Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIMS2
  • Mouse genes Lims2
  • Rat genes Lims2
  • Zfish genes lims2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lims2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Cellular Component	GO:0005925	focal adhesion	LIMS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	LIMS2	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	Lims2	IDA		Mouse	PMID:12651156
Biological Process	GO:0098609	cell-cell adhesion	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:19652092
Biological Process	GO:0045216	cell-cell junction organization	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:19652092
Biological Process	GO:1990705	cholangiocyte proliferation	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:24058607
Biological Process	GO:0060047	heart contraction	lims2	IMP	ZFIN:ZDB-MRPHLNO-110907-6	Zfish	PMID:21670146
Biological Process	GO:0007229	integrin-mediated signaling pathway	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:19652092
Biological Process	GO:0043066	negative regulation of apoptotic process	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:24058607
Biological Process	GO:1904055	negative regulation of cholangiocyte proliferation	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:24058607
Biological Process	GO:2000346	negative regulation of hepatocyte proliferation	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:24058607
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:24719101
Biological Process	GO:0061351	neural precursor cell proliferation	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:24719101
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	Lims2	IGI	MGI:MGI:1195263	Mouse	PMID:19652092
Biological Process	GO:0051896	regulation of protein kinase B signaling	lims2	IMP	ZFIN:ZDB-MRPHLNO-110907-4	Zfish	PMID:21670146

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern