Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIMK1
  • Mouse genes Limk1
  • Rat genes Limk1
  • Zfish genes limk1a,limk1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Limk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031072	heat shock protein binding	LIMK1	IDA		Human	PMID:17512523
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:Q13153	Human	PMID:10559936
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:Q13464	Human	PMID:10652353
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:O95835	Human	PMID:15220930
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:Q8WYL5	Human	PMID:15660133
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:Q13177	Human	PMID:16837009
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:P29066	Human	PMID:17500066
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:P29067	Human	PMID:17500066
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:O60260	Human	PMID:17512523
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:Q9UNE7	Human	PMID:17512523
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:P23528	Human	PMID:17853892
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:O94811	Human	PMID:18028908
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:P23528	Human	PMID:19424295
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:P23528	Human	PMID:20133759
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:P50281	Human	PMID:21219645
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:Q8WYQ4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LIMK1	IPI	UniProtKB:P63319	Human	PMID:8940095
Molecular Function	GO:0005515	protein binding	Limk1	IPI	UniProtKB:Q9QUI1	Mouse	MGI:MGI:5908532|PMID:25107909
Molecular Function	GO:0005515	protein binding	Limk1	IPI	PR:O54785	Mouse	PMID:16399995
Molecular Function	GO:0005515	protein binding	Limk1	IPI	PR:Q9WTV7	Mouse	PMID:10431247
Molecular Function	GO:0005515	protein binding	Limk1	IPI	PR:Q9DBU5	Mouse	PMID:16204183
Molecular Function	GO:0005515	protein binding	Limk1	IPI	PR:Q8VI36	Mouse	PMID:16399995
Molecular Function	GO:0005515	protein binding	Limk1	IPI	UniProtKB:O88294	Mouse	PMID:15023529
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LIMK1	IDA		Human	PMID:22328514
Cellular Component	GO:0044295	axonal growth cone	Limk1	IDA		Rat	PMID:15090620|RGD:5131992
Cellular Component	GO:0005737	cytoplasm	LIMK1	IDA		Human	PMID:17512523
Cellular Component	GO:0005737	cytoplasm	Limk1	IDA		Mouse	MGI:MGI:3603857|PMID:16204183
Cellular Component	GO:0005737	cytoplasm	Limk1	IDA		Mouse	PMID:16399995
Cellular Component	GO:0005829	cytosol	LIMK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	Limk1	IDA		Mouse	PMID:15023529
Cellular Component	GO:0005925	focal adhesion	Limk1	IDA		Mouse	PMID:16399995
Cellular Component	GO:0005794	Golgi apparatus	Limk1	IDA		Rat	PMID:15090620|RGD:5131992
Cellular Component	GO:0030027	lamellipodium	Limk1	IDA		Mouse	MGI:MGI:5908532|PMID:25107909
Cellular Component	GO:0001673	male germ cell nucleus	Limk1	IDA		Mouse	PMID:16399995
Cellular Component	GO:0016020	membrane	Limk1	IDA		Mouse	PMID:24792215
Cellular Component	GO:0043005	neuron projection	Limk1	IDA		Mouse	MGI:MGI:3603857|PMID:16204183
Cellular Component	GO:0016607	nuclear speck	LIMK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Limk1	IDA		Mouse	PMID:15023529
Cellular Component	GO:0005634	nucleus	Limk1	IDA		Mouse	PMID:16399995
Cellular Component	GO:0005634	nucleus	Limk1	IDA		Rat	PMID:15090620|RGD:5131992
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Limk1	IDA		Rat	PMID:15090620|RGD:5131992
Biological Process	GO:0048675	axon extension	Limk1	IGI	MGI:MGI:1921382	Mouse	PMID:16204183
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	LIMK1	IDA		Human	PMID:17512523
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	LIMK1	IDA		Human	PMID:17512523
Biological Process	GO:0045773	positive regulation of axon extension	Limk1	IGI	MGI:MGI:1921382	Mouse	PMID:16204183
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Limk1	IGI	MGI:MGI:88190	Mouse	PMID:15199148
Biological Process	GO:0006468	protein phosphorylation	LIMK1	IDA		Human	PMID:17512523
Biological Process	GO:0006468	protein phosphorylation	LIMK1	IDA		Human	PMID:22328514
Biological Process	GO:0006468	protein phosphorylation	LIMK1	IMP		Human	PMID:23633677
Biological Process	GO:0001878	response to yeast	limk1a	IDA		Zfish	PMID:23947337
Biological Process	GO:0043149	stress fiber assembly	Limk1	IGI	MGI:MGI:88190	Mouse	PMID:15199148

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern