Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LEP
  • Mouse genes Lep
  • Rat genes Lep
  • Zfish genes lepa,lepb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lep

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Lep	IDA		Mouse	PMID:29519872
Molecular Function	GO:0008083	growth factor activity	Lep	IDA		Mouse	PMID:9057630
Molecular Function	GO:0005179	hormone activity	Lep	IDA		Rat	PMID:9070213|RGD:2290293
Molecular Function	GO:1990460	leptin receptor binding	LEP	IDA		Human	PMID:27037668
Molecular Function	GO:0051428	peptide hormone receptor binding	Lep	IDA		Rat	PMID:9070213|RGD:2290293
Molecular Function	GO:0005515	protein binding	LEP	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Lep	IPI	UniProtKB:P48356	Mouse	MGI:MGI:5926187|PMID:24882746
Molecular Function	GO:0005515	protein binding	Lep	IPI	UniProtKB:P98158	Rat	PMID:17324488|RGD:13210549
Molecular Function	GO:0005102	signaling receptor binding	Lep	IPI	RGD:68407	Rat	PMID:15131016|RGD:10053635
Cellular Component	GO:0005737	cytoplasm	Lep	IDA		Mouse	MGI:MGI:5486574|PMID:11387233
Cellular Component	GO:0005829	cytosol	Lep	IDA		Rat	PMID:17324488|RGD:13210549
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Mouse	MGI:MGI:5486574|PMID:11387233
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Mouse	MGI:MGI:1203479|PMID:9590691
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Mouse	PMID:20952387
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Mouse	PMID:17693256
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Mouse	PMID:12540600
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Rat	PMID:21060836|RGD:10053619
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Rat	PMID:25943649|RGD:152995488
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Rat	PMID:29089335|RGD:21410183
Cellular Component	GO:0005615	extracellular space	Lep	IDA		Rat	PMID:9590691|RGD:8554847
Biological Process	GO:1990051	activation of protein kinase C activity	LEP	IDA		Human	PMID:24340098
Biological Process	GO:0060612	adipose tissue development	Lep	IGI	MGI:MGI:101761	Mouse	PMID:10742101
Biological Process	GO:0008343	adult feeding behavior	Lep	IDA		Mouse	MGI:MGI:1203479|PMID:9590691
Biological Process	GO:0001525	angiogenesis	LEP	IDA		Human	PMID:19910644
Biological Process	GO:0001525	angiogenesis	LEP	IDA		Human	PMID:21771332
Biological Process	GO:0035904	aorta development	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:23413430
Biological Process	GO:0008206	bile acid metabolic process	Lep	IDA		Mouse	PMID:12114517
Biological Process	GO:0098868	bone growth	Lep	IMP		Mouse	MGI:MGI:1352383|PMID:10660043
Biological Process	GO:0035630	bone mineralization involved in bone maturation	Lep	IDA		Rat	PMID:21353474|RGD:5128507
Biological Process	GO:0043010	camera-type eye development	lepa	IMP	ZFIN:ZDB-MRPHLNO-121019-3	Zfish	PMID:22841760
Biological Process	GO:0003300	cardiac muscle hypertrophy	Lep	IDA		Rat	PMID:20738325|RGD:8693628
Biological Process	GO:0032869	cellular response to insulin stimulus	Lep	IDA		Mouse	PMID:29519872
Biological Process	GO:0071298	cellular response to L-ascorbic acid	Lep	IEP		Rat	PMID:20400526|RGD:5128594
Biological Process	GO:0044320	cellular response to leptin stimulus	LEP	IDA		Human	PMID:17344214
Biological Process	GO:0071300	cellular response to retinoic acid	Lep	IEP		Rat	PMID:19212007|RGD:5128705
Biological Process	GO:0021954	central nervous system neuron development	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:10592285
Biological Process	GO:0008203	cholesterol metabolic process	Lep	IGI	MGI:MGI:88049	Mouse	PMID:15995171
Biological Process	GO:0007623	circadian rhythm	Lep	IEP		Rat	PMID:21164040|RGD:5128545
Biological Process	GO:0008340	determination of adult lifespan	Lep	IGI	MGI:MGI:1328317	Mouse	PMID:28069950
Biological Process	GO:0042755	eating behavior	Lep	IGI	MGI:MGI:98735	Mouse	PMID:10802666
Biological Process	GO:0051541	elastin metabolic process	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:23413430
Biological Process	GO:0006112	energy reserve metabolic process	Lep	IDA		Rat	PMID:12058043|RGD:625499
Biological Process	GO:0006635	fatty acid beta-oxidation	Lep	IGI	MGI:MGI:2651874	Mouse	PMID:22958918
Biological Process	GO:0009062	fatty acid catabolic process	Lep	IDA		Rat	PMID:12058043|RGD:625499
Biological Process	GO:0007565	female pregnancy	Lep	IEP		Rat	PMID:21303957|RGD:6480202
Biological Process	GO:0042593	glucose homeostasis	Lep	IGI	MGI:MGI:2651874	Mouse	PMID:22958918
Biological Process	GO:0042593	glucose homeostasis	lepb	IMP	ZFIN:ZDB-GENO-220412-2	Zfish	PMID:33705349
Biological Process	GO:0042593	glucose homeostasis	lepb	IMP	ZFIN:ZDB-GENO-220412-1	Zfish	PMID:33705349
Biological Process	GO:0006006	glucose metabolic process	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:12540600
Biological Process	GO:0006114	glycerol biosynthetic process	Lep	IDA		Rat	PMID:21068181|RGD:5128556
Biological Process	GO:0042445	hormone metabolic process	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:16513828
Biological Process	GO:0048839	inner ear development	lepa	IMP	ZFIN:ZDB-MRPHLNO-121019-3	Zfish	PMID:22841760
Biological Process	GO:0030073	insulin secretion	Lep	IGI	MGI:MGI:1343180	Mouse	PMID:16141392
Biological Process	GO:0050892	intestinal absorption	LEP	IDA		Human	PMID:24340098
Biological Process	GO:0035556	intracellular signal transduction	Lep	IDA		Rat	PMID:12130569|RGD:625717
Biological Process	GO:0033210	leptin-mediated signaling pathway	Lep	IDA		Mouse	MGI:MGI:5700303|PMID:16825198
Biological Process	GO:0033210	leptin-mediated signaling pathway	Lep	IDA		Rat	PMID:11677594|RGD:10448951
Biological Process	GO:0033210	leptin-mediated signaling pathway	Lep	IDA		Rat	PMID:9070213|RGD:2290293
Biological Process	GO:0033210	leptin-mediated signaling pathway	Lep	IDA		Rat	PMID:9618284|RGD:2290294
Biological Process	GO:0050901	leukocyte tethering or rolling	Lep	IDA		Rat	PMID:20150963|RGD:5128596
Biological Process	GO:0006629	lipid metabolic process	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:12815040
Biological Process	GO:0006629	lipid metabolic process	Lep	IEP		Rat	PMID:29089335|RGD:21410183
Biological Process	GO:0043066	negative regulation of apoptotic process	Lep	IDA		Rat	PMID:19730157|RGD:5128624
Biological Process	GO:0032099	negative regulation of appetite	Lep	IDA		Mouse	MGI:MGI:1203479|PMID:9590691
Biological Process	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	Lep	IDA		Rat	PMID:11677594|RGD:10448951
Biological Process	GO:0010507	negative regulation of autophagy	LEP	IDA		Human	PMID:25060689
Biological Process	GO:0010507	negative regulation of autophagy	Lep	IMP		Mouse	MGI:MGI:5705211|PMID:25060689
Biological Process	GO:0061037	negative regulation of cartilage development	Lep	IDA		Rat	PMID:19876764|RGD:5128612
Biological Process	GO:0070093	negative regulation of glucagon secretion	Lep	IDA		Mouse	MGI:MGI:4889014|PMID:21234744
Biological Process	GO:0046325	negative regulation of glucose import	LEP	IDA		Human	PMID:24340098
Biological Process	GO:2000486	negative regulation of glutamine transport	Lep	IMP		Rat	PMID:20448142|RGD:5128592
Biological Process	GO:0010888	negative regulation of lipid storage	Lep	IDA		Rat	PMID:17024416|RGD:10053573
Biological Process	GO:0009892	negative regulation of metabolic process	Lep	IDA		Rat	PMID:12130569|RGD:625717
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Lep	IDA		Mouse	MGI:MGI:4889014|PMID:21234744
Biological Process	GO:0045906	negative regulation of vasoconstriction	Lep	IDA		Rat	PMID:20978518|RGD:5128573
Biological Process	GO:0007399	nervous system development	lepa	IMP	ZFIN:ZDB-MRPHLNO-121019-3	Zfish	PMID:22841760
Biological Process	GO:0001542	ovulation from ovarian follicle	Lep	IDA		Rat	PMID:17071778|RGD:1582677
Biological Process	GO:0006909	phagocytosis	Lep	IDA		Mouse	MGI:MGI:3690675|PMID:9438411
Biological Process	GO:0006909	phagocytosis	Lep	IDA		Rat	PMID:9438411|RGD:11041004
Biological Process	GO:0001890	placenta development	LEP	IDA		Human	PMID:17957153
Biological Process	GO:0008284	positive regulation of cell population proliferation	Lep	IDA		Rat	PMID:18978578|RGD:5128722
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Lep	IMP		Mouse	MGI:MGI:6101136|PMID:27986616
Biological Process	GO:0001819	positive regulation of cytokine production	Lep	IEP		Rat	PMID:19922787|RGD:5128608
Biological Process	GO:0048639	positive regulation of developmental growth	LEP	IDA		Human	PMID:17957153
Biological Process	GO:1904651	positive regulation of fat cell apoptotic process	Lep	IDA		Rat	PMID:17024416|RGD:10053573
Biological Process	GO:0046881	positive regulation of follicle-stimulating hormone secretion	Lep	IEP		Rat	PMID:19112389|RGD:5128709
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	Lep	IDA		Rat	PMID:19299451|RGD:5128574
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Lep	IDA		Rat	PMID:20977462|RGD:5128575
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Lep	IDA		Mouse	MGI:MGI:3690675|PMID:9438411
Biological Process	GO:0032755	positive regulation of interleukin-6 production	LEP	IDA		Human	PMID:19688109
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Lep	IDA		Mouse	MGI:MGI:3690675|PMID:9438411
Biological Process	GO:0032757	positive regulation of interleukin-8 production	LEP	IDA		Human	PMID:19688109
Biological Process	GO:0033686	positive regulation of luteinizing hormone secretion	Lep	IEP		Rat	PMID:19112389|RGD:5128709
Biological Process	GO:0043410	positive regulation of MAPK cascade	LEP	IDA		Human	PMID:24340098
Biological Process	GO:0043410	positive regulation of MAPK cascade	Lep	IDA		Mouse	MGI:MGI:5700303|PMID:16825198
Biological Process	GO:0043410	positive regulation of MAPK cascade	Lep	IDA		Rat	PMID:9618284|RGD:2290294
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	Lep	IDA		Rat	PMID:20203064|RGD:5128595
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	Lep	IDA		Mouse	PMID:9057630
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	LEP	IDA		Human	PMID:24340098
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	Lep	IDA		Rat	PMID:20738325|RGD:8693628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	LEP	IDA		Human	PMID:24340098
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Lep	IDA		Mouse	MGI:MGI:4821191|PMID:20620997
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Lep	IDA		Rat	PMID:11677594|RGD:10448951
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Lep	IDA		Mouse	MGI:MGI:4889014|PMID:21234744
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Lep	IDA		Mouse	MGI:MGI:5700303|PMID:16825198
Biological Process	GO:0001934	positive regulation of protein phosphorylation	LEP	IDA		Human	PMID:27037668
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Lep	IDA		Rat	PMID:20738325|RGD:8693628
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	LEP	IDA		Human	PMID:17344214
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Lep	IDA		Mouse	MGI:MGI:5700303|PMID:16825198
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Lep	IDA		Mouse	MGI:MGI:4889014|PMID:21234744
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Lep	IMP		Rat	PMID:21250909|RGD:5128518
Biological Process	GO:0042102	positive regulation of T cell proliferation	LEP	IDA		Human	PMID:25060689
Biological Process	GO:0032008	positive regulation of TOR signaling	LEP	IDA		Human	PMID:25060689
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Lep	IDA		Mouse	MGI:MGI:3690675|PMID:9438411
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Lep	IMP		Rat	PMID:19726711|RGD:5128629
Biological Process	GO:0032310	prostaglandin secretion	LEP	IDA		Human	PMID:19688109
Biological Process	GO:0045765	regulation of angiogenesis	LEP	IDA		Human	PMID:11460888
Biological Process	GO:0008217	regulation of blood pressure	Lep	IDA		Rat	PMID:20059648|RGD:5128597
Biological Process	GO:0046850	regulation of bone remodeling	Lep	IMP		Mouse	MGI:MGI:1352383|PMID:10660043
Biological Process	GO:0090335	regulation of brown fat cell differentiation	Lep	IDA		Mouse	MGI:MGI:4821191|PMID:20620997
Biological Process	GO:0050790	regulation of catalytic activity	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:23413430
Biological Process	GO:0051726	regulation of cell cycle	LEP	IDA		Human	PMID:17344214
Biological Process	GO:0051726	regulation of cell cycle	Lep	IDA		Mouse	MGI:MGI:5700303|PMID:16825198
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	LEP	IDA		Human	PMID:19688109
Biological Process	GO:0001936	regulation of endothelial cell proliferation	LEP	IDA		Human	PMID:11460888
Biological Process	GO:0045598	regulation of fat cell differentiation	Lep	IGI	MGI:MGI:2652843	Mouse	PMID:22927639
Biological Process	GO:0006111	regulation of gluconeogenesis	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:16513828
Biological Process	GO:0010906	regulation of glucose metabolic process	lepb	IMP	ZFIN:ZDB-GENO-220412-2	Zfish	PMID:33705349
Biological Process	GO:0010906	regulation of glucose metabolic process	lepb	IMP	ZFIN:ZDB-GENO-220412-1	Zfish	PMID:33705349
Biological Process	GO:0050796	regulation of insulin secretion	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:16513828
Biological Process	GO:0030300	regulation of intestinal cholesterol absorption	Lep	IDA		Mouse	PMID:12114517
Biological Process	GO:0046890	regulation of lipid biosynthetic process	Lep	IGI	MGI:MGI:1328317	Mouse	PMID:28069950
Biological Process	GO:0019216	regulation of lipid metabolic process	lepb	IMP	ZFIN:ZDB-GENO-220412-1	Zfish	PMID:33705349
Biological Process	GO:0019216	regulation of lipid metabolic process	lepb	IMP	ZFIN:ZDB-GENO-220412-2	Zfish	PMID:33705349
Biological Process	GO:0060587	regulation of lipoprotein lipid oxidation	Lep	IDA		Rat	PMID:21068181|RGD:5128556
Biological Process	GO:0019222	regulation of metabolic process	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:12925742
Biological Process	GO:0032814	regulation of natural killer cell activation	LEP	IDA		Human	PMID:12504075
Biological Process	GO:0042269	regulation of natural killer cell mediated cytotoxicity	LEP	IDA		Human	PMID:12504075
Biological Process	GO:0032817	regulation of natural killer cell proliferation	LEP	IDA		Human	PMID:12504075
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	LEP	IDA		Human	PMID:15899045
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	Lep	IDA		Mouse	MGI:MGI:5705224|PMID:15899045
Biological Process	GO:1900180	regulation of protein localization to nucleus	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:20541607
Biological Process	GO:0001932	regulation of protein phosphorylation	Lep	IDA		Mouse	MGI:MGI:4889014|PMID:21234744
Biological Process	GO:0050810	regulation of steroid biosynthetic process	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:16513828
Biological Process	GO:0014823	response to activity	Lep	IEP		Rat	PMID:23178146|RGD:10053641
Biological Process	GO:0002021	response to dietary excess	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:16141392
Biological Process	GO:0002021	response to dietary excess	Lep	IGI	MGI:MGI:1343180	Mouse	PMID:12177191
Biological Process	GO:0002021	response to dietary excess	Lep	IMP		Rat	PMID:19726711|RGD:5128629
Biological Process	GO:0032355	response to estradiol	Lep	IEP		Rat	PMID:12412816|RGD:10053624
Biological Process	GO:0045471	response to ethanol	Lep	IEP		Rat	PMID:23380443|RGD:10053623
Biological Process	GO:0045471	response to ethanol	Lep	IEP		Rat	PMID:29089335|RGD:21410183
Biological Process	GO:0001666	response to hypoxia	Lep	IEP		Rat	PMID:15284063|RGD:5129123
Biological Process	GO:0032868	response to insulin	Lep	IMP	MGI:MGI:1856424	Mouse	PMID:16141392
Biological Process	GO:0007584	response to nutrient	Lep	IEP		Rat	PMID:15616803|RGD:1581835
Biological Process	GO:0007584	response to nutrient	Lep	IEP		Rat	PMID:29089335|RGD:21410183
Biological Process	GO:0031667	response to nutrient levels	Lep	IEP		Rat	PMID:21060836|RGD:10053619
Biological Process	GO:0031667	response to nutrient levels	Lep	IEP		Rat	PMID:25943649|RGD:152995488
Biological Process	GO:0042594	response to starvation	lepb	IDA		Zfish	PMID:19293295
Biological Process	GO:0033197	response to vitamin E	Lep	IEP		Rat	PMID:20404018|RGD:5128593
Biological Process	GO:0019953	sexual reproduction	LEP	IMP		Human	PMID:8589726
Biological Process	GO:0019953	sexual reproduction	Lep	IMP		Mouse	MGI:MGI:79247|PMID:8589726
Biological Process	GO:0030217	T cell differentiation	Lep	IMP		Mouse	MGI:MGI:1277764|PMID:9732873
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Lep	IDA		Mouse	MGI:MGI:4889014|PMID:21234744

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern