Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LMNA
  • Mouse genes Lmna
  • Rat genes Lmna
  • Zfish genes lmna
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lmna

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9UHQ1	Human	PMID:10514485
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P18054	Human	PMID:10727209
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P50402	Human	PMID:11587540
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8NF91	Human	PMID:11801724
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P50402	Human	PMID:14597414
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P10215	Human	PMID:15140953
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P10218	Human	PMID:15140953
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8WXH0	Human	PMID:15671068
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P42166	Human	PMID:16247757
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P50402	Human	PMID:19323649
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9D666	Human	PMID:19933576
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9UH99	Human	PMID:19933576
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P16104	Human	PMID:20000738
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q13573	Human	PMID:20467437
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q71DI3	Human	PMID:20580717
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P63104	Human	PMID:20618440
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q96RG2	Human	PMID:21418524
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q09013	Human	PMID:21949239
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P20700	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:O75531	Human	PMID:22399800
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9UH99	Human	PMID:22555292
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P16104	Human	PMID:23658700
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8WXH0-1	Human	PMID:23977161
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q03252	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9UII6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:O75694	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P20700	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P42166	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P50402	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q03252	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q93009	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P20700	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P20700	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q03252	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:O75694	Human	PMID:30488537
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P50402	Human	PMID:30488537
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9UII6	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q0D2I5	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q0D2I5-5	Human	PMID:31548606
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8TBZ8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q96FA3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9UII6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:A6H8Z2-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:O43309	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:O75886	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:O75925	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:O76041	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P10073	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P10074	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P17024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P20700	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P54274-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P58499	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:P62701	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q03181-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q04323-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q12986	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q13123	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q13133-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q13573	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q14005-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q14585	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q15776	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q3B820	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q3SX64	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q5VYS8-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q6H8Q1-8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q6X4W1-6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q6ZN57	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q6ZNE9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q6ZNH5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q70EL1-9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q7Z3I7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q7Z698	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q86WT6-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8IYM2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8IZU1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8N0Y2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8N488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8NA54	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8NEA9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8TBE0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8TCX5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8WVD3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8WW38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q8WXF7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q96DX5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q96EL1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q96GN5-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q96KP6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q96LX8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q96MN9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q99612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9BS31	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9BZ95-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9C0F3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9HBE1-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9NWB1-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9ULD4-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9UNE7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9Y239	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q9Y4E8-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LMNA	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Lmna	IPI	UniProtKB:Q5FW52	Mouse	MGI:MGI:5700584|PMID:26436652
Molecular Function	GO:0005515	protein binding	Lmna	IPI	PR:O08810	Mouse	PMID:11739632
Molecular Function	GO:0005515	protein binding	Lmna	IPI	PR:Q8BJS4	Mouse	PMID:16380439
Molecular Function	GO:0005515	protein binding	Lmna	IPI	PR:A2A8U2	Mouse	PMID:22349700
Molecular Function	GO:0005515	protein binding	Lmna	IPI	PR:Q62093	Mouse	PMID:11739632
Molecular Function	GO:0005515	protein binding	Lmna	IPI	PR:Q9D666	Mouse	PMID:16380439
Molecular Function	GO:0005515	protein binding	Lmna	IPI	RGD:71058	Rat	PMID:16518874|RGD:10054427
Molecular Function	GO:0008157	protein phosphatase 1 binding	Lmna	IPI	RGD:3377	Rat	PMID:17683050|RGD:2293745
Cellular Component	GO:0005638	lamin filament	Lmna	IDA		Mouse	PMID:8032679
Cellular Component	GO:0005635	nuclear envelope	LMNA	IMP		Human	PMID:21610090
Cellular Component	GO:0005635	nuclear envelope	LMNA	IDA		Human	PMID:18606848
Cellular Component	GO:0005635	nuclear envelope	LMNA	IDA		Human	PMID:27534416
Cellular Component	GO:0005635	nuclear envelope	Lmna	IDA		Mouse	MGI:MGI:4834988|PMID:18606848
Cellular Component	GO:0005635	nuclear envelope	Lmna	IDA		Mouse	PMID:20457914
Cellular Component	GO:0005635	nuclear envelope	Lmna	IDA		Mouse	PMID:23686339
Cellular Component	GO:0005635	nuclear envelope	Lmna	IDA		Rat	PMID:15703219|RGD:152995498
Cellular Component	GO:0016363	nuclear matrix	LMNA	IDA		Human	PMID:31548606
Cellular Component	GO:0016363	nuclear matrix	Lmna	IDA		Rat	PMID:12243746|RGD:1598684
Cellular Component	GO:0031965	nuclear membrane	LMNA	HDA		Human	PMID:16791210
Cellular Component	GO:0031965	nuclear membrane	Lmna	IDA		Mouse	PMID:17164264
Cellular Component	GO:0031965	nuclear membrane	Lmna	IDA		Mouse	PMID:11092755
Cellular Component	GO:0031965	nuclear membrane	Lmna	IDA		Mouse	PMID:32175648
Cellular Component	GO:0016607	nuclear speck	LMNA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	LMNA	IDA		Human	PMID:27534416
Cellular Component	GO:0005634	nucleus	LMNA	HDA		Human	PMID:16791210
Cellular Component	GO:0005634	nucleus	LMNA	IDA		Human	PMID:18809582
Cellular Component	GO:0005634	nucleus	LMNA	IDA		Human	PMID:20810912
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Mouse	MGI:MGI:5700584|PMID:26436652
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Mouse	MGI:MGI:3810856|PMID:18664494
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Mouse	PMID:16731532
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Mouse	PMID:28930673
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Mouse	PMID:26657864
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Mouse	PMID:11739632
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Mouse	PMID:19915186
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Mouse	PMID:22886301
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Rat	PMID:15942958|RGD:1598733
Cellular Component	GO:0005634	nucleus	Lmna	IDA		Rat	PMID:16128803|RGD:1624986
Cellular Component	GO:0035861	site of double-strand break	LMNA	IDA		Human	PMID:31548606
Biological Process	GO:0061337	cardiac conduction	lmna	IMP	ZFIN:ZDB-CRISPR-210722-3,ZFIN:ZDB-CRISPR-210722-4,ZFIN:ZDB-CRISPR-210722-5,ZFIN:ZDB-CRISPR-210722-6	Zfish	PMID:31977013
Biological Process	GO:0061337	cardiac conduction	lmna	IMP	ZFIN:ZDB-GENO-220613-4	Zfish	PMID:31977013
Biological Process	GO:0071456	cellular response to hypoxia	LMNA	IEP		Human	PMID:20810912
Biological Process	GO:0090398	cellular senescence	LMNA	IDA		Human	PMID:20458013
Biological Process	GO:0090398	cellular senescence	Lmna	IEP		Rat	PMID:20362703|RGD:12791030
Biological Process	GO:1990683	DNA double-strand break attachment to nuclear envelope	LMNA	IDA		Human	PMID:31548606
Biological Process	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	Lmna	IMP		Mouse	MGI:MGI:3841905|PMID:17631533
Biological Process	GO:0060047	heart contraction	lmna	IMP		Zfish	PMID:19800866
Biological Process	GO:0060047	heart contraction	lmna	IMP	ZFIN:ZDB-MRPHLNO-100114-5	Zfish	PMID:19800866
Biological Process	GO:1904178	negative regulation of adipose tissue development	Lmna	IMP		Rat	PMID:22119912|RGD:10003161
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	Lmna	IMP		Mouse	MGI:MGI:5700584|PMID:26436652
Biological Process	GO:0008285	negative regulation of cell population proliferation	LMNA	IMP		Human	PMID:27534416
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Lmna	IMP		Mouse	PMID:21151901
Biological Process	GO:0072201	negative regulation of mesenchymal cell proliferation	Lmna	IMP		Mouse	PMID:22886301
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	Lmna	IMP		Mouse	PMID:21151901
Biological Process	GO:0006998	nuclear envelope organization	Lmna	IGI	MGI:MGI:1890508	Mouse	PMID:15608054
Biological Process	GO:0006997	nucleus organization	Lmna	IMP	MGI:MGI:2177930	Mouse	PMID:14755333
Biological Process	GO:0006997	nucleus organization	Lmna	IGI	MGI:MGI:1890508	Mouse	PMID:16511604
Biological Process	GO:0010628	positive regulation of gene expression	Lmna	IMP		Mouse	PMID:22886301
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Lmna	IMP		Rat	PMID:22119912|RGD:10003161
Biological Process	GO:0006606	protein import into nucleus	Lmna	IMP	MGI:MGI:2177930	Mouse	PMID:14755333
Biological Process	GO:0034504	protein localization to nucleus	Lmna	IMP		Mouse	MGI:MGI:5013554|PMID:21498514
Biological Process	GO:0034504	protein localization to nucleus	Lmna	IMP	MGI:MGI:2177930	Mouse	PMID:16339967
Biological Process	GO:0030334	regulation of cell migration	Lmna	IMP		Mouse	MGI:MGI:3841905|PMID:17631533
Biological Process	GO:2000772	regulation of cellular senescence	lmna	IMP	ZFIN:ZDB-MRPHLNO-110517-1	Zfish	PMID:21479207
Biological Process	GO:1900180	regulation of protein localization to nucleus	Lmna	IMP		Mouse	PMID:22349700
Biological Process	GO:0031647	regulation of protein stability	Lmna	IMP		Mouse	PMID:23695662
Biological Process	GO:0009612	response to mechanical stimulus	Lmna	IEP		Rat	PMID:24036726|RGD:10003162
Biological Process	GO:0007519	skeletal muscle tissue development	lmna	IMP	ZFIN:ZDB-GENO-230123-3	Zfish	PMID:34599606
Biological Process	GO:0007283	spermatogenesis	Lmna	IEP		Rat	PMID:8912709|RGD:729065
Biological Process	GO:0055015	ventricular cardiac muscle cell development	Lmna	IMP	MGI:MGI:2177930	Mouse	PMID:14755333

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern