Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LGR4
  • Mouse genes Lgr4
  • Rat genes Lgr4
  • Zfish genes lgr4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lgr4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LGR4	IPI	UniProtKB:Q2MKA7	Human	PMID:21727895
Molecular Function	GO:0005515	protein binding	LGR4	IPI	UniProtKB:Q9ULT6	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	LGR4	IPI	UniProtKB:Q2MKA7	Human	PMID:22815884
Molecular Function	GO:0005515	protein binding	Lgr4	IPI	UniProtKB:Q9Z132	Mouse	MGI:MGI:5499719|PMID:21693646
Molecular Function	GO:0004888	transmembrane signaling receptor activity	LGR4	IDA		Human	PMID:21727895
Molecular Function	GO:0004888	transmembrane signaling receptor activity	LGR4	IDA		Human	PMID:22815884
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Lgr4	IDA		Mouse	MGI:MGI:5499719|PMID:21693646
Cellular Component	GO:0005886	plasma membrane	LGR4	IDA		Human	PMID:22815884
Cellular Component	GO:0005886	plasma membrane	Lgr4	IDA		Mouse	MGI:MGI:5499719|PMID:21693646
Biological Process	GO:0030282	bone mineralization	Lgr4	IMP		Mouse	MGI:MGI:4360132|PMID:19605502
Biological Process	GO:0046849	bone remodeling	Lgr4	IMP		Mouse	MGI:MGI:4360132|PMID:19605502
Biological Process	GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development	Lgr4	IMP		Mouse	MGI:MGI:5006869|PMID:21523854
Biological Process	GO:0072202	cell differentiation involved in metanephros development	Lgr4	IMP		Mouse	MGI:MGI:5006869|PMID:21523854
Biological Process	GO:0032922	circadian regulation of gene expression	Lgr4	IMP		Mouse	MGI:MGI:5607511|PMID:24353284
Biological Process	GO:0007623	circadian rhythm	Lgr4	IEP		Mouse	MGI:MGI:5607511|PMID:24353284
Biological Process	GO:0048565	digestive tract development	Lgr4	IMP		Mouse	PMID:24680895
Biological Process	GO:0050673	epithelial cell proliferation	Lgr4	IMP	MGI:MGI:3052121	Mouse	PMID:16406039
Biological Process	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis	Lgr4	IGI	MGI:MGI:1341817	Mouse	PMID:24680895
Biological Process	GO:0001942	hair follicle development	Lgr4	IMP		Mouse	PMID:24680895
Biological Process	GO:0001942	hair follicle development	Lgr4	IGI	MGI:MGI:1341817	Mouse	PMID:24680895
Biological Process	GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron development	lgr4	IMP	ZFIN:ZDB-CRISPR-210115-2,ZFIN:ZDB-CRISPR-210115-3	Zfish	PMID:32493844
Biological Process	GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron development	lgr4	IMP	ZFIN:ZDB-MRPHLNO-210115-2	Zfish	PMID:32493844
Biological Process	GO:0036335	intestinal stem cell homeostasis	Lgr4	IMP		Mouse	PMID:24680895
Biological Process	GO:0030539	male genitalia development	Lgr4	IMP	MGI:MGI:3052121	Mouse	PMID:16406039
Biological Process	GO:0072224	metanephric glomerulus development	Lgr4	IMP		Mouse	MGI:MGI:5006869|PMID:21523854
Biological Process	GO:0072282	metanephric nephron tubule morphogenesis	Lgr4	IMP		Mouse	MGI:MGI:5006869|PMID:21523854
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Lgr4	IMP		Mouse	MGI:MGI:5562618|PMID:24212090
Biological Process	GO:0001818	negative regulation of cytokine production	Lgr4	IMP		Mouse	MGI:MGI:5499954|PMID:23589304
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Lgr4	IMP		Mouse	MGI:MGI:5006869|PMID:21523854
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	Lgr4	IMP		Mouse	MGI:MGI:5499954|PMID:23589304
Biological Process	GO:0001649	osteoblast differentiation	Lgr4	IMP		Mouse	MGI:MGI:4360132|PMID:19605502
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Lgr4	IMP		Mouse	MGI:MGI:5006869|PMID:21523854
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	LGR4	IDA		Human	PMID:22815884
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Lgr4	IDA		Mouse	MGI:MGI:5499719|PMID:21693646
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Lgr4	IMP		Mouse	MGI:MGI:5494789|PMID:23393138
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Lgr4	IMP		Mouse	MGI:MGI:5141327|PMID:21727895
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lgr4	IMP		Mouse	MGI:MGI:5006869|PMID:21523854
Biological Process	GO:0007283	spermatogenesis	Lgr4	IMP		Mouse	MGI:MGI:5494789|PMID:23393138
Biological Process	GO:0035239	tube morphogenesis	Lgr4	IMP	MGI:MGI:3052121	Mouse	PMID:16406039

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern