Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIMA1
  • Mouse genes Lima1
  • Rat genes Lima1
  • Zfish genes lima1a,lima1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lima1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	LIMA1	IDA		Human	PMID:12566430
Molecular Function	GO:0051015	actin filament binding	Lima1	IMP		Mouse	MGI:MGI:3768577|PMID:17875928
Molecular Function	GO:0003785	actin monomer binding	LIMA1	IDA		Human	PMID:12566430
Molecular Function	GO:0045296	cadherin binding	LIMA1	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	LIMA1	IPI	UniProtKB:P12830	Human	PMID:18093941
Molecular Function	GO:0005515	protein binding	LIMA1	IPI	UniProtKB:P35221	Human	PMID:18093941
Molecular Function	GO:0005515	protein binding	LIMA1	IPI	UniProtKB:O46385	Human	PMID:20309963
Molecular Function	GO:0005515	protein binding	LIMA1	IPI	UniProtKB:P49023	Human	PMID:24694988
Molecular Function	GO:0005515	protein binding	LIMA1	IPI	UniProtKB:P53355	Human	PMID:29513927
Molecular Function	GO:0005515	protein binding	LIMA1	IPI	UniProtKB:Q9UHC9	Human	PMID:29880681
Molecular Function	GO:0005515	protein binding	LIMA1	IPI	UniProtKB:P53355	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Lima1	IPI	UniProtKB:P35221-1|UniProtKB:P35221	Mouse	MGI:MGI:6093103|PMID:18093941
Molecular Function	GO:0005515	protein binding	Lima1	IPI	UniProtKB:P21271|UniProtKB:Q6T3U4	Mouse	MGI:MGI:6160379|PMID:29880681
Molecular Function	GO:0005515	protein binding	Lima1	IPI	PR:P39053	Mouse	PMID:23746204
Cellular Component	GO:0015629	actin cytoskeleton	LIMA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0015629	actin cytoskeleton	LIMA1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0015629	actin cytoskeleton	Lima1	IDA		Mouse	PMID:11179679
Cellular Component	GO:0005903	brush border	Lima1	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0031526	brush border membrane	Lima1	IDA		Mouse	MGI:MGI:6160379|PMID:29880681
Cellular Component	GO:0032154	cleavage furrow	LIMA1	IDA		Human	PMID:20309963
Cellular Component	GO:0005829	cytosol	LIMA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	LIMA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	LIMA1	IDA		Human	PMID:10618726
Cellular Component	GO:0005925	focal adhesion	LIMA1	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	LIMA1	IDA		Human	PMID:24694988
Cellular Component	GO:0005886	plasma membrane	LIMA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001726	ruffle	Lima1	IDA		Mouse	MGI:MGI:3768577|PMID:17875928
Cellular Component	GO:0001725	stress fiber	LIMA1	IDA		Human	PMID:10618726
Biological Process	GO:0051017	actin filament bundle assembly	LIMA1	IDA		Human	PMID:12566430
Biological Process	GO:0016477	cell migration	Lima1	IMP		Mouse	MGI:MGI:3768577|PMID:17875928
Biological Process	GO:0042632	cholesterol homeostasis	Lima1	IMP		Mouse	MGI:MGI:6160379|PMID:29880681
Biological Process	GO:0030299	intestinal cholesterol absorption	Lima1	IMP		Mouse	MGI:MGI:6160379|PMID:29880681
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	LIMA1	IDA		Human	PMID:12566430
Biological Process	GO:0031529	ruffle organization	LIMA1	IDA		Human	PMID:12566430
Biological Process	GO:0031529	ruffle organization	Lima1	IMP		Mouse	MGI:MGI:3768577|PMID:17875928

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern