Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lcn2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LCN2
- Mouse genes Lcn2
- Rat genes Lcn2
- Zfish genes lcn15,ptgdsa
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lcn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1903981	enterobactin binding	LCN2	IDA		Human	PMID:27780864
Molecular Function	GO:1903981	enterobactin binding	Lcn2	IPI	CHEBI:28855	Rat	PMID:26004810\|RGD:126790532
Molecular Function	GO:0042802	identical protein binding	LCN2	IPI	UniProtKB:P80188	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Lcn2	IPI	RGD:69408	Rat	PMID:17148685\|RGD:2316510
Molecular Function	GO:0005506	iron ion binding	LCN2	IDA		Human	PMID:27780864
Molecular Function	GO:0005506	iron ion binding	Lcn2	IDA		Mouse	MGI:MGI:4821076\|PMID:16377569
Molecular Function	GO:0005506	iron ion binding	Lcn2	IDA		Mouse	MGI:MGI:4820913\|PMID:20550936
Molecular Function	GO:0140315	iron ion sequestering activity	LCN2	IDA		Human	PMID:27780864
Molecular Function	GO:0002020	protease binding	Lcn2	IPI	RGD:621320	Rat	PMID:17148685\|RGD:2316510
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:A0A1U9X8X8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:B3EWG5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:O14595	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:O43715	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:O60895	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:O96006	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P07237	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P13667	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P15692-12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P20396	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P24863	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P49069	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P49419-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P54646	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P57075-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:P60059	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q12837	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q13049	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q13526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q14119	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q17RF5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q5TA76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q5W5X9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q6ISS4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q6NZ36-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q7Z4H3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q86Y79	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q8IXL7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q8IYX1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q8WXI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q969H8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q969M7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q969S2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q96FA3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q96JG8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q96LC9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q99757	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q99816	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9BWG6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9BXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9H0D6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9H1P6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9H6B4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9NXW9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9UGP5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9UIQ6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9UKJ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9UL33-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9Y6T4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LCN2	IPI	UniProtKB:Q9Y6Y9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Lcn2	IPI	UniProtKB:Q9D9E0	Mouse	MGI:MGI:4821076\|PMID:16377569
Cellular Component	GO:0005737	cytoplasm	Lcn2	IDA		Rat	PMID:24916903\|RGD:126790489
Cellular Component	GO:0005737	cytoplasm	Lcn2	IDA		Rat	PMID:32174475\|RGD:126790555
Cellular Component	GO:0005829	cytosol	Lcn2	IDA		Rat	PMID:17148685\|RGD:2316510
Cellular Component	GO:0070062	extracellular exosome	LCN2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	LCN2	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	LCN2	HDA		Human	PMID:27068509
Cellular Component	GO:0005576	extracellular region	Lcn2	IDA		Mouse	MGI:MGI:4821076\|PMID:16377569
Cellular Component	GO:0005615	extracellular space	LCN2	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	LCN2	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	LCN2	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	LCN2	IDA		Human	PMID:27780864
Cellular Component	GO:0005615	extracellular space	Lcn2	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Lcn2	IDA		Mouse	PMID:29402223
Cellular Component	GO:0005615	extracellular space	Lcn2	IDA		Rat	PMID:20057160\|RGD:2316490
Cellular Component	GO:0005615	extracellular space	Lcn2	IDA		Rat	PMID:23431168\|RGD:126781758
Biological Process	GO:0006953	acute-phase response	Lcn2	IEP		Rat	PMID:22249220\|RGD:126781756
Biological Process	GO:1904646	cellular response to amyloid-beta	Lcn2	IEP		Rat	PMID:24853299\|RGD:126781834
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Lcn2	IDA		Rat	PMID:19129400\|RGD:2316500
Biological Process	GO:0036295	cellular response to increased oxygen levels	Lcn2	IEP		Rat	PMID:24916903\|RGD:126790489
Biological Process	GO:0071347	cellular response to interleukin-1	Lcn2	IEP		Rat	PMID:19329498\|RGD:2316495
Biological Process	GO:0071347	cellular response to interleukin-1	Lcn2	IEP		Rat	PMID:22249220\|RGD:126781756
Biological Process	GO:0071354	cellular response to interleukin-6	Lcn2	IEP		Rat	PMID:22249220\|RGD:126781756
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Lcn2	IEP		Rat	PMID:19329498\|RGD:2316495
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Lcn2	IEP		Rat	PMID:25412834\|RGD:126781755
Biological Process	GO:0031669	cellular response to nutrient levels	Lcn2	IEP		Rat	PMID:17356516\|RGD:2303047
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Lcn2	IEP		Rat	PMID:24916903\|RGD:126790489
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Lcn2	IEP		Rat	PMID:19329498\|RGD:2316495
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Lcn2	IEP		Rat	PMID:22249220\|RGD:126781756
Biological Process	GO:0071481	cellular response to X-ray	Lcn2	IEP		Rat	PMID:23331620\|RGD:126790570
Biological Process	GO:0042742	defense response to bacterium	LCN2	IDA		Human	PMID:27780864
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Lcn2	IDA		Mouse	PMID:16377569
Biological Process	GO:0045087	innate immune response	Lcn2	IMP		Mouse	MGI:MGI:3617303\|PMID:16446425
Biological Process	GO:0007616	long-term memory	Lcn2	IMP		Rat	PMID:32174475\|RGD:126790555
Biological Process	GO:0110091	negative regulation of hippocampal neuron apoptotic process	Lcn2	IMP		Rat	PMID:32174475\|RGD:126790555
Biological Process	GO:0043065	positive regulation of apoptotic process	Lcn2	IGI	RGD:1594658	Rat	PMID:26013918\|RGD:126781745
Biological Process	GO:0031346	positive regulation of cell projection organization	Lcn2	IDA		Rat	PMID:19129400\|RGD:2316500
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Lcn2	IMP		Mouse	MGI:MGI:4940471\|PMID:20332347
Biological Process	GO:0010595	positive regulation of endothelial cell migration	Lcn2	IDA		Rat	PMID:25557118\|RGD:126790477
Biological Process	GO:1905956	positive regulation of endothelial tube morphogenesis	Lcn2	IDA		Rat	PMID:25557118\|RGD:126790477
Biological Process	GO:0010628	positive regulation of gene expression	Lcn2	IDA		Rat	PMID:19860839\|RGD:2316493
Biological Process	GO:1904440	positive regulation of iron ion import across plasma membrane	Lcn2	IDA		Rat	PMID:25557118\|RGD:126790477
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Lcn2	IMP		Rat	PMID:30574656\|RGD:126781752
Biological Process	GO:1901216	positive regulation of neuron death	Lcn2	IDA		Rat	PMID:26004810\|RGD:126790532
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Lcn2	IDA		Rat	PMID:25557118\|RGD:126790477
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Lcn2	IMP		Rat	PMID:30574656\|RGD:126781752
Biological Process	GO:0009617	response to bacterium	Lcn2	IEP		Mouse	PMID:23012479
Biological Process	GO:0009617	response to bacterium	Lcn2	IEP		Rat	PMID:19303090\|RGD:2316497
Biological Process	GO:0009637	response to blue light	Lcn2	IEP		Rat	PMID:30574656\|RGD:126781752
Biological Process	GO:0009750	response to fructose	Lcn2	IEP		Rat	PMID:24587658\|RGD:126790567
Biological Process	GO:0009635	response to herbicide	Lcn2	IDA		Rat	PMID:19129400\|RGD:2316500
Biological Process	GO:0010040	response to iron(II) ion	Lcn2	IEP		Rat	PMID:23416150\|RGD:126790480
Biological Process	GO:0010046	response to mycotoxin	Lcn2	IEP		Rat	PMID:18308701\|RGD:2316503
Biological Process	GO:0031667	response to nutrient levels	Lcn2	IEP		Rat	PMID:19221211\|RGD:2316498
Biological Process	GO:0006979	response to oxidative stress	Lcn2	IEP		Rat	PMID:17553663\|RGD:2316507
Biological Process	GO:0009636	response to toxic substance	Lcn2	IEP		Rat	PMID:22366155\|RGD:126790568
Biological Process	GO:0009615	response to virus	Lcn2	IDA		Mouse	PMID:2542864
Biological Process	GO:0009410	response to xenobiotic stimulus	Lcn2	IMP		Rat	PMID:19860839\|RGD:2316493
Biological Process	GO:0009410	response to xenobiotic stimulus	Lcn2	IEP		Rat	PMID:20043115\|RGD:2316492
Biological Process	GO:0007614	short-term memory	Lcn2	IMP		Rat	PMID:32174475\|RGD:126790555
Biological Process	GO:0015891	siderophore transport	Lcn2	IDA		Mouse	MGI:MGI:4821076\|PMID:16377569
Biological Process	GO:0015891	siderophore transport	Lcn2	IMP		Mouse	MGI:MGI:4820913\|PMID:20550936

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.