Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LCT
  • Mouse genes Lct
  • Rat genes Lct
  • Zfish genes lct
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lct

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008422	beta-glucosidase activity	LCT	IDA		Human	PMID:12594539
Molecular Function	GO:0008422	beta-glucosidase activity	LCT	IDA		Human	PMID:3929764
Molecular Function	GO:0008422	beta-glucosidase activity	Lct	IDA		Rat	PMID:4752949|RGD:151356630
Molecular Function	GO:0004336	galactosylceramidase activity	Lct	IDA		Rat	PMID:4752949|RGD:151356630
Molecular Function	GO:0004348	glucosylceramidase activity	Lct	IDA		Rat	PMID:4752949|RGD:151356630
Molecular Function	GO:0000016	lactase activity	LCT	IDA		Human	PMID:12594539
Molecular Function	GO:0000016	lactase activity	LCT	IMP		Human	PMID:16400612
Molecular Function	GO:0000016	lactase activity	LCT	IDA		Human	PMID:3929764
Molecular Function	GO:0000016	lactase activity	LCT	IDA		Human	PMID:9762914
Molecular Function	GO:0000016	lactase activity	Lct	IDA		Rat	PMID:12023280|RGD:1299293
Molecular Function	GO:0000016	lactase activity	Lct	IDA		Rat	PMID:4752949|RGD:151356630
Molecular Function	GO:0140749	phlorizin hydrolase activity	LCT	IDA		Human	PMID:12594539
Molecular Function	GO:0140749	phlorizin hydrolase activity	LCT	IDA		Human	PMID:3929764
Molecular Function	GO:0140749	phlorizin hydrolase activity	LCT	IDA		Human	PMID:9762914
Molecular Function	GO:0140749	phlorizin hydrolase activity	Lct	IDA		Rat	PMID:4752949|RGD:151356630
Molecular Function	GO:0042803	protein homodimerization activity	LCT	IDA		Human	PMID:9593732
Molecular Function	GO:0016740	transferase activity	Lct	IDA		Rat	PMID:12023280|RGD:1299293
Cellular Component	GO:0005903	brush border	Lct	IDA		Rat	PMID:12023280|RGD:1299293
Cellular Component	GO:0098591	external side of apical plasma membrane	LCT	IDA		Human	PMID:9593732
Biological Process	GO:2000892	cellobiose catabolic process	LCT	IDA		Human	PMID:3929764
Biological Process	GO:2000892	cellobiose catabolic process	Lct	IDA		Rat	PMID:4752949|RGD:151356630
Biological Process	GO:0046477	glycosylceramide catabolic process	Lct	IDA		Rat	PMID:4752949|RGD:151356630
Biological Process	GO:0005990	lactose catabolic process	LCT	IDA		Human	PMID:12594539
Biological Process	GO:0005990	lactose catabolic process	LCT	IDA		Human	PMID:3929764
Biological Process	GO:0005990	lactose catabolic process	LCT	IDA		Human	PMID:9762914
Biological Process	GO:0005990	lactose catabolic process	Lct	IDA		Rat	PMID:4752949|RGD:151356630
Biological Process	GO:1901733	quercetin catabolic process	LCT	IDA		Human	PMID:12594539
Biological Process	GO:0043627	response to estrogen	Lct	IEP		Rat	PMID:16396664|RGD:1600246
Biological Process	GO:0045471	response to ethanol	Lct	IDA		Rat	PMID:15849819|RGD:1600257
Biological Process	GO:0009725	response to hormone	Lct	IEP		Rat	PMID:17190105|RGD:1600241
Biological Process	GO:0001666	response to hypoxia	Lct	IDA		Rat	PMID:12773704|RGD:1600260
Biological Process	GO:0010040	response to iron(II) ion	Lct	IDA		Rat	PMID:16081762|RGD:1600248
Biological Process	GO:0010288	response to lead ion	Lct	IDA		Rat	PMID:16092086|RGD:1600247
Biological Process	GO:0010045	response to nickel cation	Lct	IDA		Rat	PMID:16819762|RGD:1600243
Biological Process	GO:0007584	response to nutrient	Lct	IDA		Rat	PMID:16497337|RGD:1600244
Biological Process	GO:0010033	response to organic substance	Lct	IDA		Rat	PMID:12428451|RGD:1600261
Biological Process	GO:0042594	response to starvation	Lct	IEP		Rat	PMID:17190105|RGD:1600241
Biological Process	GO:0009744	response to sucrose	Lct	IEP		Rat	PMID:17190105|RGD:1600241
Biological Process	GO:0009410	response to xenobiotic stimulus	Lct	IDA		Rat	PMID:17147060|RGD:1600242

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern