biological Process	GO:0070474	positive regulation of uterine smooth muscle contraction	Lck	IMP		Rat	PMID:19208792|RGD:2316554
Biological Process	GO:0046777	protein autophosphorylation	Lck	IDA		Mouse	PMID:8175795
Biological Process	GO:0046777	protein autophosphorylation	Lck	IDA		Rat	PMID:11034334|RGD:1600230
Biological Process	GO:0006468	protein phosphorylation	LCK	IDA		Human	PMID:214242
Biological Process	GO:0006468	protein phosphorylation	Lck	IDA		Mouse	PMID:9169414
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	Lck	IGI	MGI:MGI:88327	Mouse	PMID:21245484
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway	Lck	IDA		Mouse	PMID:14752163
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Lck	IDA		Mouse	MGI:MGI:3687439|PMID:1505025
Biological Process	GO:0042542	response to hydrogen peroxide	Lck	IDA		Rat	PMID:9325251|RGD:1600233
Biological Process	GO:0009612	response to mechanical stimulus	Lck	IMP		Rat	PMID:19208792|RGD:2316554
Biological Process	GO:0010038	response to metal ion	Lck	IDA		Rat	PMID:11477538|RGD:1600227
Biological Process	GO:0009410	response to xenobiotic stimulus	LCK	IDA		Human	PMID:16116473
Biological Process	GO:0010043	response to zinc ion	Lck	IEP		Rat	PMID:14652378|RGD:1600224
Biological Process	GO:0030217	T cell differentiation	LCK	IMP		Human	PMID:1579166

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern