Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIFR
  • Mouse genes Lifr
  • Rat genes Lifr
  • Zfish genes lifra,lifrb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lifr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	LIFR	IDA		Human	PMID:12643274
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	LIFR	IPI	UniProtKB:P26992	Human	PMID:12707266
Molecular Function	GO:0019955	cytokine binding	Lifr	IMP		Rat	PMID:14638908|RGD:1600617
Molecular Function	GO:0019838	growth factor binding	LIFR	IPI	UniProtKB:P15018	Human	PMID:8999038
Molecular Function	GO:0004923	leukemia inhibitory factor receptor activity	LIFR	IDA		Human	PMID:12643274
Molecular Function	GO:0004923	leukemia inhibitory factor receptor activity	LIFR	IDA		Human	PMID:8999038
Molecular Function	GO:0004923	leukemia inhibitory factor receptor activity	LIFR	IDA		Human	PMID:7957045
Molecular Function	GO:0004923	leukemia inhibitory factor receptor activity	Lifr	IMP		Rat	PMID:14638908|RGD:1600617
Molecular Function	GO:0004924	oncostatin-M receptor activity	LIFR	IDA		Human	PMID:8999038
Molecular Function	GO:0005515	protein binding	LIFR	IPI	UniProtKB:P26441	Human	PMID:16051226
Molecular Function	GO:0005515	protein binding	LIFR	IPI	UniProtKB:P26441	Human	PMID:18775332
Molecular Function	GO:0005515	protein binding	LIFR	IPI	UniProtKB:Q99523	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	Lifr	IPI	PR:Q00560	Mouse	PMID:16452727
Molecular Function	GO:0005515	protein binding	Lifr	IPI	PR:P83714	Mouse	PMID:15051883
Cellular Component	GO:0070062	extracellular exosome	LIFR	HDA		Human	PMID:23533145
Cellular Component	GO:0043235	receptor complex	LIFR	IDA		Human	PMID:12643274
Cellular Component	GO:0043235	receptor complex	LIFR	IDA		Human	PMID:8999038
Biological Process	GO:0031100	animal organ regeneration	Lifr	IMP		Rat	PMID:14638908|RGD:1600617
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	LIFR	IDA		Human	PMID:12643274
Biological Process	GO:0019221	cytokine-mediated signaling pathway	LIFR	IDA		Human	PMID:7957045
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	LIFR	IDA		Human	PMID:12643274
Biological Process	GO:0048861	leukemia inhibitory factor signaling pathway	LIFR	IDA		Human	PMID:8999038
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	Lifr	IMP		Rat	PMID:15927854|RGD:1581857
Biological Process	GO:0048812	neuron projection morphogenesis	Lifr	IDA		Rat	PMID:12871977|RGD:1581861
Biological Process	GO:0038165	oncostatin-M-mediated signaling pathway	LIFR	IMP		Human	PMID:8999038
Biological Process	GO:0008284	positive regulation of cell population proliferation	LIFR	IDA		Human	PMID:7957045
Biological Process	GO:0008284	positive regulation of cell population proliferation	LIFR	IDA		Human	PMID:8999038
Biological Process	GO:0008284	positive regulation of cell population proliferation	Lifr	IGI	MGI:MGI:99605	Mouse	PMID:15051883
Biological Process	GO:0034097	response to cytokine	LIFR	IDA		Human	PMID:8999038
Biological Process	GO:0014070	response to organic cyclic compound	Lifr	IEP		Rat	PMID:16698589|RGD:1581860

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern