Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LGR5
  • Mouse genes Lgr5
  • Rat genes Lgr5
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lgr5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LGR5	IPI	UniProtKB:Q9Z132	Human	PMID:21693646
Molecular Function	GO:0005515	protein binding	LGR5	IPI	UniProtKB:Q2MKA7	Human	PMID:21727895
Molecular Function	GO:0005515	protein binding	LGR5	IPI	UniProtKB:Q2MKA7	Human	PMID:22815884
Molecular Function	GO:0005515	protein binding	LGR5	IPI	UniProtKB:Q6UXX9	Human	PMID:29769720
Molecular Function	GO:0004888	transmembrane signaling receptor activity	LGR5	IDA		Human	PMID:21693646
Molecular Function	GO:0004888	transmembrane signaling receptor activity	LGR5	IDA		Human	PMID:22815884
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Lgr5	IDA		Mouse	MGI:MGI:5141327|PMID:21727895
Cellular Component	GO:0005794	Golgi apparatus	LGR5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	LGR5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	LGR5	IDA		Human	PMID:21693646
Cellular Component	GO:0005886	plasma membrane	LGR5	IDA		Human	PMID:22815884
Cellular Component	GO:0005886	plasma membrane	LGR5	IDA		Human	PMID:23439653
Cellular Component	GO:0032588	trans-Golgi network membrane	LGR5	IDA		Human	PMID:23439653
Biological Process	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis	Lgr5	IGI	MGI:MGI:1891468	Mouse	PMID:24680895
Biological Process	GO:0001942	hair follicle development	Lgr5	IGI	MGI:MGI:1891468	Mouse	PMID:24680895
Biological Process	GO:0048839	inner ear development	Lgr5	IDA		Mouse	PMID:21795542
Biological Process	GO:0009994	oocyte differentiation	Lgr5	IMP		Mouse	PMID:25158167
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	LGR5	IDA		Human	PMID:21693646
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	LGR5	IDA		Human	PMID:22815884
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Lgr5	IMP		Mouse	MGI:MGI:5141327|PMID:21727895
Biological Process	GO:0042127	regulation of cell population proliferation	Lgr5	IGI	MGI:MGI:97363	Mouse	PMID:25535395

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern