Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LHX4
  • Mouse genes Lhx4
  • Rat genes Lhx4
  • Zfish genes lhx4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lhx4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	LHX4	IDA		Human	PMID:15998782
Molecular Function	GO:0008327	methyl-CpG binding	LHX4	IDA		Human	PMID:28473536
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P61371	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:O60880	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:O75604	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q17RB8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q6P4F2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q86UY0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9BV90	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9Y5N6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9Y6H1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:O60880	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:O15169	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q96A47	Human	PMID:27820671
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P61371	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q86U70-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q96A47	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:O75604	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P61371	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9Y5N6	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9Y6H1	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:O75865-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P09012	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P25490	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P28069	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P36404	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P36508	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P57086	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P59910	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q00444	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q00526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q2TAL8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q2WGJ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q5QP82	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q5T7W7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q7Z4G4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q7Z6J9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q86U70-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q8IYS8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q8N2Z9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q8N680	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q8N9N5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q96HE7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q96LJ7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9BR76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9BV90	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9C086	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9HD23-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9NP98	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9NR21-1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9UPY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9Y3C0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q9Y5N6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:P25490	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	LHX4	IPI	UniProtKB:Q96A47	Human	PMID:35140242
Molecular Function	GO:0043565	sequence-specific DNA binding	LHX4	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	LHX4	IDA		Human	PMID:28473536
Cellular Component	GO:0005622	intracellular anatomical structure	Lhx4	IDA		Mouse	PMID:10482234
Biological Process	GO:0009887	animal organ morphogenesis	Lhx4	IMP	MGI:MGI:2385815	Mouse	PMID:12183375
Biological Process	GO:0006915	apoptotic process	Lhx4	IMP	MGI:MGI:2385815	Mouse	PMID:12183375
Biological Process	GO:0021526	medial motor column neuron differentiation	Lhx4	IGI	MGI:MGI:102673	Mouse	PMID:9865699
Biological Process	GO:0008045	motor neuron axon guidance	Lhx4	IGI	MGI:MGI:102673	Mouse	PMID:9865699
Biological Process	GO:0043066	negative regulation of apoptotic process	Lhx4	IMP	MGI:MGI:2385815	Mouse	PMID:12183375
Biological Process	GO:0001890	placenta development	Lhx4	IGI	MGI:MGI:102673	Mouse	PMID:18425848
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LHX4	IDA		Human	PMID:15998782
Biological Process	GO:0021521	ventral spinal cord interneuron specification	lhx4	IGI	ZFIN:ZDB-MRPHLNO-130401-3,ZFIN:ZDB-MRPHLNO-130401-4	Zfish	PMID:25231761

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern