Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LHX3
  • Mouse genes Lhx3
  • Rat genes Lhx3
  • Zfish genes lhx3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lhx3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	LHX3	IDA		Human	PMID:15271874
Molecular Function	GO:0005515	protein binding	Lhx3	IPI	UniProtKB:Q9WTV7	Mouse	MGI:MGI:4456957|PMID:11882901
Molecular Function	GO:0005515	protein binding	Lhx3	IPI	UniProtKB:P61372|UniProtKB:P70662	Mouse	MGI:MGI:5508589|PMID:18583962
Molecular Function	GO:0005515	protein binding	Lhx3	IPI	PR:Q9WTV7	Mouse	PMID:10431247
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	LHX3	IPI	UniProtKB:P28069	Human	PMID:26612202
Molecular Function	GO:0043565	sequence-specific DNA binding	LHX3	IDA		Human	PMID:15271874
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Lhx3	IDA		Mouse	MGI:MGI:7339313|PMID:18539116
Molecular Function	GO:0001223	transcription coactivator binding	Lhx3	IPI	UniProtKB:P70662	Mouse	MGI:MGI:7339313|PMID:18539116
Molecular Function	GO:0001221	transcription coregulator binding	Lhx3	IPI	UniProtKB:P61969	Mouse	MGI:MGI:7339313|PMID:18539116
Cellular Component	GO:0000785	chromatin	Lhx3	IDA		Mouse	MGI:MGI:7339313|PMID:18539116
Cellular Component	GO:0005622	intracellular anatomical structure	Lhx3	IDA		Mouse	PMID:10482234
Cellular Component	GO:0005667	transcription regulator complex	Lhx3	IDA		Mouse	MGI:MGI:7339313|PMID:18539116
Cellular Component	GO:0005667	transcription regulator complex	Lhx3	IDA		Mouse	PMID:9192866
Biological Process	GO:0006915	apoptotic process	Lhx3	IMP	MGI:MGI:2385819	Mouse	PMID:18037398
Biological Process	GO:0009953	dorsal/ventral pattern formation	Lhx3	IMP	MGI:MGI:2385819	Mouse	PMID:18037398
Biological Process	GO:0048839	inner ear development	LHX3	IEP		Human	PMID:18407919
Biological Process	GO:0030324	lung development	Lhx3	IEP		Rat	PMID:16798779|RGD:1600300
Biological Process	GO:0021526	medial motor column neuron differentiation	Lhx3	IGI	MGI:MGI:101776	Mouse	PMID:9865699
Biological Process	GO:0008045	motor neuron axon guidance	Lhx3	IGI	MGI:MGI:101776	Mouse	PMID:9865699
Biological Process	GO:0043066	negative regulation of apoptotic process	Lhx3	IMP	MGI:MGI:2385819	Mouse	PMID:18037398
Biological Process	GO:0021983	pituitary gland development	Lhx3	IMP	MGI:MGI:2385819	Mouse	PMID:18037398
Biological Process	GO:0001890	placenta development	Lhx3	IGI	MGI:MGI:101776	Mouse	PMID:18425848
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lhx3	IDA		Mouse	MGI:MGI:5009206|PMID:10593900
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LHX3	IDA		Human	PMID:15271874
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IGI	UniProtKB:P61372	Mouse	MGI:MGI:7339313|PMID:18539116
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IMP		Mouse	MGI:MGI:7339313|PMID:18539116
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IGI	MGI:MGI:107374	Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IGI	MGI:MGI:1342291	Mouse	PMID:10431247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IDA		Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IGI	MGI:MGI:107374	Mouse	PMID:10431247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IGI	MGI:MGI:894670	Mouse	PMID:10431247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IGI	MGI:MGI:894762	Mouse	PMID:9192866
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IGI	MGI:MGI:97588	Mouse	PMID:10431247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx3	IGI	MGI:MGI:894670	Mouse	PMID:9192866
Biological Process	GO:0060127	prolactin secreting cell differentiation	Lhx3	IMP	MGI:MGI:2385819	Mouse	PMID:8638120
Biological Process	GO:0060126	somatotropin secreting cell differentiation	Lhx3	IMP	MGI:MGI:2385819	Mouse	PMID:8638120
Biological Process	GO:0021527	spinal cord association neuron differentiation	Lhx3	IDA		Mouse	PMID:19323994
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	Lhx3	IGI	MGI:MGI:109156	Mouse	PMID:19666821
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	Lhx3	IGI	MGI:MGI:101791	Mouse	PMID:19666821
Biological Process	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	Lhx3	IMP	MGI:MGI:2385819	Mouse	PMID:8638120
Biological Process	GO:0021521	ventral spinal cord interneuron specification	Lhx3	IDA		Mouse	PMID:19666821
Biological Process	GO:0021521	ventral spinal cord interneuron specification	lhx3	IGI	ZFIN:ZDB-MRPHLNO-130401-3,ZFIN:ZDB-MRPHLNO-130401-4	Zfish	PMID:25231761

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern