Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LILRB4
  • Mouse genes Lilrb4a
  • Rat genes Lilrb4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lilrb4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034185	apolipoprotein binding	LILRB4	IDA		Human	PMID:30333625
Molecular Function	GO:0001968	fibronectin binding	LILRB4	IDA		Human	PMID:34089617
Molecular Function	GO:0001968	fibronectin binding	Lilrb4a	IDA		Mouse	MGI:MGI:6827321|PMID:34089617
Molecular Function	GO:0005178	integrin binding	Lilrb4a	IDA		Mouse	MGI:MGI:6467920|PMID:11323698
Molecular Function	GO:0019902	phosphatase binding	Lilrb4a	IPI	UniProtKB:P29351	Mouse	MGI:MGI:6827313|PMID:9973385
Molecular Function	GO:0005515	protein binding	LILRB4	IPI	UniProtKB:P29350	Human	PMID:18802077
Molecular Function	GO:0019903	protein phosphatase binding	LILRB4	IPI	UniProtKB:P29350	Human	PMID:16493035
Molecular Function	GO:0019903	protein phosphatase binding	Lilrb4a	IPI	UniProtKB:P29351|UniProtKB:P35235	Mouse	MGI:MGI:6827314|PMID:10026201
Molecular Function	GO:0030547	signaling receptor inhibitor activity	LILRB4	IDA		Human	PMID:9151699
Molecular Function	GO:0030293	transmembrane receptor protein tyrosine kinase inhibitor activity	LILRB4	IMP		Human	PMID:16493035
Molecular Function	GO:0030293	transmembrane receptor protein tyrosine kinase inhibitor activity	LILRB4	IDA		Human	PMID:9151699
Cellular Component	GO:0009986	cell surface	LILRB4	IDA		Human	PMID:19833736
Cellular Component	GO:0009986	cell surface	LILRB4	IDA		Human	PMID:9151699
Cellular Component	GO:0009986	cell surface	Lilrb4a	IDA		Mouse	MGI:MGI:1889426|PMID:10982834
Cellular Component	GO:0009986	cell surface	Lilrb4a	IDA		Mouse	MGI:MGI:6467920|PMID:11323698
Cellular Component	GO:0009986	cell surface	Lilrb4a	IDA		Mouse	MGI:MGI:85128|PMID:8855262
Cellular Component	GO:0009986	cell surface	Lilrb4a	IDA		Mouse	MGI:MGI:6828674|PMID:8977169
Cellular Component	GO:0009897	external side of plasma membrane	Lilrb4a	IDA		Mouse	PMID:14557414
Cellular Component	GO:0009897	external side of plasma membrane	Lilrb4a	IDA		Mouse	PMID:19966208
Cellular Component	GO:0009897	external side of plasma membrane	Lilrb4a	IDA		Mouse	PMID:17761953
Cellular Component	GO:0070062	extracellular exosome	LILRB4	HDA		Human	PMID:23533145
Biological Process	GO:0007596	blood coagulation	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:14557414
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Lilrb4a	IMP	MGI:3818260	Mouse	PMID:18792399
Biological Process	GO:0035740	CD8-positive, alpha-beta T cell proliferation	Lilrb4a	IMP	MGI:3818260	Mouse	PMID:18792399
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:14557414
Biological Process	GO:0032602	chemokine production	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:15827966
Biological Process	GO:0001816	cytokine production	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:15827966
Biological Process	GO:0002774	Fc receptor mediated inhibitory signaling pathway	LILRB4	IDA		Human	PMID:16493035
Biological Process	GO:0002774	Fc receptor mediated inhibitory signaling pathway	LILRB4	IDA		Human	PMID:18420485
Biological Process	GO:0006954	inflammatory response	Lilrb4a	IMP	MGI:MGI:2386122	Mouse	PMID:17761953
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:19966208
Biological Process	GO:0140105	interleukin-10-mediated signaling pathway	LILRB4	IEP		Human	PMID:17163451
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	LILRB4	IMP		Human	PMID:19380766
Biological Process	GO:0032682	negative regulation of chemokine production	LILRB4	IMP		Human	PMID:19380766
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	LILRB4	IMP		Human	PMID:19380766
Biological Process	GO:0045584	negative regulation of cytotoxic T cell differentiation	LILRB4	IMP		Human	PMID:16493035
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	LILRB4	IMP		Human	PMID:19380766
Biological Process	GO:0002638	negative regulation of immunoglobulin production	Lilrb4a	IMP		Mouse	MGI:MGI:6810286|PMID:24935931
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	LILRB4	IMP		Human	PMID:19380766
Biological Process	GO:0032693	negative regulation of interleukin-10 production	LILRB4	IDA		Human	PMID:18420485
Biological Process	GO:0032703	negative regulation of interleukin-2 production	LILRB4	IDA		Human	PMID:18420485
Biological Process	GO:0032714	negative regulation of interleukin-5 production	LILRB4	IDA		Human	PMID:18420485
Biological Process	GO:0032715	negative regulation of interleukin-6 production	LILRB4	IMP		Human	PMID:19380766
Biological Process	GO:0071659	negative regulation of IP-10 production	LILRB4	IMP		Human	PMID:19380766
Biological Process	GO:0043409	negative regulation of MAPK cascade	LILRB4	IMP		Human	PMID:19380766
Biological Process	GO:0033004	negative regulation of mast cell activation	Lilrb4a	IMP		Mouse	MGI:MGI:2670827|PMID:12884301
Biological Process	GO:0033007	negative regulation of mast cell activation involved in immune response	Lilrb4a	IMP		Mouse	MGI:MGI:2137455|PMID:11457897
Biological Process	GO:0033007	negative regulation of mast cell activation involved in immune response	Lilrb4a	IPI	GO:0034683	Mouse	MGI:MGI:6467920|PMID:11323698
Biological Process	GO:0033007	negative regulation of mast cell activation involved in immune response	Lilrb4a	IDA		Mouse	MGI:MGI:6827314|PMID:10026201
Biological Process	GO:0033007	negative regulation of mast cell activation involved in immune response	Lilrb4a	IDA		Mouse	MGI:MGI:85128|PMID:8855262
Biological Process	GO:1902894	negative regulation of miRNA transcription	LILRB4	IDA		Human	PMID:22387553
Biological Process	GO:0150102	negative regulation of monocyte activation	LILRB4	IDA		Human	PMID:19833736
Biological Process	GO:0150102	negative regulation of monocyte activation	LILRB4	IDA		Human	PMID:34089617
Biological Process	GO:0150102	negative regulation of monocyte activation	LILRB4	IMP		Human	PMID:9151699
Biological Process	GO:0150102	negative regulation of monocyte activation	Lilrb4a	IDA		Mouse	MGI:MGI:6827321|PMID:34089617
Biological Process	GO:0032815	negative regulation of natural killer cell activation	Lilrb4a	IDA		Mouse	MGI:MGI:6828674|PMID:8977169
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	LILRB4	IDA		Human	PMID:18802077
Biological Process	GO:1900099	negative regulation of plasma cell differentiation	Lilrb4a	IMP		Mouse	MGI:MGI:6810286|PMID:24935931
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	LILRB4	IDA		Human	PMID:22387553
Biological Process	GO:0061099	negative regulation of protein tyrosine kinase activity	LILRB4	IMP		Human	PMID:16493035
Biological Process	GO:0061099	negative regulation of protein tyrosine kinase activity	LILRB4	IDA		Human	PMID:9151699
Biological Process	GO:2000272	negative regulation of signaling receptor activity	LILRB4	IDA		Human	PMID:9151699
Biological Process	GO:2000524	negative regulation of T cell costimulation	LILRB4	IMP		Human	PMID:17163451
Biological Process	GO:0002725	negative regulation of T cell cytokine production	LILRB4	IDA		Human	PMID:18420485
Biological Process	GO:0042130	negative regulation of T cell proliferation	LILRB4	IMP		Human	PMID:17163451
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	LILRB4	IMP		Human	PMID:16493035
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	LILRB4	IDA		Human	PMID:22387553
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	LILRB4	IDA		Human	PMID:19833736
Biological Process	GO:0032689	negative regulation of type II interferon production	LILRB4	IDA		Human	PMID:20007427
Biological Process	GO:0001780	neutrophil homeostasis	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:15827966
Biological Process	GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	LILRB4	IDA		Human	PMID:18420485
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	LILRB4	IDA		Human	PMID:20935202
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	LILRB4	IDA		Human	PMID:22387553
Biological Process	GO:0002669	positive regulation of T cell anergy	LILRB4	IMP		Human	PMID:16493035
Biological Process	GO:0031623	receptor internalization	LILRB4	IMP		Human	PMID:9151699
Biological Process	GO:0009991	response to extracellular stimulus	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:23431396
Biological Process	GO:0032496	response to lipopolysaccharide	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:23431396
Biological Process	GO:0032496	response to lipopolysaccharide	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:15827966
Biological Process	GO:0032496	response to lipopolysaccharide	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:14557414
Biological Process	GO:0009624	response to nematode	Lilrb4a	IMP	MGI:MGI:2386122	Mouse	PMID:17761953
Biological Process	GO:0051707	response to other organism	Lilrb4a	IMP	MGI:3818260	Mouse	PMID:28883820
Biological Process	GO:0009611	response to wounding	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:14557414
Biological Process	GO:0002507	tolerance induction	LILRB4	IDA		Human	PMID:18420485
Biological Process	GO:0002507	tolerance induction	LILRB4	IDA		Human	PMID:20935202
Biological Process	GO:0042092	type 2 immune response	Lilrb4a	IMP	MGI:2653049	Mouse	PMID:19966208

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern