Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LDHB
  • Mouse genes Ldhb
  • Rat genes Ldhb
  • Zfish genes ldhba,ldhbb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ldhb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	LDHB	IPI	UniProtKB:P07195	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	LDHB	IPI	UniProtKB:P07195	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	LDHB	IPI	UniProtKB:P07195	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	LDHB	IPI	UniProtKB:P07195	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Ldhb	IDA		Rat	PMID:7138505|RGD:1600287
Molecular Function	GO:0019900	kinase binding	Ldhb	IPI	RGD:619877	Rat	PMID:17572440|RGD:5132880
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	LDHB	IDA		Human	PMID:27618187
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldhb	IDA		Mouse	PMID:16582413
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldhb	IDA		Mouse	PMID:1914521
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldhb	IDA		Mouse	PMID:5764873
Molecular Function	GO:0004459	L-lactate dehydrogenase activity	Ldhb	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0004457	lactate dehydrogenase activity	Ldhb	IDA		Rat	PMID:7138505|RGD:1600287
Molecular Function	GO:0051287	NAD binding	Ldhb	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P00338	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:Q5S007	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P00338-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P50542	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P00338-3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P00338	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P00338	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P00338-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LDHB	IPI	UniProtKB:C0HLV8	Human	PMID:33406399
Molecular Function	GO:0005515	protein binding	Ldhb	IPI	RGD:2996	Rat	PMID:7138505|RGD:1600287
Cellular Component	GO:0005829	cytosol	LDHB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Ldhb	IDA		Mouse	PMID:17572440
Cellular Component	GO:0070062	extracellular exosome	LDHB	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	LDHB	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	LDHB	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	LDHB	HDA		Human	PMID:19946888
Cellular Component	GO:0045121	membrane raft	LDHB	IDA		Human	PMID:25204797
Cellular Component	GO:0005743	mitochondrial inner membrane	LDHB	IDA		Human	PMID:27618187
Cellular Component	GO:0005739	mitochondrion	Ldhb	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043209	myelin sheath	Ldhb	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:1990204	oxidoreductase complex	LDHB	IPI		Human	PMID:15117937
Biological Process	GO:0006089	lactate metabolic process	LDHB	IDA		Human	PMID:15117937
Biological Process	GO:0006089	lactate metabolic process	Ldhb	IDA		Rat	PMID:17447164|RGD:1624966
Biological Process	GO:0019674	NAD metabolic process	Ldhb	IDA		Rat	PMID:17447164|RGD:1624966
Biological Process	GO:0006090	pyruvate metabolic process	LDHB	IDA		Human	PMID:15117937

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern