Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ldlr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LDLR
- Mouse genes Ldlr
- Rat genes Ldlr
- Zfish genes ldlra,ldlrb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ldlr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Ldlr	IPI	UniProtKB:P12023:PRO_0000000119	Mouse	MGI:MGI:5902678\|PMID:22383525
Molecular Function	GO:0042802	identical protein binding	LDLR	IPI	UniProtKB:P01130	Human	PMID:26526611
Molecular Function	GO:0030169	low-density lipoprotein particle binding	LDLR	IMP		Human	PMID:6299582
Molecular Function	GO:0030169	low-density lipoprotein particle binding	Ldlr	IDA		Mouse	PMID:7848292
Molecular Function	GO:0030169	low-density lipoprotein particle binding	Ldlr	IDA		Mouse	PMID:15741654
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	LDLR	IDA		Human	PMID:6091915
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	LDLR	IMP		Human	PMID:6299582
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	LDLR	IDA		Human	PMID:8626535
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	Ldlr	IMP	MGI:MGI:1857212	Mouse	PMID:17148552
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	Ldlr	IDA		Mouse	PMID:12072432
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	Ldlr	IDA		Rat	PMID:3559401\|RGD:2324634
Molecular Function	GO:0005041	low-density lipoprotein particle receptor activity	ldlra	IMP	ZFIN:ZDB-MRPHLNO-150312-1	Zfish	PMID:25201834
Molecular Function	GO:0060090	molecular adaptor activity	LDLR	EXP		Human	PMID:22091758
Molecular Function	GO:0002020	protease binding	LDLR	IPI	UniProtKB:Q8NBP7:PRO_0000027120	Human	PMID:22081141
Molecular Function	GO:0002020	protease binding	LDLR	IPI	UniProtKB:Q8NBP7:PRO_0000027121	Human	PMID:22081141
Molecular Function	GO:0002020	protease binding	LDLR	IPI	UniProtKB:Q8NBP7	Human	PMID:22848640
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q60841	Human	PMID:10571240
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q5SW96	Human	PMID:12221107
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q8NBP7	Human	PMID:17452316
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q8NBP7	Human	PMID:17461796
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q8NBP7-1	Human	PMID:18250299
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q8NBP7-1	Human	PMID:18753623
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:P02649	Human	PMID:20030366
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:P30533	Human	PMID:20030366
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:P02749	Human	PMID:20223219
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q8NBP7	Human	PMID:22081141
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:D3ZAR1	Human	PMID:22509010
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:P03522	Human	PMID:23589850
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:P02649	Human	PMID:24447298
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:P04114	Human	PMID:24447298
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q8NBP7	Human	PMID:25613181
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:P30533	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:Q9H2K0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLR	IPI	UniProtKB:P0DTC2	Human	PMID:33420426
Molecular Function	GO:0005515	protein binding	Ldlr	IPI	PR:Q8C142	Mouse	PMID:12746448
Molecular Function	GO:0005515	protein binding	Ldlr	IPI	PR:Q8BVL3	Mouse	PMID:12169628
Molecular Function	GO:0005515	protein binding	Ldlr	IPI	RGD:621161	Rat	PMID:15044370\|RGD:1581827
Molecular Function	GO:0030229	very-low-density lipoprotein particle receptor activity	LDLR	IDA		Human	PMID:8626535
Molecular Function	GO:0030229	very-low-density lipoprotein particle receptor activity	Ldlr	IDA		Mouse	PMID:16166565
Cellular Component	GO:0045177	apical part of cell	Ldlr	IDA		Mouse	MGI:MGI:5446858\|PMID:22848640
Cellular Component	GO:0016323	basolateral plasma membrane	Ldlr	IDA		Mouse	MGI:MGI:5446858\|PMID:22848640
Cellular Component	GO:0005901	caveola	Ldlr	IDA		Rat	PMID:12646183\|RGD:1298981
Cellular Component	GO:0009986	cell surface	LDLR	IDA		Human	PMID:17461796
Cellular Component	GO:0009986	cell surface	Ldlr	IDA		Mouse	MGI:MGI:5446858\|PMID:22848640
Cellular Component	GO:0009986	cell surface	Ldlr	IDA		Mouse	PMID:26965651
Cellular Component	GO:0005905	clathrin-coated pit	LDLR	IDA		Human	PMID:15166224
Cellular Component	GO:0005905	clathrin-coated pit	LDLR	IDA		Human	PMID:6091915
Cellular Component	GO:0005769	early endosome	LDLR	IDA		Human	PMID:15166224
Cellular Component	GO:0005769	early endosome	LDLR	IDA		Human	PMID:17461796
Cellular Component	GO:0005769	early endosome	Ldlr	IDA		Mouse	PMID:26965651
Cellular Component	GO:0005769	early endosome	Ldlr	IDA		Mouse	PMID:11092755
Cellular Component	GO:0005768	endosome	Ldlr	IDA		Mouse	PMID:12746448
Cellular Component	GO:0009897	external side of plasma membrane	LDLR	IDA		Human	PMID:15166224
Cellular Component	GO:0005615	extracellular space	Ldlr	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005794	Golgi apparatus	LDLR	IDA		Human	PMID:17461796
Cellular Component	GO:0005770	late endosome	LDLR	IDA		Human	PMID:17461796
Cellular Component	GO:0005770	late endosome	Ldlr	IDA		Mouse	PMID:11092755
Cellular Component	GO:0005764	lysosome	LDLR	IDA		Human	PMID:15166224
Cellular Component	GO:0005764	lysosome	LDLR	IDA		Human	PMID:17461796
Cellular Component	GO:0005764	lysosome	Ldlr	IDA		Mouse	PMID:11092755
Cellular Component	GO:0016020	membrane	LDLR	HDA		Human	PMID:19946888
Cellular Component	GO:1990666	PCSK9-LDLR complex	LDLR	IPI		Human	PMID:22081141
Cellular Component	GO:1990666	PCSK9-LDLR complex	LDLR	IDA		Human	PMID:22081141
Cellular Component	GO:1990666	PCSK9-LDLR complex	LDLR	IDA		Human	PMID:22848640
Cellular Component	GO:0005886	plasma membrane	Ldlr	IDA		Mouse	MGI:MGI:4415751\|PMID:20005821
Cellular Component	GO:0005886	plasma membrane	Ldlr	IDA		Rat	PMID:15044370\|RGD:1581827
Cellular Component	GO:0043235	receptor complex	LDLR	IDA		Human	PMID:23382219
Cellular Component	GO:0055038	recycling endosome membrane	Ldlr	IDA		Rat	PMID:10468577\|RGD:4892345
Cellular Component	GO:0036477	somatodendritic compartment	Ldlr	IDA		Mouse	MGI:MGI:3794899\|PMID:18341993
Cellular Component	GO:0097443	sorting endosome	Ldlr	IDA		Mouse	PMID:11092755
Biological Process	GO:0007568	aging	Ldlr	IEP		Rat	PMID:16741953\|RGD:1581819
Biological Process	GO:0097242	amyloid-beta clearance	Ldlr	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:4415751\|PMID:20005821
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Ldlr	IDA		Mouse	MGI:MGI:5902678\|PMID:22383525
Biological Process	GO:0048844	artery morphogenesis	Ldlr	IMP		Mouse	MGI:MGI:5581894\|PMID:22927332
Biological Process	GO:0071398	cellular response to fatty acid	Ldlr	IGI	RNAcentral:URS0000329B12_10090	Mouse	MGI:MGI:5659826\|PMID:24255059
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ldlra	IMP	ZFIN:ZDB-GENO-180307-2	Zfish	PMID:29187523
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	LDLR	IMP		Human	PMID:6299582
Biological Process	GO:0042632	cholesterol homeostasis	LDLR	IMP		Human	PMID:17142622
Biological Process	GO:0042632	cholesterol homeostasis	LDLR	IGI	UniProtKB:P02649	Human	PMID:24412220
Biological Process	GO:0042632	cholesterol homeostasis	LDLR	IMP		Human	PMID:6299582
Biological Process	GO:0042632	cholesterol homeostasis	Ldlr	IGI	RNAcentral:URS0000070CD2_10090	Mouse	MGI:MGI:5896906\|PMID:25524771
Biological Process	GO:0042632	cholesterol homeostasis	Ldlr	IMP		Mouse	PMID:23580231
Biological Process	GO:0042632	cholesterol homeostasis	Ldlr	IGI	MGI:MGI:88052	Mouse	PMID:11120757
Biological Process	GO:0042632	cholesterol homeostasis	Ldlr	IMP	MGI:MGI:1857212	Mouse	PMID:12746448
Biological Process	GO:0042632	cholesterol homeostasis	Ldlr	IMP	MGI:MGI:1857212	Mouse	PMID:9788969
Biological Process	GO:0042632	cholesterol homeostasis	Ldlr	IEP		Rat	PMID:20028367\|RGD:21410185
Biological Process	GO:0042632	cholesterol homeostasis	ldlra	IMP	ZFIN:ZDB-GENO-180307-2	Zfish	PMID:29187523
Biological Process	GO:0070508	cholesterol import	LDLR	IMP		Human	PMID:6299582
Biological Process	GO:0070508	cholesterol import	Ldlr	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0008203	cholesterol metabolic process	Ldlr	IMP	MGI:MGI:1857212	Mouse	PMID:17071966
Biological Process	GO:0030301	cholesterol transport	LDLR	IMP		Human	PMID:17142622
Biological Process	GO:0030301	cholesterol transport	Ldlr	IMP	MGI:MGI:1857212	Mouse	PMID:17148552
Biological Process	GO:0006897	endocytosis	Ldlr	IMP		Rat	PMID:17256088\|RGD:2324632
Biological Process	GO:0051649	establishment of localization in cell	Ldlr	IMP	MGI:MGI:1857212	Mouse	PMID:17148552
Biological Process	GO:0034384	high-density lipoprotein particle clearance	Ldlr	IGI	RNAcentral:URS0000070CD2_10090	Mouse	MGI:MGI:5896906\|PMID:25524771
Biological Process	GO:0030299	intestinal cholesterol absorption	LDLR	IMP		Human	PMID:17142622
Biological Process	GO:0006629	lipid metabolic process	Ldlr	IGI	MGI:MGI:88052	Mouse	PMID:11120757
Biological Process	GO:0042159	lipoprotein catabolic process	Ldlr	IMP	MGI:MGI:1857212	Mouse	PMID:15805190
Biological Process	GO:0042159	lipoprotein catabolic process	Ldlr	IDA		Mouse	PMID:15741654
Biological Process	GO:0042159	lipoprotein catabolic process	Ldlr	IMP	MGI:MGI:1857212	Mouse	PMID:9788969
Biological Process	GO:0042157	lipoprotein metabolic process	Ldlr	IGI	MGI:MGI:88052	Mouse	PMID:11120757
Biological Process	GO:0042157	lipoprotein metabolic process	Ldlr	IGI	MGI:MGI:88052	Mouse	PMID:13130124
Biological Process	GO:0007616	long-term memory	LDLR	IGI	UniProtKB:P02649	Human	PMID:24412220
Biological Process	GO:0007616	long-term memory	Ldlr	IGI	UniProtKB:P02649	Mouse	MGI:MGI:5575733\|PMID:24412220
Biological Process	GO:0034383	low-density lipoprotein particle clearance	LDLR	IMP		Human	PMID:17142622
Biological Process	GO:0034383	low-density lipoprotein particle clearance	LDLR	IMP		Human	PMID:6299582
Biological Process	GO:0034383	low-density lipoprotein particle clearance	Ldlr	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0034383	low-density lipoprotein particle clearance	Ldlr	IDA		Mouse	PMID:26965651
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	Ldlr	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:4415751\|PMID:20005821
Biological Process	GO:0061889	negative regulation of astrocyte activation	Ldlr	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:4415751\|PMID:20005821
Biological Process	GO:0010629	negative regulation of gene expression	Ldlr	IMP		Mouse	MGI:MGI:5659826\|PMID:24255059
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	LDLR	IDA		Human	PMID:17452316
Biological Process	GO:1903979	negative regulation of microglial cell activation	Ldlr	IGI	UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:4415751\|PMID:20005821
Biological Process	GO:0051248	negative regulation of protein metabolic process	Ldlr	IDA		Mouse	MGI:MGI:5902678\|PMID:22383525
Biological Process	GO:0001920	negative regulation of receptor recycling	LDLR	IDA		Human	PMID:17452316
Biological Process	GO:0006909	phagocytosis	Ldlr	IDA		Mouse	MGI:MGI:5902678\|PMID:22383525
Biological Process	GO:0015914	phospholipid transport	Ldlr	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0034381	plasma lipoprotein particle clearance	Ldlr	IDA		Mouse	MGI:MGI:5902678\|PMID:22383525
Biological Process	GO:0010628	positive regulation of gene expression	Ldlr	IGI	RNAcentral:URS0000329B12_10090	Mouse	MGI:MGI:5659826\|PMID:24255059
Biological Process	GO:0010628	positive regulation of gene expression	Ldlr	IGI	UniProtKB:P42227	Mouse	MGI:MGI:5659826\|PMID:24255059
Biological Process	GO:0010628	positive regulation of gene expression	Ldlr	IMP		Mouse	MGI:MGI:5659826\|PMID:24255059
Biological Process	GO:0050729	positive regulation of inflammatory response	Ldlr	IGI	RNAcentral:URS0000329B12_10090	Mouse	MGI:MGI:5659826\|PMID:24255059
Biological Process	GO:1905167	positive regulation of lysosomal protein catabolic process	Ldlr	IDA		Mouse	MGI:MGI:5902678\|PMID:22383525
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	Ldlr	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0010898	positive regulation of triglyceride catabolic process	Ldlr	IMP		Rat	PMID:28469073\|RGD:12910100
Biological Process	GO:0006898	receptor-mediated endocytosis	Ldlr	IDA		Mouse	MGI:MGI:4415751\|PMID:20005821
Biological Process	GO:0006898	receptor-mediated endocytosis	Ldlr	IDA		Mouse	MGI:MGI:5902678\|PMID:22383525
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	LDLR	IMP		Human	PMID:6299582
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	ldlra	IMP	ZFIN:ZDB-MRPHLNO-150312-1	Zfish	PMID:25201834
Biological Process	GO:0090181	regulation of cholesterol metabolic process	Ldlr	IGI	UniProtKB:P02649	Mouse	MGI:MGI:5575733\|PMID:24412220
Biological Process	GO:0019216	regulation of lipid metabolic process	ldlra	IMP	ZFIN:ZDB-MRPHLNO-190212-1	Zfish	PMID:30219383
Biological Process	GO:0010899	regulation of phosphatidylcholine catabolic process	Ldlr	IMP		Mouse	MGI:MGI:3784112\|PMID:18175806
Biological Process	GO:0051246	regulation of protein metabolic process	LDLR	IGI	UniProtKB:P02649	Human	PMID:24412220
Biological Process	GO:0051246	regulation of protein metabolic process	Ldlr	IGI	UniProtKB:P02649	Mouse	MGI:MGI:5575733\|PMID:24412220
Biological Process	GO:0061771	response to caloric restriction	LDLR	IGI	UniProtKB:P02649	Human	PMID:24412220
Biological Process	GO:0061771	response to caloric restriction	Ldlr	IGI	UniProtKB:P02649	Mouse	MGI:MGI:5575733\|PMID:24412220
Biological Process	GO:0032355	response to estradiol	Ldlr	IEP		Rat	PMID:19008317\|RGD:2317989
Biological Process	GO:0032355	response to estradiol	Ldlr	IEP		Rat	PMID:3559401\|RGD:2324634
Biological Process	GO:0043627	response to estrogen	Ldlr	IEP		Rat	PMID:15044370\|RGD:1581827
Biological Process	GO:0045471	response to ethanol	Ldlr	IEP		Rat	PMID:20028367\|RGD:21410185
Biological Process	GO:0033762	response to glucagon	Ldlr	IEP		Rat	PMID:19008317\|RGD:2317989
Biological Process	GO:0009725	response to hormone	Ldlr	IEP		Rat	PMID:17572141\|RGD:2324628
Biological Process	GO:0001666	response to hypoxia	Ldlr	IEP		Rat	PMID:18703410\|RGD:5490256

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.