Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LMX1A
  • Mouse genes Lmx1a
  • Rat genes Lmx1a
  • Zfish genes lmx1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lmx1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Lmx1a	IDA		Mouse	MGI:MGI:5705221|PMID:19951692
Molecular Function	GO:0005515	protein binding	LMX1A	IPI	UniProtKB:P62993	Human	PMID:25814554
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Lmx1a	IDA		Mouse	MGI:MGI:5705221|PMID:19951692
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	LMX1A	IDA		Human	PMID:28473536
Biological Process	GO:0007411	axon guidance	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:15183721
Biological Process	GO:0007420	brain development	Lmx1a	IMP		Rat	PMID:15804398|RGD:1549451
Biological Process	GO:0007417	central nervous system development	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:15148302
Biological Process	GO:0021953	central nervous system neuron differentiation	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:15148302
Biological Process	GO:0021953	central nervous system neuron differentiation	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:17670789
Biological Process	GO:0021549	cerebellum development	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:1638738
Biological Process	GO:0021542	dentate gyrus development	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:1638738
Biological Process	GO:0071542	dopaminergic neuron differentiation	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:24066094
Biological Process	GO:0071542	dopaminergic neuron differentiation	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:21752929
Biological Process	GO:0021766	hippocampus development	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:1638738
Biological Process	GO:0007626	locomotory behavior	Lmx1a	IGI	UniProtKB:O88609	Mouse	MGI:MGI:5645828|PMID:25915474
Biological Process	GO:0007613	memory	Lmx1a	IGI	UniProtKB:O88609	Mouse	MGI:MGI:5645828|PMID:25915474
Biological Process	GO:0030901	midbrain development	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:21752929
Biological Process	GO:1904948	midbrain dopaminergic neuron differentiation	Lmx1a	IDA		Mouse	MGI:MGI:5705221|PMID:19951692
Biological Process	GO:0045665	negative regulation of neuron differentiation	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:15148302
Biological Process	GO:0030182	neuron differentiation	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:15183721
Biological Process	GO:0042048	olfactory behavior	Lmx1a	IGI	UniProtKB:O88609	Mouse	MGI:MGI:5645828|PMID:25915474
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lmx1a	IDA		Mouse	MGI:MGI:5705221|PMID:19951692
Biological Process	GO:0001558	regulation of cell growth	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:17670789
Biological Process	GO:0010468	regulation of gene expression	Lmx1a	IMP	MGI:MGI:1888413	Mouse	PMID:17670789
Biological Process	GO:0050808	synapse organization	Lmx1a	IGI	UniProtKB:O88609	Mouse	MGI:MGI:5645828|PMID:25915474

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern