Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIN28A
  • Mouse genes Lin28a
  • Rat genes Lin28a
  • Zfish genes lin28aa,lin28ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lin28a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002151	G-quadruplex RNA binding	Lin28a	IDA		Mouse	MGI:MGI:5795796|PMID:26045559
Molecular Function	GO:0035198	miRNA binding	Lin28a	IDA		Mouse	MGI:MGI:5795796|PMID:26045559
Molecular Function	GO:0035198	miRNA binding	Lin28a	IDA		Mouse	MGI:MGI:6162440|PMID:28671666
Molecular Function	GO:0035198	miRNA binding	Lin28a	IDA		Mouse	PMID:18604195
Molecular Function	GO:0003729	mRNA binding	Lin28a	IDA		Mouse	PMID:17473174
Molecular Function	GO:1905538	polysome binding	LIN28A	IDA		Human	PMID:21247876
Molecular Function	GO:0070883	pre-miRNA binding	LIN28A	IDA		Human	PMID:21247876
Molecular Function	GO:0005515	protein binding	LIN28A	IPI	UniProtKB:Q5TAX3	Human	PMID:19703396
Molecular Function	GO:0005515	protein binding	LIN28A	IPI	UniProtKB:Q08211	Human	PMID:21247876
Molecular Function	GO:0005515	protein binding	LIN28A	IPI	UniProtKB:Q9NSD4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LIN28A	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Lin28a	IPI	UniProtKB:Q8CI75	Mouse	MGI:MGI:5494337|PMID:23594738
Molecular Function	GO:0005515	protein binding	Lin28a	IPI	UniProtKB:B2RX14	Mouse	MGI:MGI:6162440|PMID:28671666
Molecular Function	GO:0140517	protein-RNA adaptor activity	LIN28A	IDA		Human	PMID:18951094
Molecular Function	GO:0003723	RNA binding	LIN28A	IDA		Human	PMID:19703396
Molecular Function	GO:0003723	RNA binding	Lin28a	IDA		Mouse	MGI:MGI:5795814|PMID:23102813
Molecular Function	GO:0003723	RNA binding	Lin28a	IDA		Mouse	MGI:MGI:4359358|PMID:18604195
Molecular Function	GO:0003723	RNA binding	Lin28a	IDA		Mouse	MGI:MGI:4359360|PMID:18292307
Molecular Function	GO:1990825	sequence-specific mRNA binding	Lin28a	IDA		Mouse	MGI:MGI:5795796|PMID:26045559
Molecular Function	GO:0031369	translation initiation factor binding	Lin28a	IPI	PR:Q8JZQ9	Mouse	PMID:17473174
Cellular Component	GO:0005737	cytoplasm	LIN28A	IDA		Human	PMID:18604195
Cellular Component	GO:0005737	cytoplasm	LIN28A	IDA		Human	PMID:20014101
Cellular Component	GO:0005737	cytoplasm	Lin28a	IDA		Mouse	PMID:17473174
Cellular Component	GO:0005737	cytoplasm	Lin28a	IDA		Mouse	PMID:12798299
Cellular Component	GO:0005737	cytoplasm	Lin28a	IDA		Mouse	PMID:18604195
Cellular Component	GO:0010494	cytoplasmic stress granule	LIN28A	IDA		Human	PMID:17617744
Cellular Component	GO:0005829	cytosol	LIN28A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	LIN28A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	Lin28a	IDA		Mouse	PMID:17473174
Cellular Component	GO:0005634	nucleus	LIN28A	IDA		Human	PMID:17617744
Cellular Component	GO:0000932	P-body	LIN28A	IDA		Human	PMID:17617744
Cellular Component	GO:0005844	polysome	LIN28A	IDA		Human	PMID:21247876
Cellular Component	GO:1990904	ribonucleoprotein complex	LIN28A	IDA		Human	PMID:21247876
Cellular Component	GO:0005791	rough endoplasmic reticulum	Lin28a	IDA		Mouse	MGI:MGI:5795814|PMID:23102813
Biological Process	GO:0071333	cellular response to glucose stimulus	Lin28a	IMP		Mouse	MGI:MGI:5294254|PMID:21962509
Biological Process	GO:0043009	chordate embryonic development	lin28ab	IMP	ZFIN:ZDB-MRPHLNO-140708-3	Zfish	PMID:24516585
Biological Process	GO:0007281	germ cell development	Lin28a	IMP		Mouse	PMID:19578360
Biological Process	GO:0007281	germ cell development	Lin28a	IGI	MGI:MGI:99655	Mouse	PMID:19578360
Biological Process	GO:0010587	miRNA catabolic process	LIN28A	IMP		Human	PMID:18951094
Biological Process	GO:0010587	miRNA catabolic process	LIN28A	IMP		Human	PMID:19703396
Biological Process	GO:0010587	miRNA catabolic process	Lin28a	IMP		Mouse	MGI:MGI:4359358|PMID:18604195
Biological Process	GO:0010587	miRNA catabolic process	Lin28a	IMP		Mouse	MGI:MGI:4359360|PMID:18292307
Biological Process	GO:0010587	miRNA catabolic process	Lin28a	IDA		Mouse	MGI:MGI:5294254|PMID:21962509
Biological Process	GO:0010586	miRNA metabolic process	Lin28a	IDA		Mouse	PMID:20179095
Biological Process	GO:0010629	negative regulation of gene expression	lin28ab	IMP	ZFIN:ZDB-MRPHLNO-110913-2	Zfish	PMID:21911394
Biological Process	GO:0010629	negative regulation of gene expression	lin28ab	IMP	ZFIN:ZDB-MRPHLNO-110913-1	Zfish	PMID:21911394
Biological Process	GO:0045686	negative regulation of glial cell differentiation	Lin28a	IDA		Mouse	PMID:20179095
Biological Process	GO:2000632	negative regulation of pre-miRNA processing	LIN28A	IDA		Human	PMID:21247876
Biological Process	GO:0017148	negative regulation of translation	Lin28a	IDA		Mouse	MGI:MGI:5795814|PMID:23102813
Biological Process	GO:1901724	positive regulation of cell proliferation involved in kidney development	Lin28a	IMP		Mouse	MGI:MGI:5574232|PMID:24732380
Biological Process	GO:2000767	positive regulation of cytoplasmic translation	LIN28A	IMP		Human	PMID:21247876
Biological Process	GO:0045666	positive regulation of neuron differentiation	Lin28a	IDA		Mouse	PMID:20179095
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Lin28a	IDA		Mouse	MGI:MGI:5294254|PMID:21962509
Biological Process	GO:0032008	positive regulation of TOR signaling	Lin28a	IDA		Mouse	MGI:MGI:5294254|PMID:21962509
Biological Process	GO:0045727	positive regulation of translation	Lin28a	IDA		Mouse	PMID:17473174
Biological Process	GO:0031054	pre-miRNA processing	LIN28A	IMP		Human	PMID:19703396
Biological Process	GO:0031054	pre-miRNA processing	Lin28a	IMP		Mouse	MGI:MGI:4359358|PMID:18604195
Biological Process	GO:0031054	pre-miRNA processing	Lin28a	IMP		Mouse	MGI:MGI:4359360|PMID:18292307
Biological Process	GO:0031054	pre-miRNA processing	Lin28a	IDA		Mouse	PMID:18604195
Biological Process	GO:0031099	regeneration	lin28ab	IMP	ZFIN:ZDB-MRPHLNO-110913-2	Zfish	PMID:20935637
Biological Process	GO:0031099	regeneration	lin28ab	IMP	ZFIN:ZDB-MRPHLNO-110913-1	Zfish	PMID:20935637
Biological Process	GO:0060964	regulation of miRNA-mediated gene silencing	Lin28a	IGI	MGI:MGI:2685973	Mouse	PMID:19898466
Biological Process	GO:0071076	RNA 3' uridylation	Lin28a	IDA		Mouse	MGI:MGI:6377821|PMID:18951094
Biological Process	GO:0031123	RNA 3'-end processing	LIN28A	IMP		Human	PMID:19703396
Biological Process	GO:0048863	stem cell differentiation	Lin28a	IMP		Mouse	MGI:MGI:4359360|PMID:18292307
Biological Process	GO:0048863	stem cell differentiation	Lin28a	IMP		Mouse	MGI:MGI:4359358|PMID:18604195
Biological Process	GO:0019827	stem cell population maintenance	LIN28A	IMP		Human	PMID:19703396

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern