Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LDLRAP1
  • Mouse genes Ldlrap1
  • Rat genes Ldlrap1
  • Zfish genes ldlrap1a,ldlrap1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ldlrap1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	LDLRAP1	IPI	UniProtKB:P05067	Human	PMID:12805363
Molecular Function	GO:0001540	amyloid-beta binding	Ldlrap1	IPI	UniProtKB:P12023	Mouse	MGI:MGI:3762243|PMID:17727637
Molecular Function	GO:0035650	AP-1 adaptor complex binding	LDLRAP1	IDA		Human	PMID:12451172
Molecular Function	GO:0035612	AP-2 adaptor complex binding	LDLRAP1	IDA		Human	PMID:12451172
Molecular Function	GO:0035612	AP-2 adaptor complex binding	LDLRAP1	IDA		Human	PMID:15728179
Molecular Function	GO:0035615	clathrin adaptor activity	LDLRAP1	IDA		Human	PMID:15728179
Molecular Function	GO:0030276	clathrin binding	LDLRAP1	IDA		Human	PMID:12221107
Molecular Function	GO:0030276	clathrin binding	LDLRAP1	IDA		Human	PMID:12451172
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	LDLRAP1	IPI	UniProtKB:P01130	Human	PMID:12221107
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	LDLRAP1	IPI	UniProtKB:P98158	Human	PMID:14528014
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	LDLRAP1	IDA		Human	PMID:12451172
Molecular Function	GO:0001784	phosphotyrosine residue binding	LDLRAP1	IDA		Human	PMID:12451172
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P63010	Human	PMID:12221107
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P63010	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P63010	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q9H668	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q8NDX1-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q9H668	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P63010-2	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q9UPT6	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q9H668	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:A8MTQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P13378	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P31273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P43358	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P63010-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q02548	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q10567-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q14192	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q6ZVH7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q8NDX1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q9H668	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:Q9UPT6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LDLRAP1	IPI	UniProtKB:P63010	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Ldlrap1	IPI	UniProtKB:Q03157|UniProtKB:Q8R3R8|UniProtKB:Q91ZX7	Mouse	MGI:MGI:3762243|PMID:17727637
Molecular Function	GO:0005515	protein binding	Ldlrap1	IPI	PR:P35951	Mouse	PMID:12746448
Molecular Function	GO:0005515	protein binding	Ldlrap1	IPI	UniProtKB:P98158:PRO_0000017322	Rat	PMID:14528014|RGD:8553370
Molecular Function	GO:0005515	protein binding	Ldlrap1	IPI	UniProtKB:P01130	Rat	PMID:22509010|RGD:13432257
Molecular Function	GO:0035591	signaling adaptor activity	LDLRAP1	IDA		Human	PMID:12221107
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	LDLRAP1	IMP		Human	PMID:15166224
Cellular Component	GO:0030424	axon	Ldlrap1	IDA		Rat	PMID:17727637|RGD:8553450
Cellular Component	GO:0009925	basal plasma membrane	LDLRAP1	IDA		Human	PMID:12451172
Cellular Component	GO:0005737	cytoplasm	Ldlrap1	IDA		Mouse	MGI:MGI:3762243|PMID:17727637
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	LDLRAP1	IDA		Human	PMID:14528014
Cellular Component	GO:0005829	cytosol	LDLRAP1	IDA		Human	PMID:12451172
Cellular Component	GO:0005769	early endosome	LDLRAP1	IDA		Human	PMID:14528014
Cellular Component	GO:0005769	early endosome	Ldlrap1	IDA		Mouse	PMID:12746448
Cellular Component	GO:0005883	neurofilament	Ldlrap1	IDA		Mouse	MGI:MGI:3762243|PMID:17727637
Cellular Component	GO:0055037	recycling endosome	LDLRAP1	IDA		Human	PMID:14528014
Biological Process	GO:0042982	amyloid precursor protein metabolic process	LDLRAP1	IMP		Human	PMID:12805363
Biological Process	GO:0071345	cellular response to cytokine stimulus	LDLRAP1	IMP		Human	PMID:28257760
Biological Process	GO:0042632	cholesterol homeostasis	LDLRAP1	IMP		Human	PMID:15166224
Biological Process	GO:0042632	cholesterol homeostasis	Ldlrap1	IMP	MGI:MGI:2670480	Mouse	PMID:12746448
Biological Process	GO:0034383	low-density lipoprotein particle clearance	LDLRAP1	IMP		Human	PMID:12417523
Biological Process	GO:0034383	low-density lipoprotein particle clearance	LDLRAP1	IMP		Human	PMID:12464675
Biological Process	GO:0034383	low-density lipoprotein particle clearance	LDLRAP1	IMP		Human	PMID:15166224
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance	LDLRAP1	IMP		Human	PMID:28257760
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	LDLRAP1	IMP		Human	PMID:15166224
Biological Process	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	LDLRAP1	IMP		Human	PMID:12417523
Biological Process	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	LDLRAP1	IMP		Human	PMID:12464675
Biological Process	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	LDLRAP1	IMP		Human	PMID:15166224
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	LDLRAP1	IMP		Human	PMID:28257760
Biological Process	GO:0031623	receptor internalization	LDLRAP1	IMP		Human	PMID:15166224
Biological Process	GO:0006898	receptor-mediated endocytosis	LDLRAP1	IDA		Human	PMID:14528014
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	LDLRAP1	IMP		Human	PMID:12417523
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	LDLRAP1	IMP		Human	PMID:12464675
Biological Process	GO:0090118	receptor-mediated endocytosis involved in cholesterol transport	LDLRAP1	IMP		Human	PMID:15166224
Biological Process	GO:0043393	regulation of protein binding	LDLRAP1	IMP		Human	PMID:15166224
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	LDLRAP1	IMP		Human	PMID:12805363

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern