Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lepr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LEPR
- Mouse genes Lepr
- Rat genes Lepr
- Zfish genes lepr
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lepr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038021	leptin receptor activity	LEPR	IDA		Human	PMID:20977476
Molecular Function	GO:0038021	leptin receptor activity	LEPR	IDA		Human	PMID:27037668
Molecular Function	GO:0038021	leptin receptor activity	Lepr	IMP		Mouse	MGI:MGI:2652302\|PMID:12594516
Molecular Function	GO:0017046	peptide hormone binding	Lepr	IDA		Rat	PMID:17023527\|RGD:1600765
Molecular Function	GO:0017046	peptide hormone binding	Lepr	IMP		Rat	PMID:17023527\|RGD:1600765
Molecular Function	GO:0017046	peptide hormone binding	Lepr	IDA		Rat	PMID:9070213\|RGD:2290293
Molecular Function	GO:0005515	protein binding	LEPR	IPI	UniProtKB:Q9UNH7	Human	PMID:11279102
Molecular Function	GO:0005515	protein binding	LEPR	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	LEPR	IPI	UniProtKB:O15243	Human	PMID:18042720
Molecular Function	GO:0005515	protein binding	LEPR	IPI	UniProtKB:P12931,UniProtKB:P18084	Human	PMID:19910644
Molecular Function	GO:0005515	protein binding	Lepr	IPI	UniProtKB:Q62077	Mouse	MGI:MGI:3629374\|PMID:16698021
Molecular Function	GO:0005515	protein binding	Lepr	IPI	UniProtKB:P41160	Mouse	MGI:MGI:5926187\|PMID:24882746
Molecular Function	GO:0005515	protein binding	Lepr	IPI	UniProtKB:Q62120\|UniProtKB:Q91ZX7	Mouse	MGI:MGI:4944032\|PMID:21264353
Molecular Function	GO:0005515	protein binding	Lepr	IPI	PR:Q3V3N7	Mouse	PMID:19150989
Molecular Function	GO:0016500	protein-hormone receptor activity	Lepr	IDA		Rat	PMID:17023527\|RGD:1600765
Molecular Function	GO:0016500	protein-hormone receptor activity	Lepr	IMP		Rat	PMID:17023527\|RGD:1600765
Molecular Function	GO:0016500	protein-hormone receptor activity	Lepr	IDA		Rat	PMID:9070213\|RGD:2290293
Cellular Component	GO:0005615	extracellular space	Lepr	IDA		Rat	PMID:16037380\|RGD:1581831
Cellular Component	GO:0005886	plasma membrane	Lepr	IDA		Rat	PMID:16037380\|RGD:1581831
Cellular Component	GO:0043235	receptor complex	LEPR	IDA		Human	PMID:23382219
Biological Process	GO:0007568	aging	Lepr	IEP		Rat	PMID:14615055\|RGD:10412035
Biological Process	GO:0001525	angiogenesis	LEPR	IMP		Human	PMID:21771332
Biological Process	GO:0001525	angiogenesis	Lepr	IMP		Rat	PMID:12393625\|RGD:729241
Biological Process	GO:0098868	bone growth	Lepr	IMP		Mouse	MGI:MGI:1352383\|PMID:10660043
Biological Process	GO:0043010	camera-type eye development	lepr	IMP	ZFIN:ZDB-MRPHLNO-121019-6	Zfish	PMID:22841760
Biological Process	GO:0071310	cellular response to organic substance	Lepr	IEP		Rat	PMID:12928006\|RGD:1581851
Biological Process	GO:0008203	cholesterol metabolic process	Lepr	IGI	MGI:MGI:88049	Mouse	PMID:15995171
Biological Process	GO:0042755	eating behavior	Lepr	IMP		Rat	PMID:12824696\|RGD:1581839
Biological Process	GO:0097009	energy homeostasis	Lepr	IMP		Mouse	MGI:MGI:5621105\|PMID:25383904
Biological Process	GO:0097009	energy homeostasis	Lepr	IMP		Mouse	MGI:MGI:2652302\|PMID:12594516
Biological Process	GO:0007565	female pregnancy	Lepr	IEP		Rat	PMID:12297537\|RGD:10412034
Biological Process	GO:0007565	female pregnancy	Lepr	IEP		Rat	PMID:15905318\|RGD:1581833
Biological Process	GO:0014009	glial cell proliferation	Lepr	IGI	MGI:MGI:1341085	Mouse	PMID:28973665
Biological Process	GO:0006094	gluconeogenesis	Lepr	IMP	MGI:MGI:1856009	Mouse	PMID:24051374
Biological Process	GO:0042593	glucose homeostasis	Lepr	IMP		Mouse	MGI:MGI:5621105\|PMID:25383904
Biological Process	GO:0042593	glucose homeostasis	Lepr	IMP		Mouse	MGI:MGI:2652302\|PMID:12594516
Biological Process	GO:0005977	glycogen metabolic process	Lepr	IGI	MGI:MGI:1341085	Mouse	PMID:28973665
Biological Process	GO:0048839	inner ear development	lepr	IMP	ZFIN:ZDB-MRPHLNO-121019-6	Zfish	PMID:22841760
Biological Process	GO:0033210	leptin-mediated signaling pathway	LEPR	IDA		Human	PMID:27037668
Biological Process	GO:0033210	leptin-mediated signaling pathway	Lepr	IMP		Mouse	MGI:MGI:2652302\|PMID:12594516
Biological Process	GO:0033210	leptin-mediated signaling pathway	Lepr	IDA		Rat	PMID:9070213\|RGD:2290293
Biological Process	GO:0033210	leptin-mediated signaling pathway	Lepr	IDA		Rat	PMID:9618284\|RGD:2290294
Biological Process	GO:0008584	male gonad development	Lepr	IEP		Rat	PMID:11159367\|RGD:10412037
Biological Process	GO:0010507	negative regulation of autophagy	LEPR	IDA		Human	PMID:25060689
Biological Process	GO:1903999	negative regulation of eating behavior	Lepr	IMP		Rat	PMID:16982424\|RGD:10412019
Biological Process	GO:0045721	negative regulation of gluconeogenesis	Lepr	IMP	MGI:MGI:1856009	Mouse	PMID:24051374
Biological Process	GO:0051346	negative regulation of hydrolase activity	Lepr	IGI	MGI:MGI:88049	Mouse	PMID:15995171
Biological Process	GO:1904060	negative regulation of locomotor rhythm	Lepr	IMP		Rat	PMID:16982424\|RGD:10412019
Biological Process	GO:0007399	nervous system development	lepr	IMP	ZFIN:ZDB-MRPHLNO-121019-6	Zfish	PMID:22841760
Biological Process	GO:0001556	oocyte maturation	lepr	IMP	ZFIN:ZDB-GENO-221019-2	Zfish	PMID:35139421
Biological Process	GO:0030728	ovulation	lepr	IMP	ZFIN:ZDB-GENO-221019-2	Zfish	PMID:35139421
Biological Process	GO:0001542	ovulation from ovarian follicle	Lepr	IEP		Rat	PMID:12959975\|RGD:1582680
Biological Process	GO:0006909	phagocytosis	Lepr	IMP		Mouse	MGI:MGI:3690675\|PMID:9438411
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Lepr	IMP		Mouse	MGI:MGI:1913227\|PMID:11003997
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Lepr	IDA		Rat	PMID:9751766\|RGD:10412039
Biological Process	GO:0043410	positive regulation of MAPK cascade	Lepr	IDA		Rat	PMID:9618284\|RGD:2290294
Biological Process	GO:0001934	positive regulation of protein phosphorylation	LEPR	IDA		Human	PMID:27037668
Biological Process	GO:0046850	regulation of bone remodeling	Lepr	IMP		Mouse	MGI:MGI:1352383\|PMID:10660043
Biological Process	GO:0060259	regulation of feeding behavior	Lepr	IMP		Mouse	MGI:MGI:2652302\|PMID:12594516
Biological Process	GO:0051049	regulation of transport	LEPR	IDA		Human	PMID:20977476
Biological Process	GO:0071548	response to dexamethasone	Lepr	IEP		Rat	PMID:12297537\|RGD:10412034
Biological Process	GO:0043627	response to estrogen	Lepr	IEP		Rat	PMID:15059958\|RGD:1581837
Biological Process	GO:0009749	response to glucose	lepr	IMP	ZFIN:ZDB-GENO-170615-1	Zfish	PMID:26903647
Biological Process	GO:0001666	response to hypoxia	Lepr	IEP		Rat	PMID:15284063\|RGD:5129123
Biological Process	GO:0044321	response to leptin	Lepr	IMP		Mouse	MGI:MGI:2652302\|PMID:12594516
Biological Process	GO:0044321	response to leptin	Lepr	IEP		Rat	PMID:18515494\|RGD:5129110
Biological Process	GO:0033993	response to lipid	Lepr	IEP		Rat	PMID:9751212\|RGD:10412024
Biological Process	GO:0035094	response to nicotine	Lepr	IEP		Rat	PMID:12576193\|RGD:1581840
Biological Process	GO:0007584	response to nutrient	Lepr	IEP		Rat	PMID:18755573\|RGD:5129092
Biological Process	GO:0019953	sexual reproduction	Lepr	IMP		Mouse	MGI:MGI:2652302\|PMID:12594516
Biological Process	GO:0030217	T cell differentiation	Lepr	IMP		Mouse	MGI:MGI:1277764\|PMID:9732873
Biological Process	GO:0003323	type B pancreatic cell development	lepr	IMP	ZFIN:ZDB-GENO-170615-1	Zfish	PMID:26903647
Biological Process	GO:0042060	wound healing	Lepr	IEP		Rat	PMID:22773832\|RGD:10412021

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.