Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIG4
  • Mouse genes Lig4
  • Rat genes Lig4
  • Zfish genes lig4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lig4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Lig4	IDA		Mouse	PMID:15194694
Molecular Function	GO:0005524	ATP binding	Lig4	IDA		Rat	PMID:9600082|RGD:1601271
Molecular Function	GO:0003677	DNA binding	LIG4	IDA		Human	PMID:8798671
Molecular Function	GO:0003677	DNA binding	Lig4	IDA		Rat	PMID:9600082|RGD:1601271
Molecular Function	GO:0003910	DNA ligase (ATP) activity	LIG4	IDA		Human	PMID:22192310
Molecular Function	GO:0003910	DNA ligase (ATP) activity	LIG4	IDA		Human	PMID:8798671
Molecular Function	GO:0003910	DNA ligase (ATP) activity	Lig4	IDA		Mouse	PMID:15194694
Molecular Function	GO:0003910	DNA ligase (ATP) activity	Lig4	IDA		Rat	PMID:9600082|RGD:1601271
Molecular Function	GO:0003909	DNA ligase activity	LIG4	IDA		Human	PMID:12517771
Molecular Function	GO:0003909	DNA ligase activity	LIG4	IDA		Human	PMID:17290226
Molecular Function	GO:0016874	ligase activity	LIG4	IDA		Human	PMID:9242410
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:11702069
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:O95347	Human	PMID:12589063
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q9H9Q4	Human	PMID:16439205
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:17290226
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:17389648
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q8IW19	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426-2	Human	PMID:21070942
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:22529269
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q96SD1	Human	PMID:22529269
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426-2	Human	PMID:22658747
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q8IW19	Human	PMID:23178593
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:23219551
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q96SD1	Human	PMID:23219551
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:P49917	Human	PMID:25934149
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:25934149
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q8IW19	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q9H9Q4	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:9242410
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:9259561
Molecular Function	GO:0005515	protein binding	LIG4	IPI	UniProtKB:Q13426	Human	PMID:9809069
Molecular Function	GO:0005515	protein binding	Lig4	IPI	UniProtKB:Q53H47	Mouse	MGI:MGI:5442502|PMID:20620605
Cellular Component	GO:0000793	condensed chromosome	LIG4	IDA		Human	PMID:12589063
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	LIG4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032807	DNA ligase IV complex	LIG4	IMP		Human	PMID:9809069
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	LIG4	IDA		Human	PMID:15194694
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	Lig4	IDA		Mouse	PMID:15194694
Cellular Component	GO:0070419	nonhomologous end joining complex	LIG4	IDA		Human	PMID:20383123
Cellular Component	GO:0070419	nonhomologous end joining complex	LIG4	IDA		Human	PMID:25941166
Cellular Component	GO:0005654	nucleoplasm	LIG4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	LIG4	IDA		Human	PMID:25934149
Cellular Component	GO:0005634	nucleus	LIG4	IDA		Human	PMID:12589063
Cellular Component	GO:0005634	nucleus	LIG4	IDA		Human	PMID:8798671
Cellular Component	GO:0005634	nucleus	Lig4	IDA		Rat	PMID:9600082|RGD:1601271
Biological Process	GO:0071479	cellular response to ionizing radiation	LIG4	IGI	UniProtKB:G5EGA3	Human	PMID:29463814
Biological Process	GO:0071285	cellular response to lithium ion	Lig4	IEP		Rat	PMID:19285016|RGD:2317095
Biological Process	GO:0007417	central nervous system development	Lig4	IMP	MGI:MGI:1857720	Mouse	PMID:9889105
Biological Process	GO:0007417	central nervous system development	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9875844
Biological Process	GO:0007417	central nervous system development	Lig4	IGI	MGI:MGI:98834	Mouse	PMID:10911993
Biological Process	GO:0051276	chromosome organization	Lig4	IGI	MGI:MGI:894697	Mouse	PMID:15175260
Biological Process	GO:1904155	DN2 thymocyte differentiation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10911993
Biological Process	GO:1904155	DN2 thymocyte differentiation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0006266	DNA ligation	LIG4	IDA		Human	PMID:12517771
Biological Process	GO:0006266	DNA ligation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:15968270
Biological Process	GO:0006266	DNA ligation	Lig4	IDA		Mouse	PMID:15194694
Biological Process	GO:0006266	DNA ligation	Lig4	IDA		Rat	PMID:9600082|RGD:1601271
Biological Process	GO:0051102	DNA ligation involved in DNA recombination	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0051103	DNA ligation involved in DNA repair	LIG4	IDA		Human	PMID:12517771
Biological Process	GO:0051103	DNA ligation involved in DNA repair	LIG4	IDA		Human	PMID:17290226
Biological Process	GO:0051103	DNA ligation involved in DNA repair	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0006281	DNA repair	Lig4	IMP		Mouse	PMID:21390131
Biological Process	GO:0006281	DNA repair	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:11779495
Biological Process	GO:0006302	double-strand break repair	LIG4	IDA		Human	PMID:19589734
Biological Process	GO:0006302	double-strand break repair	LIG4	IDA		Human	PMID:9242410
Biological Process	GO:0006302	double-strand break repair	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:12531011
Biological Process	GO:0006302	double-strand break repair	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:15175260
Biological Process	GO:0006302	double-strand break repair	Lig4	IGI	MGI:MGI:104517	Mouse	PMID:12531011
Biological Process	GO:0006302	double-strand break repair	Lig4	IMP	MGI:MGI:3714783	Mouse	PMID:17554302
Biological Process	GO:0006302	double-strand break repair	Lig4	IGI	MGI:MGI:894697	Mouse	PMID:15175260
Biological Process	GO:0097680	double-strand break repair via classical nonhomologous end joining	LIG4	IMP		Human	PMID:24837021
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	LIG4	IDA		Human	PMID:12517771
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	LIG4	IDA		Human	PMID:17290226
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	LIG4	IGI	UniProtKB:Q15554	Human	PMID:23275564
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	LIG4	IMP		Human	PMID:9809069
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Lig4	IMP		Mouse	MGI:MGI:5705227|PMID:12361565
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10823907
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Lig4	IMP	MGI:MGI:1857720	Mouse	PMID:16777961
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	lig4	IMP	ZFIN:ZDB-MRPHLNO-131031-3	Zfish	PMID:23021549
Biological Process	GO:0048144	fibroblast proliferation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0048144	fibroblast proliferation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10911993
Biological Process	GO:0048144	fibroblast proliferation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:15175260
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0001701	in utero embryonic development	Lig4	IMP	MGI:MGI:1857720	Mouse	PMID:16777961
Biological Process	GO:0001701	in utero embryonic development	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0001701	in utero embryonic development	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10911993
Biological Process	GO:0045190	isotype switching	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:17713479
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Lig4	IGI	MGI:MGI:107202	Mouse	PMID:16777961
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9875844
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Lig4	IGI	MGI:MGI:98834	Mouse	PMID:10911993
Biological Process	GO:0022008	neurogenesis	Lig4	IMP	MGI:MGI:1857720	Mouse	PMID:16777961
Biological Process	GO:0022008	neurogenesis	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9875844
Biological Process	GO:0022008	neurogenesis	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10716994
Biological Process	GO:0051402	neuron apoptotic process	Lig4	IGI	MGI:MGI:107202	Mouse	PMID:11248063
Biological Process	GO:0051402	neuron apoptotic process	Lig4	IGI	MGI:MGI:98834	Mouse	PMID:10911993
Biological Process	GO:0051402	neuron apoptotic process	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9875844
Biological Process	GO:0006297	nucleotide-excision repair, DNA gap filling	LIG4	IDA		Human	PMID:12517771
Biological Process	GO:0006297	nucleotide-excision repair, DNA gap filling	LIG4	IDA		Human	PMID:17290226
Biological Process	GO:2001252	positive regulation of chromosome organization	LIG4	IMP		Human	PMID:23275564
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10911993
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0050769	positive regulation of neurogenesis	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10716994
Biological Process	GO:0050769	positive regulation of neurogenesis	Lig4	IMP	MGI:MGI:1857720	Mouse	PMID:16777961
Biological Process	GO:0050769	positive regulation of neurogenesis	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9875844
Biological Process	GO:0002328	pro-B cell differentiation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0002328	pro-B cell differentiation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10911993
Biological Process	GO:0010332	response to gamma radiation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10911993
Biological Process	GO:0010332	response to gamma radiation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:9823897
Biological Process	GO:0010212	response to ionizing radiation	Lig4	IMP		Mouse	PMID:21390131
Biological Process	GO:0010212	response to ionizing radiation	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10823907
Biological Process	GO:0010165	response to X-ray	LIG4	IMP		Human	PMID:9809069
Biological Process	GO:0000012	single strand break repair	LIG4	IDA		Human	PMID:8798671
Biological Process	GO:0035019	somatic stem cell population maintenance	Lig4	IMP	MGI:MGI:3714783	Mouse	PMID:17554302
Biological Process	GO:0072089	stem cell proliferation	Lig4	IMP	MGI:MGI:3714783	Mouse	PMID:17554302
Biological Process	GO:0033153	T cell receptor V(D)J recombination	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10911993
Biological Process	GO:0033151	V(D)J recombination	LIG4	IDA		Human	PMID:9809069
Biological Process	GO:0033151	V(D)J recombination	Lig4	IMP	MGI:MGI:1857732	Mouse	PMID:10716994
Biological Process	GO:0033151	V(D)J recombination	Lig4	IDA		Mouse	PMID:15194694

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern