Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIF
  • Mouse genes Lif
  • Rat genes Lif
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lif

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	LIF	IDA		Human	PMID:22783022
Molecular Function	GO:0005125	cytokine activity	LIF	IDA		Human	PMID:7957045
Molecular Function	GO:0005125	cytokine activity	Lif	IDA		Mouse	PMID:1522892
Molecular Function	GO:0005125	cytokine activity	Lif	IDA		Mouse	PMID:15012602
Molecular Function	GO:0008083	growth factor activity	LIF	IDA		Human	PMID:12643274
Molecular Function	GO:0008083	growth factor activity	LIF	IDA		Human	PMID:7957045
Molecular Function	GO:0008083	growth factor activity	LIF	IDA		Human	PMID:8999038
Molecular Function	GO:0008083	growth factor activity	Lif	IMP	MGI:MGI:2177780	Mouse	PMID:1522892
Molecular Function	GO:0005146	leukemia inhibitory factor receptor binding	LIF	IDA		Human	PMID:7957045
Molecular Function	GO:0005146	leukemia inhibitory factor receptor binding	LIF	IPI	UniProtKB:P40189	Human	PMID:8999038
Molecular Function	GO:0005146	leukemia inhibitory factor receptor binding	Lif	IMP		Rat	PMID:14638908|RGD:1600617
Molecular Function	GO:0005515	protein binding	LIF	IPI	UniProtKB:P40189	Human	PMID:14527405
Molecular Function	GO:0005515	protein binding	LIF	IPI	UniProtKB:P40189	Human	PMID:16051226
Molecular Function	GO:0005515	protein binding	LIF	IPI	UniProtKB:O60760	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LIF	IPI	UniProtKB:P60328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LIF	IPI	UniProtKB:P61601	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LIF	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005102	signaling receptor binding	LIF	IPI	UniProtKB:P42702	Human	PMID:8999038
Cellular Component	GO:0005829	cytosol	LIF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	Lif	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Lif	IDA		Rat	PMID:20160138|RGD:2326054
Biological Process	GO:0031100	animal organ regeneration	Lif	IMP		Rat	PMID:14638908|RGD:1600617
Biological Process	GO:0031100	animal organ regeneration	Lif	IEP		Rat	PMID:16369772|RGD:2326158
Biological Process	GO:0048708	astrocyte differentiation	Lif	IMP		Rat	PMID:17328769|RGD:2326156
Biological Process	GO:0001974	blood vessel remodeling	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0008283	cell population proliferation	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0046697	decidualization	Lif	IDA		Mouse	PMID:1522892
Biological Process	GO:0046697	decidualization	Lif	IMP	MGI:MGI:2177780	Mouse	PMID:1522892
Biological Process	GO:0007566	embryo implantation	Lif	IMP	MGI:MGI:2177780	Mouse	PMID:1522892
Biological Process	GO:0007566	embryo implantation	Lif	IDA		Mouse	PMID:1522892
Biological Process	GO:0048144	fibroblast proliferation	Lif	IMP	MGI:MGI:2177780	Mouse	PMID:1522892
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	LIF	IDA		Human	PMID:12643274
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	LIF	IDA		Human	PMID:8999038
Biological Process	GO:0048286	lung alveolus development	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0030324	lung development	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0060463	lung lobe morphogenesis	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0060426	lung vasculature development	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0060135	maternal process involved in female pregnancy	Lif	IMP	MGI:MGI:2177780	Mouse	PMID:1522892
Biological Process	GO:0140013	meiotic nuclear division	Lif	IDA		Mouse	PMID:11203703
Biological Process	GO:0048644	muscle organ morphogenesis	Lif	IMP	MGI:MGI:2181618	Mouse	PMID:15716414
Biological Process	GO:0016525	negative regulation of angiogenesis	Lif	IDA		Rat	PMID:16643897|RGD:2326157
Biological Process	GO:0008285	negative regulation of cell population proliferation	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0046888	negative regulation of hormone secretion	LIF	IDA		Human	PMID:7867561
Biological Process	GO:0045835	negative regulation of meiotic nuclear division	Lif	IDA		Mouse	PMID:11203703
Biological Process	GO:0048666	neuron development	Lif	IGI	MGI:MGI:88439	Mouse	PMID:15716414
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	Lif	IDA		Mouse	PMID:10486560
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	LIF	IMP		Human	PMID:26723254
Biological Process	GO:0008284	positive regulation of cell population proliferation	LIF	IDA		Human	PMID:7957045
Biological Process	GO:0008284	positive regulation of cell population proliferation	LIF	IDA		Human	PMID:8999038
Biological Process	GO:0051461	positive regulation of corticotropin secretion	Lif	IDA		Rat	PMID:20160138|RGD:2326054
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Lif	IMP	MGI:MGI:2177780	Mouse	PMID:1522892
Biological Process	GO:0010628	positive regulation of gene expression	Lif	IGI	MGI:MGI:96559	Mouse	PMID:7959007
Biological Process	GO:0010628	positive regulation of gene expression	Lif	IGI	MGI:MGI:96536	Mouse	PMID:7959007
Biological Process	GO:0045651	positive regulation of macrophage differentiation	LIF	IDA		Human	PMID:7957045
Biological Process	GO:0043410	positive regulation of MAPK cascade	LIF	IDA		Human	PMID:7508917
Biological Process	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	LIF	IDA		Human	PMID:20624457
Biological Process	GO:0010976	positive regulation of neuron projection development	Lif	IDA		Rat	PMID:18679704|RGD:2326061
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	LIF	IDA		Human	PMID:7508917
Biological Process	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	LIF	IDA		Human	PMID:20624457
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	LIF	IDA		Human	PMID:7508917
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	LIF	IDA		Human	PMID:22783022
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LIF	IDA		Human	PMID:7508917
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LIF	IDA		Human	PMID:20624457
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LIF	IDA		Human	PMID:22783022
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LIF	IDA		Human	PMID:26723254
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	LIF	IMP		Human	PMID:26723254
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lif	IGI	MGI:MGI:104904	Mouse	PMID:21385842
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lif	IGI	MGI:MGI:103262	Mouse	PMID:21385842
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lif	IGI	MGI:MGI:99147	Mouse	PMID:21385842
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lif	IDA		Mouse	PMID:21385842
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lif	IGI	MGI:MGI:96432	Mouse	PMID:16691571
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	LIF	IDA		Human	PMID:20624457
Biological Process	GO:0045595	regulation of cell differentiation	Lif	IGI	MGI:MGI:1201791	Mouse	PMID:16258063
Biological Process	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	LIF	IDA		Human	PMID:20624457
Biological Process	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	Lif	IDA		Mouse	PMID:21385842
Biological Process	GO:0060041	retina development in camera-type eye	Lif	IDA		Rat	PMID:16643897|RGD:2326157
Biological Process	GO:0035019	somatic stem cell population maintenance	Lif	IGI	MGI:MGI:1201791	Mouse	PMID:15358627
Biological Process	GO:0035019	somatic stem cell population maintenance	Lif	IDA		Mouse	PMID:15358627
Biological Process	GO:0035019	somatic stem cell population maintenance	Lif	IGI	MGI:MGI:1342287	Mouse	PMID:15358627
Biological Process	GO:0060708	spongiotrophoblast differentiation	Lif	IGI	MGI:MGI:1201791	Mouse	PMID:16258063
Biological Process	GO:0048863	stem cell differentiation	Lif	IDA		Mouse	PMID:22949634
Biological Process	GO:0060290	transdifferentiation	Lif	IMP		Rat	PMID:20051627|RGD:2326058
Biological Process	GO:0060707	trophoblast giant cell differentiation	Lif	IGI	MGI:MGI:1201791	Mouse	PMID:16258063
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Lif	IDA		Mouse	PMID:15012602

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern