Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LGALS9,LGALS9B,LGALS9C
  • Mouse genes Lgals9
  • Rat genes Lgals5,Lgals9
  • Zfish genes lgals9l1,lgals9l3,lgals9l4,lgals9l5,lgals9l6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lgals9

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030246	carbohydrate binding	LGALS9	IDA		Human	PMID:18977853
Molecular Function	GO:0030246	carbohydrate binding	Lgals9	IMP		Mouse	MGI:MGI:5014432|PMID:21670307
Molecular Function	GO:0030246	carbohydrate binding	Lgals9	IDA		Mouse	MGI:MGI:5644014|PMID:23242525
Molecular Function	GO:0048030	disaccharide binding	LGALS9	IMP		Human	PMID:16116184
Molecular Function	GO:0019899	enzyme binding	LGALS9	IPI	UniProtKB:P07237,UniProtKB:P30101,UniProtKB:Q15084	Human	PMID:21670307
Molecular Function	GO:0019899	enzyme binding	Lgals9	IPI	UniProtKB:P09103	Mouse	MGI:MGI:5014432|PMID:21670307
Molecular Function	GO:0016936	galactoside binding	Lgals9	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:O00308	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:O75553	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:Q9NRG1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:O00308	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:O00308	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:P47897	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:Q17RB8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:Q8N5M1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS9B	IPI	UniProtKB:Q9NYB9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:O15162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:O75553	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P47897	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:O14645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P00488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P02489	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P06307	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P19404	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P29474	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q14204	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q86V38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q9BVL2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS9C	IPI	UniProtKB:Q9Y5Z0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Lgals9	IPI	UniProtKB:P15379	Mouse	MGI:MGI:5688819|PMID:25065622
Molecular Function	GO:0005515	protein binding	Lgals9	IPI	UniProtKB:Q8VIM0	Mouse	MGI:MGI:3662972|PMID:16286920
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Lgals9	IDA		Mouse	MGI:MGI:5688819|PMID:25065622
Molecular Function	GO:0005102	signaling receptor binding	Lgals9	IPI	UniProtKB:P15379	Mouse	MGI:MGI:5688819|PMID:25065622
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS9	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Lgals9	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	LGALS9	IDA		Human	PMID:23242525
Cellular Component	GO:0005737	cytoplasm	Lgals9	IDA		Mouse	MGI:MGI:5644014|PMID:23242525
Cellular Component	GO:0005829	cytosol	LGALS9	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	LGALS9B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	LGALS9C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	LGALS9	IDA		Human	PMID:20209097
Cellular Component	GO:0005634	nucleus	LGALS9	IDA		Human	PMID:23242525
Cellular Component	GO:0005634	nucleus	Lgals9	IDA		Mouse	MGI:MGI:5644014|PMID:23242525
Biological Process	GO:0071346	cellular response to type II interferon	LGALS9	IDA		Human	PMID:23817958
Biological Process	GO:0098586	cellular response to virus	LGALS9	IMP		Human	PMID:25754930
Biological Process	GO:0098586	cellular response to virus	Lgals9	IMP		Mouse	MGI:MGI:5491117|PMID:23408620
Biological Process	GO:0070371	ERK1 and ERK2 cascade	LGALS9	IDA		Human	PMID:16116184
Biological Process	GO:0007565	female pregnancy	LGALS9	IDA		Human	PMID:23242525
Biological Process	GO:0007565	female pregnancy	Lgals9	IDA		Mouse	MGI:MGI:5644014|PMID:23242525
Biological Process	GO:0006954	inflammatory response	LGALS9	IDA		Human	PMID:23817958
Biological Process	GO:0045185	maintenance of protein location	Lgals9	IDA		Mouse	MGI:MGI:5014432|PMID:21670307
Biological Process	GO:0060135	maternal process involved in female pregnancy	LGALS9	IDA		Human	PMID:25578313
Biological Process	GO:0002519	natural killer cell tolerance induction	LGALS9	IMP	UniProtKB:Q8TDQ0	Human	PMID:25578313
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	LGALS9	IMP		Human	PMID:23817958
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	Lgals9	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0032682	negative regulation of chemokine production	LGALS9	IMP		Human	PMID:25754930
Biological Process	GO:0010629	negative regulation of gene expression	LGALS9	IDA		Human	PMID:23408620
Biological Process	GO:0010629	negative regulation of gene expression	LGALS9	IMP	UniProtKB:Q8TDQ0	Human	PMID:25578313
Biological Process	GO:0010629	negative regulation of gene expression	Lgals9	IMP		Mouse	MGI:MGI:5491117|PMID:23408620
Biological Process	GO:0050728	negative regulation of inflammatory response	Lgals9	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0043305	negative regulation of mast cell degranulation	LGALS9	IMP		Human	PMID:24465902
Biological Process	GO:0032815	negative regulation of natural killer cell activation	Lgals9	IMP		Mouse	MGI:MGI:5491117|PMID:23408620
Biological Process	GO:0043322	negative regulation of natural killer cell degranulation	Lgals9	IMP		Mouse	MGI:MGI:5491117|PMID:23408620
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	LGALS9	IDA		Human	PMID:23408620
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	LGALS9	IMP	UniProtKB:Q8TDQ0	Human	PMID:25578313
Biological Process	GO:0032689	negative regulation of type II interferon production	LGALS9	IDA		Human	PMID:23408620
Biological Process	GO:0032689	negative regulation of type II interferon production	Lgals9	IDA		Mouse	MGI:MGI:5644014|PMID:23242525
Biological Process	GO:0032689	negative regulation of type II interferon production	Lgals9	IMP		Mouse	MGI:MGI:5491117|PMID:23408620
Biological Process	GO:0038066	p38MAPK cascade	LGALS9	IDA		Human	PMID:16116184
Biological Process	GO:0070241	positive regulation of activated T cell autonomous cell death	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	LGALS9	IDA		Human	PMID:16116184
Biological Process	GO:0032834	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:0032722	positive regulation of chemokine production	Lgals9	IMP	UniProtKB:Q8VIM0	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	LGALS9	IMP		Human	PMID:24465902
Biological Process	GO:0001819	positive regulation of cytokine production	Lgals9	IMP	UniProtKB:Q8VIM0	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:1900426	positive regulation of defense response to bacterium	Lgals9	IMP	UniProtKB:Q8VIM0	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	LGALS9	IDA		Human	PMID:16116184
Biological Process	GO:2000510	positive regulation of dendritic cell chemotaxis	LGALS9	IMP		Human	PMID:25754930
Biological Process	GO:2001200	positive regulation of dendritic cell differentiation	LGALS9	IMP		Human	PMID:16116184
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	LGALS9	IMP		Human	PMID:24465902
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	LGALS9	IMP	UniProtKB:Q99731	Human	PMID:25754930
Biological Process	GO:0010628	positive regulation of gene expression	LGALS9	IDA		Human	PMID:16116184
Biological Process	GO:0010628	positive regulation of gene expression	Lgals9	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	LGALS9	HMP		Human	PMID:12761501
Biological Process	GO:0045089	positive regulation of innate immune response	Lgals9	IMP	UniProtKB:Q8VIM0	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:0032732	positive regulation of interleukin-1 production	Lgals9	IMP	UniProtKB:Q8VIM0	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:0032733	positive regulation of interleukin-10 production	LGALS9	IDA		Human	PMID:16116184
Biological Process	GO:0032733	positive regulation of interleukin-10 production	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Lgals9	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0032735	positive regulation of interleukin-12 production	LGALS9	IMP		Human	PMID:16116184
Biological Process	GO:0032735	positive regulation of interleukin-12 production	LGALS9	IMP		Human	PMID:25754930
Biological Process	GO:0032736	positive regulation of interleukin-13 production	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:0032753	positive regulation of interleukin-4 production	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:0032753	positive regulation of interleukin-4 production	LGALS9	IMP	UniProtKB:Q8VIM0	Human	PMID:25578313
Biological Process	GO:0032755	positive regulation of interleukin-6 production	LGALS9	IMP		Human	PMID:24465902
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Lgals9	IMP		Mouse	MGI:MGI:5645190|PMID:25158758
Biological Process	GO:0032757	positive regulation of interleukin-8 production	LGALS9	IMP		Human	PMID:24465902
Biological Process	GO:0043032	positive regulation of macrophage activation	Lgals9	IMP	UniProtKB:Q8VIM0	Mouse	MGI:MGI:4839671|PMID:20937702
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	LGALS9	IMP		Human	PMID:24465902
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	LGALS9	IMP		Human	PMID:25754930
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	LGALS9	IMP		Human	PMID:25754930
Biological Process	GO:0051353	positive regulation of oxidoreductase activity	Lgals9	IDA		Mouse	MGI:MGI:5014432|PMID:21670307
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	Lgals9	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	Lgals9	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	LGALS9	IDA		Human	PMID:16116184
Biological Process	GO:2000406	positive regulation of T cell migration	Lgals9	IDA		Mouse	MGI:MGI:5014432|PMID:21670307
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	Lgals9	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Lgals9	IMP		Mouse	MGI:MGI:5645190|PMID:25158758
Biological Process	GO:0032729	positive regulation of type II interferon production	LGALS9	IDA		Human	PMID:20209097
Biological Process	GO:0046598	positive regulation of viral entry into host cell	LGALS9	IDA		Human	PMID:21670307
Biological Process	GO:0032823	regulation of natural killer cell differentiation	Lgals9	IMP		Mouse	MGI:MGI:5491117|PMID:23408620
Biological Process	GO:0070555	response to interleukin-1	LGALS9	IDA		Human	PMID:23817958
Biological Process	GO:0032496	response to lipopolysaccharide	LGALS9	IMP		Human	PMID:25578313
Biological Process	GO:0032496	response to lipopolysaccharide	Lgals9	IMP		Mouse	MGI:MGI:5645190|PMID:25158758
Biological Process	GO:0034138	toll-like receptor 3 signaling pathway	Lgals9	IMP		Rat	PMID:25158758|RGD:10054077

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern