Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LDHA
  • Mouse genes Ldha
  • Rat genes Ldha
  • Zfish genes ldha
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ldha

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	LDHA	HDA		Human	PMID:25468996
Molecular Function	GO:0042802	identical protein binding	LDHA	IPI	UniProtKB:P00338	Human	PMID:21988832
Molecular Function	GO:0042802	identical protein binding	LDHA	IPI	UniProtKB:P00338	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	LDHA	IPI	UniProtKB:P00338	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	LDHA	IPI	UniProtKB:P00338	Human	PMID:34381247
Molecular Function	GO:0042802	identical protein binding	Ldha	IDA		Rat	PMID:7138505|RGD:1600287
Molecular Function	GO:0019900	kinase binding	Ldha	IPI	RGD:70497	Rat	PMID:17572440|RGD:5132880
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	LDHA	IMP		Human	PMID:34381247
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldha	IMP	MGI:MGI:2384559	Mouse	PMID:7534515
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldha	IMP	MGI:MGI:2384559	Mouse	PMID:8224816
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldha	IDA		Mouse	PMID:21041631
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldha	IDA		Mouse	PMID:7323947
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldha	IMP	MGI:MGI:3776263	Mouse	PMID:3796661
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldha	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0004457	lactate dehydrogenase activity	Ldha	IMP	MGI:MGI:2384559	Mouse	PMID:8224816
Molecular Function	GO:0004457	lactate dehydrogenase activity	Ldha	IDA		Rat	PMID:7138505|RGD:1600287
Molecular Function	GO:0051287	NAD binding	Ldha	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0005515	protein binding	LDHA	IPI	UniProtKB:P07195	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	LDHA	IPI	UniProtKB:P11142	Human	PMID:23523103
Molecular Function	GO:0005515	protein binding	LDHA	IPI	UniProtKB:P07195	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LDHA	IPI	UniProtKB:P07195	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LDHA	IPI	UniProtKB:C0HLV8	Human	PMID:33406399
Molecular Function	GO:0005515	protein binding	LDHA	IPI	UniProtKB:Q8NFG4	Human	PMID:34381247
Molecular Function	GO:0005515	protein binding	Ldha	IPI	UniProtKB:Q60668	Mouse	MGI:MGI:3693398|PMID:12107167
Molecular Function	GO:0005515	protein binding	Ldha	IPI	RGD:2997	Rat	PMID:7138505|RGD:1600287
Cellular Component	GO:0005829	cytosol	Ldha	IDA		Mouse	PMID:17572440
Cellular Component	GO:0005829	cytosol	Ldha	IDA		Mouse	PMID:11980919
Cellular Component	GO:0070062	extracellular exosome	LDHA	HDA		Human	PMID:11487543
Cellular Component	GO:0070062	extracellular exosome	LDHA	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	LDHA	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	LDHA	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	LDHA	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	Ldha	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005634	nucleus	LDHA	HDA		Human	PMID:21630459
Cellular Component	GO:1990204	oxidoreductase complex	LDHA	IPI		Human	PMID:24816116
Cellular Component	GO:0035686	sperm fibrous sheath	Ldha	IDA		Mouse	PMID:16687649
Biological Process	GO:0031668	cellular response to extracellular stimulus	Ldha	IDA		Mouse	PMID:10322635
Biological Process	GO:0019661	glucose catabolic process to lactate via pyruvate	Ldha	IMP	MGI:MGI:2384559	Mouse	PMID:8224816
Biological Process	GO:0006089	lactate metabolic process	LDHA	IDA		Human	PMID:24816116
Biological Process	GO:0006089	lactate metabolic process	Ldha	IDA		Rat	PMID:17447164|RGD:1624966
Biological Process	GO:0019674	NAD metabolic process	Ldha	IDA		Rat	PMID:17447164|RGD:1624966
Biological Process	GO:0043065	positive regulation of apoptotic process	Ldha	IDA		Rat	PMID:9465046|RGD:1600282
Biological Process	GO:0048569	post-embryonic animal organ development	Ldha	IEP		Rat	PMID:6849973|RGD:1600284
Biological Process	GO:0042867	pyruvate catabolic process	Ldha	IDA		Mouse	PMID:21041631
Biological Process	GO:0042867	pyruvate catabolic process	Ldha	IMP	MGI:MGI:2384559	Mouse	PMID:8224816
Biological Process	GO:0006090	pyruvate metabolic process	LDHA	IDA		Human	PMID:24816116
Biological Process	GO:0051591	response to cAMP	Ldha	IEP		Rat	PMID:6300127|RGD:1600285
Biological Process	GO:0043627	response to estrogen	Ldha	IEP		Rat	PMID:17010207|RGD:1600269
Biological Process	GO:0009749	response to glucose	Ldha	IEP		Rat	PMID:11457846|RGD:1600279
Biological Process	GO:0042542	response to hydrogen peroxide	Ldha	IEP		Rat	PMID:16154111|RGD:1600270
Biological Process	GO:0001666	response to hypoxia	Ldha	IEP		Rat	PMID:12678657|RGD:1600275
Biological Process	GO:0001666	response to hypoxia	ldha	IDA		Zfish	PMID:16709914
Biological Process	GO:0007584	response to nutrient	Ldha	IEP		Rat	PMID:15110778|RGD:1600272
Biological Process	GO:0014070	response to organic cyclic compound	Ldha	IEP		Rat	PMID:7758843|RGD:1600283
Biological Process	GO:0009410	response to xenobiotic stimulus	Ldha	IEP		Rat	PMID:11176097|RGD:1600280

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern