Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LONP1
  • Mouse genes Lonp1
  • Rat genes Lonp1
  • Zfish genes lonp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lonp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	LONP1	IDA		Human	PMID:14739292
Molecular Function	GO:0005524	ATP binding	LONP1	IDA		Human	PMID:14739292
Molecular Function	GO:0016887	ATP hydrolysis activity	LONP1	IMP		Human	PMID:14739292
Molecular Function	GO:0016887	ATP hydrolysis activity	Lonp1	IDA		Mouse	PMID:12657466
Molecular Function	GO:0004176	ATP-dependent peptidase activity	LONP1	IMP		Human	PMID:14739292
Molecular Function	GO:0004176	ATP-dependent peptidase activity	LONP1	IDA		Human	PMID:17420247
Molecular Function	GO:0004176	ATP-dependent peptidase activity	LONP1	IDA		Human	PMID:8248235
Molecular Function	GO:0004176	ATP-dependent peptidase activity	Lonp1	IDA		Mouse	PMID:12657466
Molecular Function	GO:0004176	ATP-dependent peptidase activity	Lonp1	IDA		Rat	PMID:12752449|RGD:1580665
Molecular Function	GO:0070182	DNA polymerase binding	LONP1	IPI	UniProtKB:P54098	Human	PMID:14739292
Molecular Function	GO:0051880	G-quadruplex DNA binding	LONP1	IDA		Human	PMID:18174225
Molecular Function	GO:0042802	identical protein binding	LONP1	IPI	UniProtKB:P36776	Human	PMID:14739292
Molecular Function	GO:0043560	insulin receptor substrate binding	Lonp1	IPI	PR:P81122	Mouse	PMID:9813005
Molecular Function	GO:0001018	mitochondrial promoter sequence-specific DNA binding	LONP1	IDA		Human	PMID:9485316
Molecular Function	GO:0001018	mitochondrial promoter sequence-specific DNA binding	Lonp1	IDA		Mouse	PMID:12657466
Molecular Function	GO:0042731	PH domain binding	Lonp1	IPI	PR:P81122	Mouse	PMID:9813005
Molecular Function	GO:0005515	protein binding	LONP1	IPI	UniProtKB:Q96RR1	Human	PMID:14739292
Molecular Function	GO:0005515	protein binding	LONP1	IPI	UniProtKB:P02666	Human	PMID:24520911
Molecular Function	GO:0043565	sequence-specific DNA binding	LONP1	IDA		Human	PMID:14739292
Molecular Function	GO:0003697	single-stranded DNA binding	Lonp1	IDA		Mouse	PMID:12657466
Molecular Function	GO:0003727	single-stranded RNA binding	LONP1	IDA		Human	PMID:14739292
Cellular Component	GO:0005829	cytosol	LONP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	LONP1	HDA		Human	PMID:19946888
Cellular Component	GO:0005759	mitochondrial matrix	LONP1	IMP		Human	PMID:12198491
Cellular Component	GO:0005759	mitochondrial matrix	Lonp1	IDA		Rat	PMID:15560797|RGD:2303495
Cellular Component	GO:0042645	mitochondrial nucleoid	LONP1	IDA		Human	PMID:18063578
Cellular Component	GO:0005739	mitochondrion	LONP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	LONP1	IDA		Human	PMID:8248235
Cellular Component	GO:0005739	mitochondrion	Lonp1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Lonp1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Lonp1	IDA		Mouse	PMID:12657466
Cellular Component	GO:0005739	mitochondrion	Lonp1	IDA		Rat	PMID:12752449|RGD:1580665
Cellular Component	GO:0005654	nucleoplasm	LONP1	IDA		Human	GO_REF:0000052
Biological Process	GO:0007568	aging	Lonp1	IEP		Rat	PMID:15560797|RGD:2303495
Biological Process	GO:0034599	cellular response to oxidative stress	LONP1	IDA		Human	PMID:17420247
Biological Process	GO:0007005	mitochondrion organization	LONP1	IMP		Human	PMID:15683722
Biological Process	GO:0007005	mitochondrion organization	Lonp1	IEP		Rat	PMID:10050756|RGD:1580666
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Lonp1	IDA		Mouse	PMID:9813005
Biological Process	GO:0070407	oxidation-dependent protein catabolic process	LONP1	IMP		Human	PMID:12198491
Biological Process	GO:0030163	protein catabolic process	Lonp1	IDA		Rat	PMID:12752449|RGD:1580665
Biological Process	GO:0065003	protein-containing complex assembly	Lonp1	IMP		Rat	PMID:12082077|RGD:633879
Biological Process	GO:0006508	proteolysis	Lonp1	IDA		Mouse	PMID:12657466
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	LONP1	IDA		Human	PMID:17420247
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	LONP1	IDA		Human	PMID:8248235
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Lonp1	IDA		Mouse	PMID:9813005
Biological Process	GO:0010044	response to aluminum ion	Lonp1	IEP		Rat	PMID:19010380|RGD:2303407
Biological Process	GO:0009725	response to hormone	Lonp1	IEP		Rat	PMID:10050756|RGD:1580666
Biological Process	GO:0001666	response to hypoxia	LONP1	IEP		Human	PMID:17418790
Biological Process	GO:0001666	response to hypoxia	Lonp1	IEP		Rat	PMID:12082077|RGD:633879

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern