Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIMS1
  • Mouse genes Lims1
  • Rat genes Lims1
  • Zfish genes lims1,lims2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lims1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:O43639	Human	PMID:10574708
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:O55222	Human	PMID:10574708
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:O55222	Human	PMID:11331308
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:11331308
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:O55222	Human	PMID:12432066
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:O43639	Human	PMID:15721255
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:18339839
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:19074270
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q15404	Human	PMID:20926685
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:P19544	Human	PMID:21390327
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:P09022	Human	PMID:23088713
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q15404	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:23877428
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q15404	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q15404	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q15404	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Lims1	IPI	PR:O55222	Mouse	PMID:12432066
Molecular Function	GO:0005515	protein binding	Lims1	IPI	PR:P20065	Mouse	PMID:15565145
Molecular Function	GO:0005515	protein binding	Lims1	IPI	PR:Q9EPC1	Mouse	PMID:12432066
Molecular Function	GO:0019901	protein kinase binding	LIMS1	IPI	UniProtKB:Q13418	Human	PMID:20926685
Molecular Function	GO:0044877	protein-containing complex binding	Lims1	IDA		Rat	PMID:17167118|RGD:2302524
Molecular Function	GO:0044877	protein-containing complex binding	Lims1	IPI	RGD:620063|RGD:71021	Rat	PMID:17934340|RGD:2301743
Molecular Function	GO:0008270	zinc ion binding	LIMS1	IDA		Human	PMID:19074270
Cellular Component	GO:0005911	cell-cell junction	LIMS1	IMP		Human	PMID:20926685
Cellular Component	GO:0005925	focal adhesion	LIMS1	IDA		Human	PMID:19117955
Cellular Component	GO:0005925	focal adhesion	LIMS1	IDA		Human	PMID:20926685
Cellular Component	GO:0005925	focal adhesion	LIMS1	IDA		Human	PMID:21390327
Cellular Component	GO:0005925	focal adhesion	LIMS1	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	Lims1	IDA		Mouse	PMID:12651156
Cellular Component	GO:0005925	focal adhesion	Lims1	IDA		Mouse	PMID:12432066
Cellular Component	GO:0014704	intercalated disc	lims1	IDA		Zfish	PMID:21670146
Cellular Component	GO:0048471	perinuclear region of cytoplasm	LIMS1	IDA		Human	PMID:21390327
Cellular Component	GO:0032991	protein-containing complex	Lims1	IDA		Rat	PMID:17167118|RGD:2302524
Cellular Component	GO:0032991	protein-containing complex	Lims1	IDA		Rat	PMID:17934340|RGD:2301743
Cellular Component	GO:0030018	Z disc	lims1	IDA		Zfish	PMID:21670146
Biological Process	GO:0098609	cell-cell adhesion	Lims1	IMP	MGI:MGI:3584172	Mouse	PMID:15976450
Biological Process	GO:0098609	cell-cell adhesion	Lims1	IMP	MGI:MGI:3584173	Mouse	PMID:15976450
Biological Process	GO:0045216	cell-cell junction organization	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:19652092
Biological Process	GO:0007160	cell-matrix adhesion	Lims1	IMP	MGI:MGI:3584173	Mouse	PMID:15976450
Biological Process	GO:0007160	cell-matrix adhesion	Lims1	IMP	MGI:MGI:3584172	Mouse	PMID:15976450
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	LIMS1	IEP		Human	PMID:21390327
Biological Process	GO:1990705	cholangiocyte proliferation	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:24058607
Biological Process	GO:0043009	chordate embryonic development	Lims1	IMP	MGI:MGI:3577473	Mouse	PMID:15798193
Biological Process	GO:0045184	establishment of protein localization	LIMS1	IMP		Human	PMID:20926685
Biological Process	GO:0007163	establishment or maintenance of cell polarity	Lims1	IMP	MGI:MGI:3584173	Mouse	PMID:15976450
Biological Process	GO:0007163	establishment or maintenance of cell polarity	Lims1	IMP	MGI:MGI:3584172	Mouse	PMID:15976450
Biological Process	GO:0060047	heart contraction	lims1	IMP	ZFIN:ZDB-MRPHLNO-110907-4	Zfish	PMID:21670146
Biological Process	GO:0060047	heart contraction	lims2	IMP	ZFIN:ZDB-MRPHLNO-110907-6	Zfish	PMID:21670146
Biological Process	GO:0097284	hepatocyte apoptotic process	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:24058607
Biological Process	GO:0007229	integrin-mediated signaling pathway	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:19652092
Biological Process	GO:1904055	negative regulation of cholangiocyte proliferation	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:24058607
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	LIMS1	IDA		Human	PMID:21390327
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:24058607
Biological Process	GO:2000346	negative regulation of hepatocyte proliferation	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:24058607
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:24719101
Biological Process	GO:0061351	neural precursor cell proliferation	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:24719101
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	LIMS1	IMP		Human	PMID:20926685
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	LIMS1	IMP		Human	PMID:20926685
Biological Process	GO:0010628	positive regulation of gene expression	LIMS1	IMP		Human	PMID:20926685
Biological Process	GO:0043547	positive regulation of GTPase activity	LIMS1	IMP		Human	PMID:20926685
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	Lims1	IGI	MGI:MGI:2385067	Mouse	PMID:19652092
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	LIMS1	IMP		Human	PMID:21343177
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	LIMS1	IMP		Human	PMID:20926685
Biological Process	GO:0051896	regulation of protein kinase B signaling	lims1	IMP	ZFIN:ZDB-MRPHLNO-110907-4	Zfish	PMID:21670146
Biological Process	GO:0051896	regulation of protein kinase B signaling	lims2	IMP	ZFIN:ZDB-MRPHLNO-110907-4	Zfish	PMID:21670146
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	LIMS1	IMP		Human	PMID:21343177

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern