Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LGI1
  • Mouse genes Lgi1
  • Rat genes Lgi1
  • Zfish genes lgi1a,lgi1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lgi1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LGI1	IPI	UniProtKB:O75077	Human	PMID:20463223
Molecular Function	GO:0005515	protein binding	LGI1	IPI	UniProtKB:Q9BZR6	Human	PMID:20463223
Molecular Function	GO:0005515	protein binding	LGI1	IPI	UniProtKB:Q9P0K1	Human	PMID:20463223
Molecular Function	GO:0005515	protein binding	LGI1	IPI	UniProtKB:Q9P0K1	Human	PMID:27066583
Molecular Function	GO:0005515	protein binding	Lgi1	IPI	UniProtKB:Q9R1V6	Mouse	MGI:MGI:4365335|PMID:18974846
Molecular Function	GO:0005515	protein binding	Lgi1	IPI	UniProtKB:Q9CPW0	Mouse	PMID:25707359
Molecular Function	GO:0005515	protein binding	Lgi1	IPI	UniProtKB:P10499	Rat	PMID:16504945|RGD:8554700
Molecular Function	GO:0005515	protein binding	Lgi1	IPI	UniProtKB:P15385	Rat	PMID:16504945|RGD:8554700
Molecular Function	GO:0005515	protein binding	Lgi1	IPI	UniProtKB:P63144	Rat	PMID:16504945|RGD:8554700
Molecular Function	GO:0005515	protein binding	Lgi1	IPI	UniProtKB:P31016	Rat	PMID:16990550|RGD:8553375
Molecular Function	GO:0005515	protein binding	Lgi1	IPI	UniProtKB:Q9R1V6	Rat	PMID:16990550|RGD:8553375
Molecular Function	GO:0005515	protein binding	Lgi1	IPI	UniProtKB:Q9R1V7	Rat	PMID:16990550|RGD:8553375
Molecular Function	GO:0005102	signaling receptor binding	LGI1	IPI	UniProtKB:Q9BZR6	Human	PMID:20463223
Cellular Component	GO:0043194	axon initial segment	Lgi1	IDA		Rat	PMID:30598502|RGD:153298976
Cellular Component	GO:0005737	cytoplasm	Lgi1	IDA		Mouse	MGI:MGI:5695673|PMID:26269648
Cellular Component	GO:0030425	dendrite	Lgi1	IDA		Rat	PMID:30598502|RGD:153298976
Cellular Component	GO:0005615	extracellular space	Lgi1	IDA		Mouse	MGI:MGI:4362010|PMID:15857855
Cellular Component	GO:0005615	extracellular space	Lgi1	IDA		Rat	PMID:16990550|RGD:8553375
Cellular Component	GO:0005615	extracellular space	Lgi1	IDA		Rat	PMID:22589250|RGD:12792971
Cellular Component	GO:0098978	glutamatergic synapse	Lgi1	IDA		Mouse	PMID:20133599
Cellular Component	GO:0098978	glutamatergic synapse	Lgi1	IMP		Mouse	PMID:20133599
Cellular Component	GO:0045202	synapse	Lgi1	IDA		Rat	PMID:22589250|RGD:12792971
Cellular Component	GO:0045202	synapse	Lgi1	IDA		Rat	PMID:30598502|RGD:153298976
Cellular Component	GO:0043083	synaptic cleft	Lgi1	IDA		Mouse	PMID:20133599
Biological Process	GO:0007411	axon guidance	LGI1	IMP		Human	PMID:20463223
Biological Process	GO:0007420	brain development	lgi1a	IMP	ZFIN:ZDB-MRPHLNO-101118-2	Zfish	PMID:20819949
Biological Process	GO:0048854	brain morphogenesis	lgi1b	IMP	ZFIN:ZDB-MRPHLNO-111206-1	Zfish	PMID:22053218
Biological Process	GO:0007626	locomotory behavior	lgi1a	IMP	ZFIN:ZDB-MRPHLNO-101118-1	Zfish	PMID:20819949
Biological Process	GO:0007626	locomotory behavior	lgi1a	IMP	ZFIN:ZDB-MRPHLNO-101118-2	Zfish	PMID:20819949
Biological Process	GO:0042552	myelination	lgi1a	IDA		Zfish	PMID:24715463
Biological Process	GO:0042552	myelination	lgi1b	IDA		Zfish	PMID:24715463
Biological Process	GO:0031175	neuron projection development	LGI1	IMP		Human	PMID:20463223
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	Lgi1	IMP		Mouse	PMID:20133599
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	Lgi1	IDA		Mouse	PMID:20133599
Biological Process	GO:0030307	positive regulation of cell growth	LGI1	IMP		Human	PMID:20463223
Biological Process	GO:0050806	positive regulation of synaptic transmission	Lgi1	IDA		Rat	PMID:16990550|RGD:8553375

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern